P210L_MOUSE
ID P210L_MOUSE Reviewed; 1881 AA.
AC Q9D2F7;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Nuclear pore membrane glycoprotein 210-like;
DE AltName: Full=Nucleoporin 210 kDa-like;
DE AltName: Full=Nucleoporin Nup210-like;
DE Flags: Precursor;
GN Name=Nup210l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-867.
RC TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NUP210 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB31846.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC121963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC145082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK019752; BAB31846.1; ALT_FRAME; mRNA.
DR CCDS; CCDS50969.1; -.
DR RefSeq; NP_084213.1; NM_029937.1.
DR AlphaFoldDB; Q9D2F7; -.
DR STRING; 10090.ENSMUSP00000029548; -.
DR GlyGen; Q9D2F7; 4 sites.
DR iPTMnet; Q9D2F7; -.
DR PhosphoSitePlus; Q9D2F7; -.
DR PaxDb; Q9D2F7; -.
DR PeptideAtlas; Q9D2F7; -.
DR PRIDE; Q9D2F7; -.
DR ProteomicsDB; 294415; -.
DR Antibodypedia; 77096; 33 antibodies from 14 providers.
DR Ensembl; ENSMUST00000029548; ENSMUSP00000029548; ENSMUSG00000027939.
DR GeneID; 77595; -.
DR KEGG; mmu:77595; -.
DR UCSC; uc012css.1; mouse.
DR CTD; 91181; -.
DR MGI; MGI:1924845; Nup210l.
DR VEuPathDB; HostDB:ENSMUSG00000027939; -.
DR eggNOG; KOG1833; Eukaryota.
DR GeneTree; ENSGT00390000009491; -.
DR HOGENOM; CLU_001205_1_1_1; -.
DR InParanoid; Q9D2F7; -.
DR OMA; YVCIIKV; -.
DR OrthoDB; 843414at2759; -.
DR PhylomeDB; Q9D2F7; -.
DR TreeFam; TF313331; -.
DR BioGRID-ORCS; 77595; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Nup210l; mouse.
DR PRO; PR:Q9D2F7; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9D2F7; protein.
DR Bgee; ENSMUSG00000027939; Expressed in spermatocyte and 19 other tissues.
DR ExpressionAtlas; Q9D2F7; baseline and differential.
DR Genevisible; Q9D2F7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0060009; P:Sertoli cell development; IMP:MGI.
DR GO; GO:0007286; P:spermatid development; IMP:MGI.
DR InterPro; IPR003343; Big_2.
DR InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR InterPro; IPR045197; NUP210-like.
DR PANTHER; PTHR23019; PTHR23019; 1.
DR Pfam; PF02368; Big_2; 1.
DR SMART; SM00635; BID_2; 2.
DR SUPFAM; SSF49373; SSF49373; 2.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..1881
FT /note="Nuclear pore membrane glycoprotein 210-like"
FT /id="PRO_0000236049"
FT TRANSMEM 1804..1824
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1078..1150
FT /note="BIG2"
FT /evidence="ECO:0000255"
FT CARBOHYD 80
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 344
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 808
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1441
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 382
FT /note="K -> E (in Ref. 2; BAB31846)"
FT /evidence="ECO:0000305"
FT CONFLICT 849..867
FT /note="HQILKVHQMKGTVLIGVNF -> TVNSLQMPQGVTKWFTLLP (in Ref.
FT 2; BAB31846)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1881 AA; 208700 MW; 78E0769B20472121 CRC64;
MIAFGAPRRR SFGLLFSLAP HLFFLFLIGT LANKLNVPQV LLPFSREPGR VPFLLEAQRG
CYIWHSTHHD AVTIQPLYEN GTSCSQRAVL VAESTQPIRL SSIILAREVV TDHELRCDVK
VDVIDNIEIV SRTRELYVDD APLELMVRAL DSKGNTFSTL AGMVFEWSIA QDNESSREEL
SSKIRILKYS EAEYSPPDYI IEMEKQERQG DVILVSGMRT GAAVVKVRIY EPFYKKVAAA
LIRLLVLENI FLIPSHDTYL LVGAYIKYRV AKMVQGRMTE VNFPLEHYTL ELQDHRLTNG
GLPSKSVALL DEKTAMVTAV QLGQTNLVFV HKNVHMRSVS GLPNSTIYVV EPGFLGFSIH
PGGRWSLEVG QVYVITVEVF DKSSTRVYIS DNLKITFQFS KEYFEEQLST SNGSYHVVKA
LKDGVVVINA TLTSSLQERN SSQPKTYQIS HQQEVKIYFP IQLKPSFLAF PHHPLGISNR
FTVQVEGGSG NFTWSSSNET VAMVTTKGVV TAGQVRGNST ILARDVQNPS RSGDIKVYVM
KLNKMELLPF QADVEIGQII EVPIAMYHVN TETKEAIAFT DCSHLPLDLN SDKQGVFTLF
KEGIQKPGAM HCSSVHIAAT SPGHTLVTVS VTGHEEHAWS SATFAAYEPL KALNPVDVAL
VTWQSVKEMV FEGGPHPWIL EPSRFFLELS MEKAEAIRVA EVRLPAKRKQ NQYVYRVLCL
ELGEQVLTFR IGNHPGVLNP SPSVEKVQVR FICAHPASML VTPMYKAPSG TQPCPLPQYN
KQLIPVSSLR DSVLELAVFD QHGRKFDNFS SLMLEWKSSN ETLAHFEDSK SVEMVARDDG
SGQTRLHGHQ ILKVHQMKGT VLIGVNFAGY SGKKSPKGIS NSPRSAGVEL ILVEDVTVQP
ENATIYNHPD VKEIFNLVEG SGYFLINSSE QDIVTITYRE AESSVQLVPA HPGFLTLEVY
DLCLAYLGPA VAQIRVSDIQ ELELDLIDKV EIGKTVLVVV RVLGSSKHPF RNKYFRNMEV
RLQLASAIVT LRLMEDQDEY SENYMLRAVT VGQTTLVAIA TDRMGKKFTS APRHIEVFPP
FRLIPEKMTL IATNMMQIMS EGGPQPQSII HFSISNQTVA VVNRRGQVTG KSVGTAVLHG
TIQTVNEDTG KVIVFSQDEV QIEVVQLQAV RILAAATRLV TATEMPVYVM GVTSTQTPFS
FSNASPLLTF HWSMSKRDVL DLVPRHSEVF LQLPAENNFA MVVHTKAAGR TTIKVTVRSE
NSSSGQLEGN LLELSDEIQI LVFEKLQLFY ANCQPEQILM PMNSQLKLHT NREGAAFVSS
RVLKCFPNSS VIEEDGGGLL RSGSIAGTAV LEVTSIEPFG VNQTTITGVQ VAPVTYLRLS
SYPKLYTAQG RTLSAFPLGM SLTFIVEFYN NIGEKFHTHN TRLYMALNRD DLLLIGPGNR
NYTYMAQAVN KGVTVVGLWD QRHPGMADYI PVAVEHAIEP DTKLIFVGDV ICFSTQLVNQ
HGEPGVWMIS TNNIVQTDTA TGVGVARNPG TATIFHNIPG VVKTFREVVV NASSRLTLSY
DLKTYLTNTP NATAFKLFIS TGRNVNLKGS CTPSQALAIE KVLLPETLML CHVQFSNTLL
DIPASKVFHI HSEFSVEKGV YVCLIKVRQE SKELRQVLSV ADTSVYGWAT LVSERGKNGM
QRILIPFIPG FYMNQSEFVL GHKDTGELRI LGVERVLESL EVFHSSPFLA VSGYKHSMLT
TGLTVYLVRI VNFTAFQQMS SPAFINVSCA LTNQQEAVIV RAKDASGADH CEDSGVFKNF
VGSYQILLFT LFAVLASTSF IFLAHNAFLN KVQTIPVVYV PTTGTTQPGS YTATCSPPHF
LSSRPPLVQS RLQHWLWSIK H
