ID   P22_ASFB7               Reviewed;         177 AA.
AC   P23169;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   23-FEB-2022, entry version 75.
DE   RecName: Full=Inner membrane protein p22;
GN   OrderedLocusNames=BA71V-005; ORFNames=KP177R;
OS   African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10498;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2325203; DOI=10.1128/jvi.64.5.2073-2081.1990;
RA   Gonzalez A., Calvo V., Almazan F., Almendral J.M., Ramirez J.C.,
RA   de la Vega I., Blasco R., Vinuela E.;
RT   "Multigene families in African swine fever virus: family 360.";
RL   J. Virol. 64:2073-2081(1990).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=1994575; DOI=10.1016/0042-6822(91)90490-3;
RA   Camacho A., Vinuela E.;
RT   "Protein p22 of African swine fever virus: an early structural protein that
RT   is incorporated into the membrane of infected cells.";
RL   Virology 181:251-257(1991).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=30185597; DOI=10.1128/jvi.01293-18;
RA   Alejo A., Matamoros T., Guerra M., Andres G.;
RT   "A Proteomic Atlas of the African Swine Fever Virus Particle.";
RL   J. Virol. 92:0-0(2018).
RN   [4]
RP   INDUCTION.
RX   PubMed=32075923; DOI=10.1128/jvi.00119-20;
RA   Cackett G., Matelska D., Sykora M., Portugal R., Malecki M., Baehler J.,
RA   Dixon L., Werner F.;
RT   "The African Swine Fever Virus Transcriptome.";
RL   J. Virol. 94:0-0(2020).
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305|PubMed:30185597};
CC       Single-pass membrane protein {ECO:0000255}. Host cell membrane
CC       {ECO:0000269|PubMed:1994575}; Single-pass membrane protein
CC       {ECO:0000255}. Note=Part of the virion inner membrane.
CC       {ECO:0000269|PubMed:30185597}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000269|PubMed:32075923}.
CC   -!- SIMILARITY: Belongs to the asfivirus inner membrane protein p22 family.
CC       {ECO:0000305}.
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DR   EMBL; U18466; AAA65240.1; -; Genomic_DNA.
DR   EMBL; M57546; AAA42681.1; -; Genomic_DNA.
DR   RefSeq; NP_042704.1; NC_001659.2.
DR   SMR; P23169; -.
DR   GeneID; 22220394; -.
DR   KEGG; vg:22220394; -.
DR   Proteomes; UP000000624; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host cell membrane; Host membrane; Late protein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Virion.
FT   CHAIN           1..177
FT                   /note="Inner membrane protein p22"
FT                   /id="PRO_0000036742"
FT   TOPO_DOM        1..7
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..177
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   177 AA;  20160 MW;  7C2EE66F13E762D1 CRC64;
     MFNIKMTIST LLIALIILVI IILVVFLYYK KQQPPKKVCK VDKDCGSGEH CVRGTCSTLS
     CLDAVKMDKR NIKIDSKISS CEFTPNFYRF TDTAADEQQE FGKTRHPIKI TPSPSESHSP
     QEVCEKYCSW GTDDCTGWEY VGDEKEGTCY VYNNPHHPVL KYGKDHIIAL PRNHKHA