P200_MYCGE
ID P200_MYCGE Reviewed; 1616 AA.
AC Q49429; Q49259; Q49298; Q49352; Q49353;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Protein P200;
GN OrderedLocusNames=MG386;
OS Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS (Mycoplasmoides genitalium).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=243273;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 256-427; 432-543 AND 1083-1140.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A survey of the Mycoplasma genitalium genome by using random sequencing.";
RL J. Bacteriol. 175:7918-7930(1993).
CC -!- FUNCTION: Could be an accessory structural component in cytadherence.
CC {ECO:0000250}.
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DR EMBL; L43967; AAC71613.1; -; Genomic_DNA.
DR EMBL; U02245; AAA03400.1; -; Genomic_DNA.
DR EMBL; U02175; AAD12458.1; -; Genomic_DNA.
DR EMBL; U02126; AAD12402.1; -; Genomic_DNA.
DR PIR; G64242; G64242.
DR RefSeq; WP_010869461.1; NC_000908.2.
DR AlphaFoldDB; Q49429; -.
DR SMR; Q49429; -.
DR STRING; 243273.MG_386; -.
DR EnsemblBacteria; AAC71613; AAC71613; MG_386.
DR KEGG; mge:MG_386; -.
DR eggNOG; COG3115; Bacteria.
DR HOGENOM; CLU_243703_0_0_14; -.
DR OMA; HSAYNDT; -.
DR OrthoDB; 2028499at2; -.
DR BioCyc; MGEN243273:G1GJ2-482-MON; -.
DR Proteomes; UP000000807; Chromosome.
DR GO; GO:0020035; P:adhesion of symbiont to microvasculature; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.3600; -; 5.
DR InterPro; IPR022466; EAGR_box.
DR InterPro; IPR038145; EAGR_sf.
DR Pfam; PF16713; EAGR_box; 5.
DR TIGRFAMs; TIGR03834; EAGR_box; 4.
PE 3: Inferred from homology;
KW Cytadherence; Reference proteome; Repeat.
FT CHAIN 1..1616
FT /note="Protein P200"
FT /id="PRO_0000058127"
FT REPEAT 1161..1186
FT /note="2-1"
FT REPEAT 1205..1236
FT /note="1-1"
FT REPEAT 1310..1339
FT /note="2-2"
FT REPEAT 1358..1389
FT /note="1-2"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..1389
FT /note="2 X 26 AA repeats"
FT REGION 931..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1100..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1159..1433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1205..1389
FT /note="2 X 32 AA repeats"
FT COMPBIAS 16..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..970
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1030
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1060
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1067..1082
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1185..1231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1259..1273
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1405..1419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 256
FT /note="P -> S (in Ref. 2; AAA03400)"
FT /evidence="ECO:0000305"
FT CONFLICT 304
FT /note="S -> F (in Ref. 2; AAA03400)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1616 AA; 185679 MW; 6AF76A13AC49E4FF CRC64;
MPKTTKNKNK NTTPKSKTKK YLESANKKSV TKPKKEQDKV ENLFDQPFLG EIKKNILKKT
KSFNSKKKET VKSKSKSPID FFDETKRGVF IVPPETDILS RRELNQKTVV NTVPNQTSSY
PTINENKLVE LNNQPETKVL ETKKDSFTTT IREKKLNPED SQAFWYIFVG DRKYGFWKNH
TWVWLGYFDQ LQRWNYFKVI ETVEVPQEHA AFIKQRPADI DFWRPLVGNP NYGFVQNNTW
IWKGFFDKKL NWIPDPVRFT EEALGHTDSL VDEIEKKTIS EQPYWEQEND IVVTVFNTKS
LASSLENELL LENSSEEQPV IEEVKPRRNE VIFRNPVTKL HFEKEKFEFL NPVKETNETI
PLIEIVKEEV KVESEVEAPV EIEPEAACEP ETTIPEVETV FVYEDDLKGL DSNQTQAGNV
PEVETVFVYE DDLKGLDSII KDDQQHDEIA KHVEHLSQDY SKEIKDSAKA DLSNISDDID
SVWKEFGSFT DETQKSVEEK SQVDEIILDA NNDFINESLF RDEVVNNIDS QINETVSEQQ
FEPTYSVNEF QQEFSEPVVS DEKIKETNSD ESVNTDLTAL FSEKLVNEVL LTNEYVDVNA
PFSTETEVKV SSELPKSELV DEITFINNDP KPQEGLEYKV DFLETEPKSL FDEKTTIVVE
SEPPFIQPDL SLELDSVNDV DKSLETKTTS VELNHEEIGN EFINLDVSEK EVQEQPTTQL
ETDSEFVLPT YQIVEDSFTE SAETPNEFSS EQKDTLEFIS QTQEVETSES NVPTVEQETK
LFEHQDENNL FTPLPLDLTE IIESNALFDS KPDEKESSDS ELQPTFKEIK LDSTVEVPQE
SSQVEATFDT VQPEAVFDEI KTQELQPEAT TEVVFDDHFQ PDVQPEQTPQ EAKFDSPVEI
PQESSQAEFH AEQISDEIKL EEKTEAVFDH QQLENQSEET VVTPTEVTAF EPETIETQLE
PSSEDQPSEP ALDQNHPEIV TAEVEQIFDG TKLEDLKLEE ANFDNVENNE VQPKETEAEI
TFDETKELQQ ETSSEPLSTE ELKSEATFDN VSEAESEAVF EKPQLETQTE KILEEEPKSE
PVDQLITEAS FDTVKHEAVF DKNQTQTEGL EEPQVSSEAE VVDQTTTDTV GEPEAVFDVQ
PEKTTEVKFD DVENQQKVIS EPQVEQQPGE AVFEPSAEAK FDSPVESVQD SQPEPVLEEV
QTQPEIQPVE SQPEATFDTV QPEQTPQEAK FDSPVETVEQ PEFSSEPTQQ HVESEASFDE
PNYDFDEPNY DFDQPSYDSD LQPSEPQYDV DEPNYDFDEP NYEIESKPSE PQFEPQVEQQ
PGEAVFEPSA EAKFDSPVES VQDSQPEPLL EEVQTQPEIQ PVESQPEATF DTVQPEQTPQ
EAKFDSPVET IQEPQVSSEP EVVVQPNFEE RKPETVLEEP QADEIQPEAS EEESLDWELL
VGNNSYGHYE PDGEWVWAGF FGDDQKWNKD ATVKWARERD YLPLIGDEVY GRYNNKGEWI
WYGFYDESGD WVLVDEQWKN RQPRINEAPK FWEKLIGNEE YGYYEDNEWN WYDGEFDSEG
NWLVFQSEET ENLNEDITKD IPALEGYDID SIDADEWLSQ FSADDAKDVF GSNDKK
