P20L1_MOUSE
ID P20L1_MOUSE Reviewed; 1013 AA.
AC Q8CCJ9; A6H5Y9; Q80UN6; Q8BPP8; Q8BQQ6; Q8BS11; Q8C8H9;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=PHD finger protein 20-like protein 1;
GN Name=Phf20l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 4; 7 AND 8).
RC STRAIN=C57BL/6J; TISSUE=Aorta, Cerebellum, and Vein;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
RC STRAIN=Czech II; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-368, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=8;
CC Name=6;
CC IsoId=Q8CCJ9-6; Sequence=Displayed;
CC Name=1;
CC IsoId=Q8CCJ9-1; Sequence=VSP_040411, VSP_040412, VSP_040413;
CC Name=2;
CC IsoId=Q8CCJ9-2; Sequence=VSP_033788, VSP_033789;
CC Name=3;
CC IsoId=Q8CCJ9-3; Sequence=VSP_040412, VSP_040413;
CC Name=4;
CC IsoId=Q8CCJ9-4; Sequence=VSP_033790, VSP_040414;
CC Name=5;
CC IsoId=Q8CCJ9-5; Sequence=VSP_033785, VSP_033786;
CC Name=7;
CC IsoId=Q8CCJ9-7; Sequence=VSP_040409;
CC Name=8;
CC IsoId=Q8CCJ9-8; Sequence=VSP_040410;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC30733.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC32830.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK032638; BAC27964.1; -; mRNA.
DR EMBL; AK040888; BAC30733.1; ALT_INIT; mRNA.
DR EMBL; AK046670; BAC32830.1; ALT_INIT; mRNA.
DR EMBL; AK047044; BAC32946.1; -; mRNA.
DR EMBL; AK053606; BAC35444.1; -; mRNA.
DR EMBL; BC052212; AAH52212.1; -; mRNA.
DR EMBL; BC145689; AAI45690.1; -; mRNA.
DR CCDS; CCDS49621.1; -. [Q8CCJ9-6]
DR RefSeq; NP_001074878.1; NM_001081409.1. [Q8CCJ9-6]
DR AlphaFoldDB; Q8CCJ9; -.
DR SMR; Q8CCJ9; -.
DR BioGRID; 232090; 4.
DR STRING; 10090.ENSMUSP00000035682; -.
DR iPTMnet; Q8CCJ9; -.
DR PhosphoSitePlus; Q8CCJ9; -.
DR EPD; Q8CCJ9; -.
DR jPOST; Q8CCJ9; -.
DR MaxQB; Q8CCJ9; -.
DR PaxDb; Q8CCJ9; -.
DR PeptideAtlas; Q8CCJ9; -.
DR PRIDE; Q8CCJ9; -.
DR ProteomicsDB; 294280; -. [Q8CCJ9-6]
DR ProteomicsDB; 294281; -. [Q8CCJ9-1]
DR ProteomicsDB; 294282; -. [Q8CCJ9-2]
DR ProteomicsDB; 294283; -. [Q8CCJ9-3]
DR ProteomicsDB; 294284; -. [Q8CCJ9-4]
DR ProteomicsDB; 294285; -. [Q8CCJ9-5]
DR ProteomicsDB; 294286; -. [Q8CCJ9-7]
DR ProteomicsDB; 294287; -. [Q8CCJ9-8]
DR Antibodypedia; 27384; 135 antibodies from 17 providers.
DR Ensembl; ENSMUST00000229160; ENSMUSP00000155487; ENSMUSG00000072501. [Q8CCJ9-6]
DR Ensembl; ENSMUST00000230882; ENSMUSP00000155575; ENSMUSG00000072501. [Q8CCJ9-2]
DR GeneID; 239510; -.
DR KEGG; mmu:239510; -.
DR UCSC; uc007wae.1; mouse. [Q8CCJ9-2]
DR UCSC; uc007wag.1; mouse. [Q8CCJ9-6]
DR UCSC; uc007wah.1; mouse. [Q8CCJ9-1]
DR UCSC; uc007wak.1; mouse. [Q8CCJ9-3]
DR UCSC; uc007wan.1; mouse. [Q8CCJ9-8]
DR UCSC; uc007wao.1; mouse. [Q8CCJ9-7]
DR CTD; 51105; -.
DR MGI; MGI:2444412; Phf20l1.
DR VEuPathDB; HostDB:ENSMUSG00000072501; -.
DR eggNOG; KOG1844; Eukaryota.
DR GeneTree; ENSGT00940000156215; -.
DR HOGENOM; CLU_012707_0_0_1; -.
DR InParanoid; Q8CCJ9; -.
DR OrthoDB; 147824at2759; -.
DR PhylomeDB; Q8CCJ9; -.
DR TreeFam; TF106475; -.
DR BioGRID-ORCS; 239510; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Phf20l1; mouse.
DR PRO; PR:Q8CCJ9; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8CCJ9; protein.
DR Bgee; ENSMUSG00000072501; Expressed in rostral migratory stream and 249 other tissues.
DR ExpressionAtlas; Q8CCJ9; baseline and differential.
DR Genevisible; Q8CCJ9; MM.
DR GO; GO:0044545; C:NSL complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016573; P:histone acetylation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd04508; TUDOR; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR014002; Agenet_dom_plant.
DR InterPro; IPR022255; DUF3776.
DR InterPro; IPR040477; KDM4_Tudor_2.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR043449; PHF20-like.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15856; PTHR15856; 1.
DR Pfam; PF12618; DUF3776; 1.
DR Pfam; PF02820; MBT; 1.
DR Pfam; PF18104; Tudor_2; 1.
DR SMART; SM00743; Agenet; 2.
DR SMART; SM00333; TUDOR; 2.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Isopeptide bond; Metal-binding;
KW Phosphoprotein; Reference proteome; Repeat; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..1013
FT /note="PHD finger protein 20-like protein 1"
FT /id="PRO_0000336002"
FT DOMAIN 11..71
FT /note="Tudor 1"
FT DOMAIN 85..141
FT /note="Tudor 2"
FT ZN_FING 681..729
FT /note="PHD-type"
FT REGION 183..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..579
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..852
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..906
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 368
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 432
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A8MW92"
FT MOD_RES 905
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:A8MW92"
FT CROSSLNK 75
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:A8MW92"
FT CROSSLNK 79
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:A8MW92"
FT CROSSLNK 530
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:A8MW92"
FT VAR_SEQ 1..749
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_040409"
FT VAR_SEQ 1..694
FT /note="Missing (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_040410"
FT VAR_SEQ 86..88
FT /note="DFK -> LFE (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033785"
FT VAR_SEQ 89..1013
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033786"
FT VAR_SEQ 143
FT /note="Q -> QFLFQ (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_040411"
FT VAR_SEQ 311
FT /note="A -> V (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033788"
FT VAR_SEQ 312..1013
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033789"
FT VAR_SEQ 547..550
FT /note="KRKE -> MDRK (in isoform 1 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_040412"
FT VAR_SEQ 551..1013
FT /note="Missing (in isoform 1 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_040413"
FT VAR_SEQ 732..740
FT /note="QRWSAKYRY -> EALRPVWVV (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033790"
FT VAR_SEQ 741..1013
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_040414"
FT CONFLICT 95
FT /note="A -> G (in Ref. 2; BAC32946)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1013 AA; 113860 MW; DC9496CFD267823F CRC64;
MSKKPPNRPG ITFEIGARLE ALDYLQKWYP SRIEKIDYEE GKMLVHFERW SHRYDEWIYW
DSNRLRPLER PALRKEGLKD EEELFDFKAG EEVLARWTDC RYYPAKIEAI NKEGTFTVQF
YDGVIRCLKR MHIKAMPEDA KGQVKSQHPL SWCCPIDPAG SCNQSMGSED WIALVKAAAA
AAAKNKTGTK PRASANSNKE KERDGGKWFK LPSKKAETST CIVTAEIEKK EELPTSSETF
GLHIDTVPKI VFPQPESTLT NKRKNNQGNS FQAKRARLNK ITGLLASKAV GVDGAERKED
CSATAPVLEQ AISPKPQSQK KNEAVISSSA NTQKPALLSS TLSSGKARSK KCKHESGESS
GCIKTPKSPL APELIQAKDL TLVSQLSSVI NKTSSPQPVN PPRPCKHSER RRRSQRLATL
PMPDDSLEKL SSSSSATDGK AFSISSQNQQ QSSVPEVPAI AYVPLQKLGP CLPLDLSCGS
EVTGSRTPHP SYHGGECPRE EKEETPLFAN PTSKVVSDVK GAAAATGISK TEKKVKLEEK
TSTAFGKRKE KDKEKKEKRD KDHYKPKQKK KKKKKKKSKQ HDYSDYEDSS LDFLERCSSP
LTRSSGSSLA PRSTFTEKTT TYQYPRAILS VDLSGENLSD VEFLDDSSTE SLLLSGDEYN
QDFDSTNFEE SQDEDDALNE IVRCICELDE ENGFMIQCEE CLCWQHSVCM GLLEDSIPEQ
YICYICRDPP GQRWSAKYRY DKEWLNNGRM YGLSFLKENY SHLNAKKIVS THHLLADVYG
VTEVLHGLQL KIGILKNKHH PDLHLWAYSG KRKDQDQAVA EAERKITPQD RANSEGKECV
QNHKEPALRM EETYITSEHS YQKPQSFSQD CQSLTDPGSS DDDDASSFEE DGELRVPDKS
HLLYKNRGVS EKNPASGNKV FVYNDKKGTE GPGDSHLQWQ LNLLTHIENV QNEVTSRMDL
IEKEVDVLES WLDFTGELEP PDPLARLPQL KRHLKQLLLD VGKVQQIATL CSV
