P20L1_HUMAN
ID P20L1_HUMAN Reviewed; 1017 AA.
AC A8MW92; A8MZC9; Q86U89; Q86W43; Q96BT0; Q9H702; Q9HBK3; Q9NYR3; Q9Y381;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=PHD finger protein 20-like protein 1;
GN Name=PHF20L1; ORFNames=CGI-72;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 755-1017 (ISOFORM 1).
RC TISSUE=Brain, and Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 613-1017 (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-1017 (ISOFORM 4).
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 555-1017 (ISOFORM 1).
RA Shan Y.X., Huang C.Q., Yu L.;
RT "Cloning and characterization of a novel PHD finger gene.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-909, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-433, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [9]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-75; LYS-79; LYS-530 AND LYS-851,
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
RN [10]
RP STRUCTURE BY NMR OF 1-181 (ISOFORM 2).
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the tudor domain of PHD finger protein 20-like 1.";
RL Submitted (OCT-2007) to the PDB data bank.
CC -!- INTERACTION:
CC A8MW92; P68431: H3C12; NbExp=2; IntAct=EBI-2560834, EBI-79722;
CC A8MW92; P62805: H4C9; NbExp=2; IntAct=EBI-2560834, EBI-302023;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A8MW92-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A8MW92-2; Sequence=VSP_033781, VSP_033782, VSP_033783;
CC Name=4;
CC IsoId=A8MW92-4; Sequence=VSP_040407, VSP_040408;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD34067.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAP33690.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB15098.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=EAW92152.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK025268; BAB15098.1; ALT_INIT; mRNA.
DR EMBL; AK290506; BAF83195.1; -; mRNA.
DR EMBL; AF228727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471060; EAW92148.1; -; Genomic_DNA.
DR EMBL; CH471060; EAW92152.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC015211; AAH15211.1; -; mRNA.
DR EMBL; BC050655; AAH50655.4; -; mRNA.
DR EMBL; BC056413; AAH56413.2; -; mRNA.
DR EMBL; AF151830; AAD34067.1; ALT_INIT; mRNA.
DR EMBL; AY279109; AAP33690.1; ALT_INIT; mRNA.
DR CCDS; CCDS6367.2; -. [A8MW92-1]
DR CCDS; CCDS6368.1; -. [A8MW92-2]
DR RefSeq; NP_057102.4; NM_016018.4. [A8MW92-1]
DR RefSeq; NP_940915.1; NM_198513.1. [A8MW92-2]
DR RefSeq; XP_016869006.1; XM_017013517.1. [A8MW92-2]
DR PDB; 2EQM; NMR; -; A=1-81.
DR PDB; 2EQU; NMR; -; A=85-177.
DR PDB; 2JTF; NMR; -; A=1-74.
DR PDB; 6L0X; X-ray; 1.30 A; A/B=5-70.
DR PDB; 6L10; X-ray; 1.60 A; A/B/C/D=5-70.
DR PDB; 6L1C; X-ray; 1.58 A; A=5-70.
DR PDB; 6L1F; X-ray; 1.90 A; B=5-70.
DR PDB; 6L1I; X-ray; 1.85 A; B=5-70.
DR PDB; 6L1P; X-ray; 1.23 A; A/B/C/D=5-70.
DR PDBsum; 2EQM; -.
DR PDBsum; 2EQU; -.
DR PDBsum; 2JTF; -.
DR PDBsum; 6L0X; -.
DR PDBsum; 6L10; -.
DR PDBsum; 6L1C; -.
DR PDBsum; 6L1F; -.
DR PDBsum; 6L1I; -.
DR PDBsum; 6L1P; -.
DR AlphaFoldDB; A8MW92; -.
DR SMR; A8MW92; -.
DR BioGRID; 119294; 69.
DR IntAct; A8MW92; 31.
DR MINT; A8MW92; -.
DR STRING; 9606.ENSP00000378784; -.
DR iPTMnet; A8MW92; -.
DR PhosphoSitePlus; A8MW92; -.
DR BioMuta; PHF20L1; -.
DR EPD; A8MW92; -.
DR jPOST; A8MW92; -.
DR MassIVE; A8MW92; -.
DR MaxQB; A8MW92; -.
DR PaxDb; A8MW92; -.
DR PeptideAtlas; A8MW92; -.
DR PRIDE; A8MW92; -.
DR ProteomicsDB; 2228; -. [A8MW92-1]
DR ProteomicsDB; 2229; -. [A8MW92-2]
DR ProteomicsDB; 2230; -. [A8MW92-4]
DR ABCD; A8MW92; 1 sequenced antibody.
DR Antibodypedia; 27384; 135 antibodies from 17 providers.
DR DNASU; 51105; -.
DR Ensembl; ENST00000337920.8; ENSP00000338269.4; ENSG00000129292.21. [A8MW92-2]
DR Ensembl; ENST00000395386.7; ENSP00000378784.2; ENSG00000129292.21. [A8MW92-1]
DR Ensembl; ENST00000622263.4; ENSP00000482945.1; ENSG00000129292.21. [A8MW92-1]
DR GeneID; 51105; -.
DR KEGG; hsa:51105; -.
DR MANE-Select; ENST00000395386.7; ENSP00000378784.2; NM_016018.5; NP_057102.4.
DR UCSC; uc003ytr.4; human. [A8MW92-1]
DR CTD; 51105; -.
DR DisGeNET; 51105; -.
DR GeneCards; PHF20L1; -.
DR HGNC; HGNC:24280; PHF20L1.
DR HPA; ENSG00000129292; Low tissue specificity.
DR neXtProt; NX_A8MW92; -.
DR OpenTargets; ENSG00000129292; -.
DR PharmGKB; PA134874888; -.
DR VEuPathDB; HostDB:ENSG00000129292; -.
DR eggNOG; KOG1844; Eukaryota.
DR GeneTree; ENSGT00940000156215; -.
DR InParanoid; A8MW92; -.
DR OMA; KFKCQIP; -.
DR OrthoDB; 147824at2759; -.
DR PhylomeDB; A8MW92; -.
DR TreeFam; TF106475; -.
DR PathwayCommons; A8MW92; -.
DR SignaLink; A8MW92; -.
DR BioGRID-ORCS; 51105; 9 hits in 1077 CRISPR screens.
DR ChiTaRS; PHF20L1; human.
DR EvolutionaryTrace; A8MW92; -.
DR GenomeRNAi; 51105; -.
DR Pharos; A8MW92; Tbio.
DR PRO; PR:A8MW92; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; A8MW92; protein.
DR Bgee; ENSG00000129292; Expressed in adrenal tissue and 190 other tissues.
DR ExpressionAtlas; A8MW92; baseline and differential.
DR Genevisible; A8MW92; HS.
DR GO; GO:0044545; C:NSL complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016573; P:histone acetylation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd04508; TUDOR; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR014002; Agenet_dom_plant.
DR InterPro; IPR022255; DUF3776.
DR InterPro; IPR040477; KDM4_Tudor_2.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR043449; PHF20-like.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15856; PTHR15856; 1.
DR Pfam; PF12618; DUF3776; 1.
DR Pfam; PF02820; MBT; 1.
DR Pfam; PF18104; Tudor_2; 1.
DR SMART; SM00743; Agenet; 2.
DR SMART; SM00333; TUDOR; 2.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Isopeptide bond;
KW Metal-binding; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation;
KW Zinc; Zinc-finger.
FT CHAIN 1..1017
FT /note="PHD finger protein 20-like protein 1"
FT /id="PRO_0000336001"
FT DOMAIN 11..71
FT /note="Tudor 1"
FT DOMAIN 85..141
FT /note="Tudor 2"
FT ZN_FING 681..729
FT /note="PHD-type"
FT REGION 183..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..579
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 368
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8CCJ9"
FT MOD_RES 433
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 909
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:19608861"
FT CROSSLNK 75
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 79
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 530
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 851
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 144..169
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_033781"
FT VAR_SEQ 311
FT /note="A -> V (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_033782"
FT VAR_SEQ 312..1017
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_033783"
FT VAR_SEQ 547..573
FT /note="KRKEKDKERREKRDKDHYRPKQKKKKK -> IRSWDFSALLMKIPSYSPISL
FT SGLPES (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:10810093"
FT /id="VSP_040407"
FT VAR_SEQ 574..1017
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:10810093"
FT /id="VSP_040408"
FT STRAND 18..22
FT /evidence="ECO:0007829|PDB:6L1P"
FT TURN 24..26
FT /evidence="ECO:0007829|PDB:2JTF"
FT STRAND 28..37
FT /evidence="ECO:0007829|PDB:6L1P"
FT TURN 38..41
FT /evidence="ECO:0007829|PDB:6L1P"
FT STRAND 42..47
FT /evidence="ECO:0007829|PDB:6L1P"
FT HELIX 52..54
FT /evidence="ECO:0007829|PDB:6L1P"
FT STRAND 56..59
FT /evidence="ECO:0007829|PDB:6L1P"
FT TURN 60..62
FT /evidence="ECO:0007829|PDB:2JTF"
FT STRAND 63..67
FT /evidence="ECO:0007829|PDB:2JTF"
FT STRAND 92..96
FT /evidence="ECO:0007829|PDB:2EQU"
FT STRAND 98..111
FT /evidence="ECO:0007829|PDB:2EQU"
FT STRAND 114..120
FT /evidence="ECO:0007829|PDB:2EQU"
FT STRAND 125..128
FT /evidence="ECO:0007829|PDB:2EQU"
FT HELIX 130..132
FT /evidence="ECO:0007829|PDB:2EQU"
FT HELIX 138..140
FT /evidence="ECO:0007829|PDB:2EQU"
SQ SEQUENCE 1017 AA; 115010 MW; 6FF33736EE712836 CRC64;
MSKKPPNRPG ITFEIGARLE ALDYLQKWYP SRIEKIDYEE GKMLVHFERW SHRYDEWIYW
DSNRLRPLER PALRKEGLKD EEDFFDFKAG EEVLARWTDC RYYPAKIEAI NKEGTFTVQF
YDGVIRCLKR MHIKAMPEDA KGQVKSQHPL SWCCPIDPAG SCNQSMGSED WIALVKAAAA
AAAKNKTGSK PRTSANSNKD KDKDERKWFK VPSKKEETST CIATPDVEKK EDLPTSSETF
GLHVENVPKM VFPQPESTLS NKRKNNQGNS FQAKRARLNK ITGLLASKAV GVDGAEKKED
YNETAPMLEQ AISPKPQSQK KNEADISSSA NTQKPALLSS TLSSGKARSK KCKHESGDSS
GCIKPPKSPL SPELIQVEDL TLVSQLSSSV INKTSPPQPV NPPRPFKHSE RRRRSQRLAT
LPMPDDSVEK VSSPSPATDG KVFSISSQNQ QESSVPEVPD VAHLPLEKLG PCLPLDLSRG
SEVTAPVASD SSYRNECPRA EKEDTQMLPN PSSKAIADGR GAPAAAGISK TEKKVKLEDK
SSTAFGKRKE KDKERREKRD KDHYRPKQKK KKKKKKKSKQ HDYSDYEDSS LEFLERCSSP
LTRSSGSSLA SRSMFTEKTT TYQYPRAILS VDLSGENLSD VDFLDDSSTE SLLLSGDEYN
QDFDSTNFEE SQDEDDALNE IVRCICEMDE ENGFMIQCEE CLCWQHSVCM GLLEESIPEQ
YICYICRDPP GQRWSAKYRY DKEWLNNGRM CGLSFFKENY SHLNAKKIVS THHLLADVYG
VTEVLHGLQL KIGILKNKHH PDLHLWACSG KRKDQDQIIA GVEKKIAQDT VNREEKKYVQ
NHKEPPRLPL KMEGTYITSE HSYQKPQSFG QDCKSLADPG SSDDDDVSSL EEEQEFHMRS
KNSLQYSAKE HGMPEKNPAE GNTVFVYNDK KGTEDPGDSH LQWQLNLLTH IENVQNEVTS
RMDLIEKEVD VLESWLDFTG ELEPPDPLAR LPQLKRHIKQ LLIDMGKVQQ IATLCSV
