P20L1_RAT
ID P20L1_RAT Reviewed; 1015 AA.
AC Q4V9H5;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=PHD finger protein 20-like protein 1;
GN Name=Phf20l1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-368, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q4V9H5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4V9H5-2; Sequence=VSP_040415, VSP_040416, VSP_040417,
CC VSP_040418;
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DR EMBL; AABR03056473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03057010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03057503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03057556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03059315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03059948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC096896; AAH96896.1; -; mRNA.
DR RefSeq; NP_001258368.1; NM_001271439.1. [Q4V9H5-1]
DR RefSeq; XP_008763758.1; XM_008765536.2. [Q4V9H5-2]
DR AlphaFoldDB; Q4V9H5; -.
DR SMR; Q4V9H5; -.
DR STRING; 10116.ENSRNOP00000007587; -.
DR iPTMnet; Q4V9H5; -.
DR PhosphoSitePlus; Q4V9H5; -.
DR jPOST; Q4V9H5; -.
DR PaxDb; Q4V9H5; -.
DR PRIDE; Q4V9H5; -.
DR GeneID; 314964; -.
DR KEGG; rno:314964; -.
DR UCSC; RGD:1560141; rat. [Q4V9H5-1]
DR CTD; 51105; -.
DR RGD; 1560141; Phf20l1.
DR eggNOG; KOG1844; Eukaryota.
DR HOGENOM; CLU_1053614_0_0_1; -.
DR InParanoid; Q4V9H5; -.
DR OMA; YKETAPM; -.
DR OrthoDB; 147824at2759; -.
DR PhylomeDB; Q4V9H5; -.
DR TreeFam; TF106475; -.
DR PRO; PR:Q4V9H5; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000046527; Expressed in quadriceps femoris and 18 other tissues.
DR Genevisible; Q4V9H5; RN.
DR GO; GO:0044545; C:NSL complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016573; P:histone acetylation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd04508; TUDOR; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR014002; Agenet_dom_plant.
DR InterPro; IPR022255; DUF3776.
DR InterPro; IPR040477; KDM4_Tudor_2.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR043449; PHF20-like.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15856; PTHR15856; 1.
DR Pfam; PF12618; DUF3776; 1.
DR Pfam; PF02820; MBT; 1.
DR Pfam; PF18104; Tudor_2; 1.
DR SMART; SM00743; Agenet; 2.
DR SMART; SM00333; TUDOR; 2.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Isopeptide bond; Metal-binding;
KW Phosphoprotein; Reference proteome; Repeat; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..1015
FT /note="PHD finger protein 20-like protein 1"
FT /id="PRO_0000336003"
FT DOMAIN 11..71
FT /note="Tudor 1"
FT DOMAIN 85..141
FT /note="Tudor 2"
FT ZN_FING 681..729
FT /note="PHD-type"
FT REGION 183..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..579
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 368
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 432
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A8MW92"
FT MOD_RES 907
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:A8MW92"
FT CROSSLNK 75
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:A8MW92"
FT CROSSLNK 79
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:A8MW92"
FT CROSSLNK 530
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:A8MW92"
FT CROSSLNK 849
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:A8MW92"
FT VAR_SEQ 142
FT /note="G -> GQFLF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040415"
FT VAR_SEQ 240
FT /note="F -> FV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040416"
FT VAR_SEQ 311
FT /note="A -> V (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040417"
FT VAR_SEQ 312..1015
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040418"
SQ SEQUENCE 1015 AA; 114084 MW; 4E903BC422BEF08E CRC64;
MSKKPPNRPG ITFEIGARLE ALDYLQKWYP SRIEKIDYEE GKMLVHFERW SHRYDEWIYW
DSNRLRPLER PSLRKEGLKD EEDLFDFKAG EEVLARWTDC RYYPAKIEAI NKEGTFTVQF
YDGVIRCLKR MHIKAMPEDA KGQVKSQHPL SWCCPIDPAG SCNQSMGSED WIALVKAAAA
AAAKNKTGSK PRTSANSNKE KERDGGKWFK VPSKKAETST CIVTAEIEKK EELPTSSEPF
GLHIDSVPKI VFPQPESTLT NKRKNNQGNS FQAKRARLNK ITGLLASKAV GVDGAEKKED
CSATAPVLEQ AISPKPQSQK KNEAVISSSA NTQKPALLSS TLSSGKARSK KCKHESGESS
GCIKAPKSPL APELIQAKDL TLVSQLSSVI NKTSSPQPVN PPRPCKHSER RRRSQRLATL
PMPDDSLEKL SSSSSATDGK VFSISSQNQQ ESSVPEVPAI AYVPLQKLGP CLPLDLSCGS
EVTGSQAPDS SYPGGECPRE EKEETPLFAN PTSKVVSDVK GAAAATGILK TEKKVKLEEK
TSTAFGKRKE KDKERKEKRD KDHYKPKQKK KKKKKKKSKQ HDYSDYEDSS LDFLERCSSP
LTRSSGSSLA PRSTFTEKTT TYQYPRAILS VDLSGENLSD VEFLDDSSTE SLLLSGDEYN
QDFDSTNFEE SQDEDDALNE IVRCICELDE ENGFMIQCEE CLCWQHSVCM GLLEDSIPEQ
YICYICRDPP GQRWNAKYRY DKEWLNNGRM YGLSFVKENY SHLNAKKIVS THHLLADVYG
ITEVLHGLQL KIGILKNKHH PDLRLWAYSG KRKDQDQVVA GAERKVILQD TANSEGRKYV
QNHKEPPLKM EETYITSEHS YQKPQSFSQD CHSLTDPGSS DDDDVSSFEE DGELHVADNS
HLLYSVKERG VSEKNPASEN KVFVYNDKKG MEGPGDAHLQ WQLNLLTHIE NVQNEVTSRM
DLIEKEVDVL ESWLDFTGEL EPPDPLARLP QLKRHIKQLL LDMGKVQQIA TLCSV
