P200_MYCPN
ID P200_MYCPN Reviewed; 1036 AA.
AC P75211; Q50346;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Protein P200;
GN Name=p200; OrderedLocusNames=MPN_567; ORFNames=MP275;
OS Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS pneumoniae).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=272634;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 29342 / M129;
RX PubMed=8675035; DOI=10.1016/0378-1119(96)00014-5;
RA Proft T., Hilbert H., Plagens H., Herrmann R.;
RT "The P200 protein of Mycoplasma pneumoniae shows common features with the
RT cytadherence-associated proteins HMW1 and HMW3.";
RL Gene 171:79-82(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29342 / M129;
RX PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT pneumoniae.";
RL Nucleic Acids Res. 24:4420-4449(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 641-678.
RC STRAIN=ATCC 29342 / M129;
RX PubMed=7984111; DOI=10.1111/j.1365-2958.1994.tb00427.x;
RA Proft T., Herrmann R.;
RT "Identification and characterization of hitherto unknown Mycoplasma
RT pneumoniae proteins.";
RL Mol. Microbiol. 13:337-348(1994).
RN [4]
RP FUNCTION IN GLIDING MOTILITY, SUBCELLULAR LOCATION, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=ATCC 29342 / M129-B18;
RX PubMed=17043103; DOI=10.1128/iai.01344-06;
RA Jordan J.L., Chang H.Y., Balish M.F., Holt L.S., Bose S.R.,
RA Hasselbring B.M., Waldo R.H. III, Krunkosky T.M., Krause D.C.;
RT "Protein P200 is dispensable for Mycoplasma pneumoniae hemadsorption but
RT not gliding motility or colonization of differentiated bronchial
RT epithelium.";
RL Infect. Immun. 75:518-522(2007).
CC -!- FUNCTION: Protein cytoskeleton-associated which plays a role in gliding
CC motility and perhaps also in mucociliary clearance.
CC {ECO:0000269|PubMed:17043103}.
CC -!- SUBCELLULAR LOCATION: Cell projection, attachment organelle
CC {ECO:0000269|PubMed:17043103}.
CC -!- DISRUPTION PHENOTYPE: Has impaired gliding motility, glides at a slower
CC speed and with longer resting periods than wild-type. Binds equally
CC well to erythrocytes and a human lung adenocarcinoma cell line, but
CC colonizes mucin-producing cells less well than wild-type cells.
CC {ECO:0000269|PubMed:17043103}.
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DR EMBL; U25989; AAC99815.1; -; Genomic_DNA.
DR EMBL; U00089; AAB95923.1; -; Genomic_DNA.
DR EMBL; Z32646; CAA83569.1; -; Genomic_DNA.
DR PIR; S73601; S73601.
DR RefSeq; NP_110256.1; NC_000912.1.
DR RefSeq; WP_010874924.1; NC_000912.1.
DR AlphaFoldDB; P75211; -.
DR SMR; P75211; -.
DR IntAct; P75211; 3.
DR STRING; 272634.MPN_567; -.
DR EnsemblBacteria; AAB95923; AAB95923; MPN_567.
DR KEGG; mpn:MPN_567; -.
DR PATRIC; fig|272634.6.peg.629; -.
DR HOGENOM; CLU_293347_0_0_14; -.
DR OMA; WARESDY; -.
DR BioCyc; MPNE272634:G1GJ3-929-MON; -.
DR Proteomes; UP000000808; Chromosome.
DR GO; GO:0033099; C:attachment organelle; IEA:UniProtKB-SubCell.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.3600; -; 5.
DR InterPro; IPR022466; EAGR_box.
DR InterPro; IPR038145; EAGR_sf.
DR Pfam; PF16713; EAGR_box; 6.
DR TIGRFAMs; TIGR03834; EAGR_box; 5.
PE 1: Evidence at protein level;
KW Cell projection; Reference proteome; Repeat.
FT CHAIN 1..1036
FT /note="Protein P200"
FT /id="PRO_0000058128"
FT REPEAT 718..723
FT /note="1"
FT REPEAT 738..743
FT /note="2"
FT REPEAT 776..781
FT /note="3"
FT REGION 697..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..781
FT /note="3 X 6 AA repeats of E-P-E-P-N-F"
FT REGION 757..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 641
FT /note="A -> P (in Ref. 3; CAA83569)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1036 AA; 116915 MW; DE5AEBAB6DD95B29 CRC64;
MPKTIKKQNP SNTTLQYKKY LEQSKEKTAK AKNKDVSIDD LLKKPFLEEI KTNVLKKNKT
TRASTATRGT SKVKKQIVES SIDFFDEKKR GVFIVPPAGT SVINDDRDDN KAVEETVSKT
AISQNQLAHY ANSELVETEQ FELKPVALEH NQVLTSTRHS QERESIFEKA QLFWQIFVGD
VRFGFWKNHT WIWLGFFDQH QNWYYFEVVE TVELPQEHTA FIKRKQIDSC FWKPLVGNPN
YGYIQNNIWV WKGFFDTKLN WIPDPVRFTL PMVEKATTTT PVVQIELPAP PTVTVVDQTS
PPTAAVTVST SQPVIEEQTT VFNQTTQLEQ LSVSAPLLDQ SEVETEMVEV PFVAPSTTTT
QPQVVTVQAQ PASSSIQFQE PIIKVEFVNE SFDFKKPSQT AAAASQAPSQ AINIALNEAD
LIDELVAVGT TATTALPQSE LIQEVVVIDN GQPQQAGFHY VVDFLTSTAP LTVAEIELQE
QELVNEFVTT TSRETTTFAS TPVFEPVVIP TVESEEQLLE NEFVESTVVS ATSNEPNVAS
TPVVETVELT ETPVSLEPLE TVQLETAPVV TETVTVTEKA VEPEVLAVVE EAPLAVEPIV
ETSTTLAAET VEEAQVEQES TAVAVEPAIE TESKATSEAQ AELDWEALIG NSEYGYFDAE
QNWIWTGYFD EDNKWVSTAT AQTEANAEEV VLTADAETSE LNTESDPSFE PEVEIQPEPE
PNFDLETIPE PESIETTEPE PNFEPEVELE PEIEPNFESE TEVQQELAQE SSFESEPEPN
FETEVEVQPE SEIESKFEAE VQSEPKVSLN SDFETKPEAQ AEVTPETLEV EATSEAPELQ
PETEATKVVD DVEEEQLDWE LLIGNSNYGH YEPSGEWVWA GYFDDNQIWT PDASVEWARE
SDYTDLIGDE IYGRYNRKGE WIWYGYYDET GEWVLVDEHY QNHQPRISEA PRFWEQLIGN
EDYGYYEDNE WKWYDGEFDS EGNWLVFHSS NAEDAKNIDI AKDIPVFESF DVDSIDADEW
LDQFSDSDAK EVFGED