P19_TBSVT
ID P19_TBSVT Reviewed; 172 AA.
AC P50628;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 56.
DE RecName: Full=RNA silencing suppressor p19;
DE AltName: Full=19 kDa symptom severity modulator;
GN ORFNames=ORF4;
OS Tomato bushy stunt virus (strain type) (TBSV).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Tolucaviricetes;
OC Tolivirales; Tombusviridae; Procedovirinae; Tombusvirus.
OX NCBI_TaxID=70159;
OH NCBI_TaxID=4072; Capsicum annuum (Capsicum pepper).
OH NCBI_TaxID=3749; Malus.
OH NCBI_TaxID=3766; Pyrus (pears).
OH NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH NCBI_TaxID=4111; Solanum melongena (Eggplant) (Aubergine).
OH NCBI_TaxID=29777; Tolmiea menziesii.
OH NCBI_TaxID=13305; Tulipa.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX AGRICOLA=IND20581771;
RA Luis-Areteaga M., Rodriguez-Cerezo E., Fraile A., Saez E.,
RA Garcia-Arenal F.;
RT "Different tomato bushy stunt virus strains cause disease outbreaks on
RT solanaceous crops in Spain.";
RL Phytopathology 86:535-542(1996).
CC -!- FUNCTION: Viral suppressor of RNA silencing which binds specifically to
CC silencing RNAs (siRNAs). Acts as a molecular caliper to specifically
CC select siRNAs based on the length of the duplex region of the RNA (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the tombusvirus protein p19 family.
CC {ECO:0000305}.
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DR EMBL; Z68899; CAA93132.1; -; Genomic_RNA.
DR SMR; P50628; -.
DR GO; GO:0044423; C:virion component; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.390.180; -; 1.
DR InterPro; IPR004905; Tombusvirus_p19.
DR InterPro; IPR036131; VP19_sf.
DR Pfam; PF03220; Tombus_P19; 1.
DR SUPFAM; SSF103145; SSF103145; 1.
PE 3: Inferred from homology;
KW RNA-binding; Suppressor of RNA silencing.
FT CHAIN 1..172
FT /note="RNA silencing suppressor p19"
FT /id="PRO_0000222884"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 172 AA; 19421 MW; E51E7FB9BA7FAA29 CRC64;
MERAIQGNDA REQANSERWD GGSGSSTSPF QLPDESPSWT EWRLHNDETN SNQDNPLGFK
ESWGFGKVVF KRYLRYERTE TSLHRVLGSW TGDSVNYAAS RFFGVNQIGC TYSIRFRGVS
VTISGGSRTL QHLCEMAIRS KQELLQLTPV EVESNVSRGC PEGVETFEEE SE