ID   P20D1_ASPTN             Reviewed;         433 AA.
AC   Q0CTS9;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Probable carboxypeptidase ATEG_02905;
DE            EC=3.4.17.-;
DE   AltName: Full=Peptidase M20 domain-containing protein ATEG_02905;
DE   Flags: Precursor;
GN   ORFNames=ATEG_02905;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase M20A family. {ECO:0000305}.
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DR   EMBL; CH476597; EAU36179.1; -; Genomic_DNA.
DR   RefSeq; XP_001212083.1; XM_001212083.1.
DR   AlphaFoldDB; Q0CTS9; -.
DR   SMR; Q0CTS9; -.
DR   STRING; 341663.Q0CTS9; -.
DR   EnsemblFungi; EAU36179; EAU36179; ATEG_02905.
DR   GeneID; 4317488; -.
DR   VEuPathDB; FungiDB:ATEG_02905; -.
DR   eggNOG; KOG2275; Eukaryota.
DR   HOGENOM; CLU_021802_3_0_1; -.
DR   OMA; VSGHKGM; -.
DR   OrthoDB; 1432382at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR001261; ArgE/DapE_CS.
DR   InterPro; IPR036264; Bact_exopeptidase_dim_dom.
DR   InterPro; IPR002933; Peptidase_M20.
DR   InterPro; IPR011650; Peptidase_M20_dimer.
DR   Pfam; PF07687; M20_dimer; 1.
DR   Pfam; PF01546; Peptidase_M20; 1.
DR   SUPFAM; SSF55031; SSF55031; 1.
DR   PROSITE; PS00758; ARGE_DAPE_CPG2_1; 1.
DR   PROSITE; PS00759; ARGE_DAPE_CPG2_2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Hydrolase; Metal-binding; Protease; Reference proteome;
KW   Secreted; Signal; Zinc.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..433
FT                   /note="Probable carboxypeptidase ATEG_02905"
FT                   /id="PRO_0000411232"
FT   REGION          20..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        193
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         161
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         161
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         194
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        92
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   433 AA;  45628 MW;  79468AC9DCE3B502 CRC64;
     MKSAISLLLA SAATYVGASP HPEPPQLVLS PSTSTGVHGD EATSAIASSA ADDVISDSPF
     LSFHRDLVQI SSISGHERKA GDFVAEFLQA HNFTVVKQPV PSKDGRQPDE DRFNVFAYPS
     GASAAPKILL TSHIDTVPPF IPYSAARVDN DIRISGRGSV DAKGSVAAQV FAALDILERD
     PSAPLGLLFV VDEEVGGTGM KVFSDSSLNP SPSPFRAVIF GEPTDLALVS GHKGMLGFEL
     VATGQAAHSG YPWLGHSAVS ALLPALLRVD RLGDIPAQEG GLPSSPKYGR TTVNIGRMEG
     GVAANVVPAS AHANVAVRLA AGTPDEARDI VRRAVRDATG GDENVYPDFS EWSEGYPPQD
     LDTDVDGFEV TTVNYGTDVP NLRIHERADG APVRRYLYGP GSIHVAHGDH EAITVAQLEE
     ALQGYRKLIE AAM