ASF1_CANAL
ID ASF1_CANAL Reviewed; 247 AA.
AC Q59MV1; A0A1D8PTM2;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Histone chaperone ASF1;
DE AltName: Full=Anti-silencing function protein 1;
GN Name=ASF1; OrderedLocusNames=CAALFM_CR07860CA;
GN ORFNames=CaO19.11200, CaO19.3715;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Histone chaperone that facilitates histone deposition and
CC histone exchange and removal during nucleosome assembly and
CC disassembly. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with histone H3 and histone H4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ASF1 family. {ECO:0000305}.
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DR EMBL; CP017630; AOW31477.1; -; Genomic_DNA.
DR RefSeq; XP_711054.1; XM_705962.1.
DR AlphaFoldDB; Q59MV1; -.
DR SMR; Q59MV1; -.
DR STRING; 237561.Q59MV1; -.
DR GeneID; 3647348; -.
DR KEGG; cal:CAALFM_CR07860CA; -.
DR CGD; CAL0000179732; ASF1.
DR VEuPathDB; FungiDB:CR_07860C_A; -.
DR eggNOG; KOG3265; Eukaryota.
DR HOGENOM; CLU_060354_0_1_1; -.
DR InParanoid; Q59MV1; -.
DR OMA; KINWDYG; -.
DR OrthoDB; 1334998at2759; -.
DR PRO; PR:Q59MV1; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0070775; C:H3 histone acetyltransferase complex; IEA:EnsemblFungi.
DR GO; GO:0010698; F:acetyltransferase activator activity; IEA:EnsemblFungi.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IBA:GO_Central.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR GO; GO:0043486; P:histone exchange; IEA:EnsemblFungi.
DR GO; GO:0033523; P:histone H2B ubiquitination; IEA:EnsemblFungi.
DR GO; GO:0097043; P:histone H3-K56 acetylation; IEA:EnsemblFungi.
DR GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR GO; GO:0006337; P:nucleosome disassembly; IEA:EnsemblFungi.
DR GO; GO:0035066; P:positive regulation of histone acetylation; IEA:EnsemblFungi.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:EnsemblFungi.
DR GO; GO:0043618; P:regulation of transcription from RNA polymerase II promoter in response to stress; IEA:EnsemblFungi.
DR GO; GO:0030466; P:silent mating-type cassette heterochromatin assembly; IEA:EnsemblFungi.
DR GO; GO:0031509; P:subtelomeric heterochromatin assembly; IEA:EnsemblFungi.
DR Gene3D; 2.60.40.1490; -; 1.
DR InterPro; IPR006818; ASF1-like.
DR InterPro; IPR036747; ASF1-like_sf.
DR InterPro; IPR017282; Hist_deposition_Asf1.
DR PANTHER; PTHR12040; PTHR12040; 1.
DR Pfam; PF04729; ASF1_hist_chap; 1.
DR PIRSF; PIRSF037759; Histone_Asf1; 1.
DR SUPFAM; SSF101546; SSF101546; 1.
PE 3: Inferred from homology;
KW Chaperone; Chromatin regulator; Coiled coil; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..247
FT /note="Histone chaperone ASF1"
FT /id="PRO_0000284029"
FT REGION 151..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 165..193
FT /evidence="ECO:0000255"
FT COMPBIAS 158..203
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..235
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 247 AA; 27993 MW; DAD954B87F39E0BC CRC64;
MSIVSLTGIE VLNNPAKFTD PYEFQITFEC LEPLKEDLEW KLTYVGSSDS LDHDQELDSI
LVGPVPVGIN SFLFKADAPS PELIPASELV SVTVIILSCS YNDKEFVRVG YYVNNEYDTE
ELRENPPAKV AIDHVVRNIL AEKPRVTRFN IVWDNEEGAD EYPPEQPEDE EEEEEEEEEG
EEEEEDEDEE DDDDDEDLNG DAVVDLEKEE ISTPRDNDED IEIDIASESE VEEGGVEEEA
KVNTPKD
