ID   P20D1_PARBA             Reviewed;         442 AA.
AC   C1GQH3;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Probable carboxypeptidase PAAG_00768;
DE            EC=3.4.17.-;
DE   AltName: Full=Peptidase M20 domain-containing protein PAAG_00768;
DE   Flags: Precursor;
GN   ORFNames=PAAG_00768;
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01;
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase M20A family. {ECO:0000305}.
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DR   EMBL; KN293993; EEH37847.1; -; Genomic_DNA.
DR   RefSeq; XP_002796909.1; XM_002796863.2.
DR   AlphaFoldDB; C1GQH3; -.
DR   SMR; C1GQH3; -.
DR   STRING; 502779.C1GQH3; -.
DR   EnsemblFungi; EEH37847; EEH37847; PAAG_00768.
DR   GeneID; 9100343; -.
DR   KEGG; pbl:PAAG_00768; -.
DR   VEuPathDB; FungiDB:PAAG_00768; -.
DR   eggNOG; KOG2275; Eukaryota.
DR   HOGENOM; CLU_021802_3_0_1; -.
DR   OMA; VSGHKGM; -.
DR   OrthoDB; 1432382at2759; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR036264; Bact_exopeptidase_dim_dom.
DR   InterPro; IPR002933; Peptidase_M20.
DR   InterPro; IPR011650; Peptidase_M20_dimer.
DR   Pfam; PF07687; M20_dimer; 1.
DR   Pfam; PF01546; Peptidase_M20; 1.
DR   SUPFAM; SSF55031; SSF55031; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Hydrolase; Metal-binding; Protease; Reference proteome;
KW   Secreted; Signal; Zinc.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..442
FT                   /note="Probable carboxypeptidase PAAG_00768"
FT                   /id="PRO_0000411237"
FT   ACT_SITE        192
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         160
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         160
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         193
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        343
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   442 AA;  48000 MW;  9AB596C3920C078B CRC64;
     MKLQYLVALL FVQAVPPVTA GYIHQYALAG SAIRQPIDQK TQREDLNKLV SDSPLLSLHR
     TICEIESVSN HEGAVGEMLI KYLRDHDFTV EKQIVPADRG TNSTAERFNI WAYPKGFPRP
     KIILTSHIDT VPPHIKYSLH APDGDFDRAK VRIMGRGTVD AKASVAAQII AALKHLKSNK
     DIPLGLLFVV SEEVGGSGMV HFSNSELNTN PPFFHTLIFG EPTDLTLVDG HKGNLRVTIH
     AKGVAAHSGY PWLGHSAISE ILPILARMDE LGDIPVETGG LPSSEKYGRT TVNIGTIKGG
     AADNVVPETA SASISVRLAA GTPEEAEEVI RRAVNDVSGG STNITVNFPD SMPYPPIDLD
     VDVEGFDIST VNYGTDIPKL EIHDEELEVK VKRYLYGPGT IFVAHGAEEG ITVGDLEKAV
     EGYSKLIDAA VERDWPREVV VN