ID   ASF1_CAEEL              Reviewed;         275 AA.
AC   Q19326;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Probable histone chaperone asf-1;
DE   AltName: Full=Anti-silencing function protein 1;
GN   Name=unc-85 {ECO:0000312|WormBase:F10G7.3};
GN   Synonyms=asf-1 {ECO:0000312|WormBase:F10G7.3};
GN   ORFNames=F10G7.3 {ECO:0000312|WormBase:F10G7.3};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Histone chaperone that facilitates histone deposition and
CC       histone exchange and removal during nucleosome assembly and
CC       disassembly. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histone H3 and histone H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ASF1 family. {ECO:0000305}.
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DR   EMBL; FO081114; CCD69205.1; -; Genomic_DNA.
DR   PIR; H88130; H88130.
DR   RefSeq; NP_494837.2; NM_062436.4.
DR   AlphaFoldDB; Q19326; -.
DR   SMR; Q19326; -.
DR   BioGRID; 39163; 10.
DR   IntAct; Q19326; 1.
DR   STRING; 6239.F10G7.3; -.
DR   iPTMnet; Q19326; -.
DR   EPD; Q19326; -.
DR   PaxDb; Q19326; -.
DR   PeptideAtlas; Q19326; -.
DR   EnsemblMetazoa; F10G7.3.1; F10G7.3.1; WBGene00006817.
DR   GeneID; 173809; -.
DR   KEGG; cel:CELE_F10G7.3; -.
DR   UCSC; F10G7.3; c. elegans.
DR   CTD; 173809; -.
DR   WormBase; F10G7.3; CE39722; WBGene00006817; unc-85.
DR   eggNOG; KOG3265; Eukaryota.
DR   GeneTree; ENSGT00390000004692; -.
DR   HOGENOM; CLU_060354_0_2_1; -.
DR   InParanoid; Q19326; -.
DR   OMA; SYDEREF; -.
DR   OrthoDB; 1295345at2759; -.
DR   PhylomeDB; Q19326; -.
DR   PRO; PR:Q19326; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00006817; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0016573; P:histone acetylation; IEA:InterPro.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0006337; P:nucleosome disassembly; IEA:InterPro.
DR   GO; GO:0018991; P:oviposition; IMP:WormBase.
DR   GO; GO:0009791; P:post-embryonic development; IMP:WormBase.
DR   Gene3D; 2.60.40.1490; -; 1.
DR   InterPro; IPR006818; ASF1-like.
DR   InterPro; IPR036747; ASF1-like_sf.
DR   InterPro; IPR017282; Hist_deposition_Asf1.
DR   PANTHER; PTHR12040; PTHR12040; 1.
DR   Pfam; PF04729; ASF1_hist_chap; 1.
DR   PIRSF; PIRSF037759; Histone_Asf1; 1.
DR   SUPFAM; SSF101546; SSF101546; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..275
FT                   /note="Probable histone chaperone asf-1"
FT                   /id="PRO_0000284023"
FT   REGION          157..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..206
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..275
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   275 AA;  31240 MW;  3D468D108F723038 CRC64;
     MASRVNIVQV QILDNPAMFV DKFKLEITFE VFEHLPHDLE WELVYVGSGT SRDFDQVLDS
     ALVGPIPEGR HKFVFDADHP DISKIPVDDI VGVSVLLLRC KYNDQEFINM GWFVANEYTE
     EELKENPPSQ PLIEKLSRKV ETEDLRITTF PIRWTDEDPV AEPVEDEANR VFAEDDLMPL
     NDDGQEDDDE EEEDDDEMEA NAEEVDLNES FNERLANALD GAEQKGADEK MEDDGANEDV
     DMADDEPGVQ INTDTKVPES MAEPLSDKTN NEMVQ