ID   P23D1_HUMAN             Reviewed;         279 AA.
AC   E9PI22;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Proline-rich protein 23D1;
GN   Name=PRR23D1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
CC   -!- INTERACTION:
CC       E9PI22; Q8NA54: IQUB; NbExp=3; IntAct=EBI-23335840, EBI-10220600;
CC   -!- SIMILARITY: Belongs to the PRR23 family. {ECO:0000305}.
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DR   EMBL; AC134684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS64820.1; -.
DR   RefSeq; NP_001269407.1; NM_001282478.1.
DR   RefSeq; NP_001269408.1; NM_001282479.1.
DR   RefSeq; XP_011533018.1; XM_011534716.2.
DR   RefSeq; XP_011542113.1; XM_011543811.2.
DR   AlphaFoldDB; E9PI22; -.
DR   BioGRID; 935384; 1.
DR   BioGRID; 936210; 1.
DR   IntAct; E9PI22; 1.
DR   BioMuta; PRR23D1; -.
DR   PaxDb; E9PI22; -.
DR   PRIDE; E9PI22; -.
DR   DNASU; 100131608; -.
DR   Ensembl; ENST00000533250.2; ENSP00000436891.1; ENSG00000255251.2.
DR   Ensembl; ENST00000610320.2; ENSP00000480164.1; ENSG00000274540.2.
DR   Ensembl; ENST00000647089.1; ENSP00000496128.1; ENSG00000284870.1.
DR   GeneID; 100131608; -.
DR   GeneID; 100133251; -.
DR   KEGG; hsa:100131608; -.
DR   KEGG; hsa:100133251; -.
DR   MANE-Select; ENST00000528972.1; ENSP00000436580.1; NM_001282478.1; NP_001269407.1.
DR   MANE-Select; ENST00000533250.2; ENSP00000436891.1; NM_001282479.1; NP_001269408.1.
DR   CTD; 100131608; -.
DR   CTD; 100133251; -.
DR   GeneCards; PRR23D1; -.
DR   HGNC; HGNC:49420; PRR23D1.
DR   HPA; ENSG00000255251; Tissue enriched (epididymis).
DR   neXtProt; NX_E9PI22; -.
DR   VEuPathDB; HostDB:ENSG00000255251; -.
DR   eggNOG; ENOG502TEGA; Eukaryota.
DR   HOGENOM; CLU_1207244_0_0_1; -.
DR   InParanoid; E9PI22; -.
DR   OMA; EAAPLYH; -.
DR   OrthoDB; 1018450at2759; -.
DR   PhylomeDB; E9PI22; -.
DR   SignaLink; E9PI22; -.
DR   BioGRID-ORCS; 100131608; 21 hits in 478 CRISPR screens.
DR   BioGRID-ORCS; 100133251; 6 hits in 830 CRISPR screens.
DR   Pharos; E9PI22; Tdark.
DR   PRO; PR:E9PI22; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; E9PI22; protein.
DR   Bgee; ENSG00000255251; Expressed in right testis and 14 other tissues.
DR   Genevisible; E9PI22; HS.
DR   InterPro; IPR018903; PRR23.
DR   Pfam; PF10630; DUF2476; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..279
FT                   /note="Proline-rich protein 23D1"
FT                   /id="PRO_0000425121"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   279 AA;  31050 MW;  FFF2D2F32171055D CRC64;
     MYGYRRLRSP RDSQTEPQND NEGETSLATT QMNPPKRRQV EQGPSTGAKK PSISGAPHLN
     SYQSLELPQN QQDSGTEELM IVLEQGTEVR LSLEEVILIL APETVLQLTL ENTVLVIVPE
     HVLRSEDGLQ SPVQIQYIIP SVDDFSLEFH AQDGDISDMR RENVPFSPAE EGKAAPLYQQ
     PLMIPQANHM AGISPSFLVT PLCIPRCRAA FPQCYPLPPT PSPVGRPRPA DSSFSLHGME
     LLCTSSLRPM PPSPSPGPQV YHRVHHRPPS RARRCLFRK