ID   ASF1_CHICK              Reviewed;         204 AA.
AC   Q3C1E9;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Histone chaperone ASF1;
DE   AltName: Full=Anti-silencing function protein 1 homolog;
GN   Name=ASF1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CHAF1B; HIRA;
RP   HISTONE H3 AND HISTONE H4, SUBCELLULAR LOCATION, PHOSPHORYLATION, AND
RP   MUTAGENESIS OF 36-GLU-ASP-37.
RX   PubMed=16537536; DOI=10.1074/jbc.m511590200;
RA   Sanematsu F., Takami Y., Barman H.K., Fukagawa T., Ono T., Shibahara K.,
RA   Nakayama T.;
RT   "Asf1 is required for viability and chromatin assembly during DNA
RT   replication in vertebrate cells.";
RL   J. Biol. Chem. 281:13817-13827(2006).
CC   -!- FUNCTION: Histone chaperone that facilitates histone deposition and
CC       histone exchange and removal during nucleosome assembly and
CC       disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to
CC       promote replication-dependent chromatin assembly. May also cooperate
CC       with HIRA to promote replication-independent chromatin assembly.
CC       {ECO:0000269|PubMed:16537536}.
CC   -!- SUBUNIT: Interacts with CHAF1B, HIRA, histone H3 and histone H4.
CC       {ECO:0000269|PubMed:16537536}.
CC   -!- INTERACTION:
CC       Q3C1E9; Q5R1S9: CHAF1B; NbExp=2; IntAct=EBI-996834, EBI-996875;
CC       Q3C1E9; P79987: HIRA; NbExp=2; IntAct=EBI-996834, EBI-996848;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16537536}.
CC   -!- PTM: Phosphorylated. {ECO:0000269|PubMed:16537536}.
CC   -!- SIMILARITY: Belongs to the ASF1 family. {ECO:0000305}.
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DR   EMBL; AB238225; BAE46789.1; -; mRNA.
DR   RefSeq; NP_001038155.1; NM_001044690.1.
DR   AlphaFoldDB; Q3C1E9; -.
DR   BMRB; Q3C1E9; -.
DR   SMR; Q3C1E9; -.
DR   BioGRID; 689056; 4.
DR   IntAct; Q3C1E9; 4.
DR   STRING; 9031.ENSGALP00000036573; -.
DR   PaxDb; Q3C1E9; -.
DR   Ensembl; ENSGALT00000073491; ENSGALP00000057957; ENSGALG00000014887.
DR   GeneID; 723780; -.
DR   KEGG; gga:723780; -.
DR   CTD; 25842; -.
DR   VEuPathDB; HostDB:geneid_723780; -.
DR   eggNOG; KOG3265; Eukaryota.
DR   GeneTree; ENSGT00390000004692; -.
DR   InParanoid; Q3C1E9; -.
DR   OMA; KINWDYG; -.
DR   OrthoDB; 1334998at2759; -.
DR   PhylomeDB; Q3C1E9; -.
DR   PRO; PR:Q3C1E9; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000014887; Expressed in spermatid and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   Gene3D; 2.60.40.1490; -; 1.
DR   InterPro; IPR006818; ASF1-like.
DR   InterPro; IPR036747; ASF1-like_sf.
DR   PANTHER; PTHR12040; PTHR12040; 1.
DR   Pfam; PF04729; ASF1_hist_chap; 1.
DR   SUPFAM; SSF101546; SSF101546; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Chromatin regulator; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..204
FT                   /note="Histone chaperone ASF1"
FT                   /id="PRO_0000284017"
FT   REGION          1..155
FT                   /note="Interaction with CHAF1B, HIRA, histone H3 and
FT                   histone H4"
FT                   /evidence="ECO:0000269|PubMed:16537536"
FT   MUTAGEN         36..37
FT                   /note="ED->AA: Abrogates interaction with CHAF1B and HIRA."
FT                   /evidence="ECO:0000269|PubMed:16537536"
SQ   SEQUENCE   204 AA;  22969 MW;  9819D531D3A9FC68 CRC64;
     MAKVQVNNVV VLDNPSPFYN PFQFEITFEC IEDLSEDLEW KIIYVGSAES EEYDQVLDSV
     LVGPVPAGRH MFVFQADAPN PGLIPDADAV GVTVVLITCT YRGQEFIRVG YYVNNEYTET
     ELRENPPVKP DFSKLQRNIL ASNPRVTRFH INWEDNTEKL EDAESSNPNL QSLLSTDALP
     SASKGWSTSE NSLNVMLESH MDCM