P24D7_ARATH
ID P24D7_ARATH Reviewed; 212 AA.
AC Q8GYG1; Q9LMF7; Q9XI86;
DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Transmembrane emp24 domain-containing protein p24delta7;
DE AltName: Full=p24 family protein delta2a;
DE Short=p24delta2a;
DE AltName: Full=p24 family protein delta7;
DE Short=p24delta7;
DE Flags: Precursor;
GN OrderedLocusNames=At1g14010; ORFNames=F16A14.23, F7A19.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=22577184; DOI=10.1093/jxb/ers112;
RA Montesinos J.C., Sturm S., Langhans M., Hillmer S., Marcote M.J.,
RA Robinson D.G., Aniento F.;
RT "Coupled transport of Arabidopsis p24 proteins at the ER-Golgi interface.";
RL J. Exp. Bot. 63:4243-4261(2012).
RN [5]
RP GENE FAMILY, SUBCELLULAR LOCATION, AND COILED-COIL DOMAIN.
RX PubMed=22132757; DOI=10.1111/j.1600-0854.2011.01317.x;
RA Chen J., Qi X., Zheng H.;
RT "Subclass-specific localization and trafficking of Arabidopsis p24 proteins
RT in the ER-Golgi interface.";
RL Traffic 13:400-415(2012).
CC -!- FUNCTION: Involved in vesicular protein trafficking. Mainly functions
CC in the early secretory pathway. Thought to act as cargo receptor at the
CC lumenal side for incorporation of secretory cargo molecules into
CC transport vesicles and to be involved in vesicle coat formation at the
CC cytoplasmic side (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Probably oligomerizes with other members of the EMP24/GP25L
CC family. Associates with the COPI vesicle coat (coatomer). Associates
CC with the COPII vesicle coat (coatomer). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:22132757}; Single-pass type I membrane protein
CC {ECO:0000269|PubMed:22132757}. Golgi apparatus, cis-Golgi network
CC membrane {ECO:0000269|PubMed:22132757}; Single-pass type I membrane
CC protein {ECO:0000269|PubMed:22132757}. Golgi apparatus, Golgi stack
CC membrane {ECO:0000269|PubMed:22132757}; Single-pass type I membrane
CC protein {ECO:0000269|PubMed:22132757}. Note=Cycles between the
CC endoplasmic reticulum and Golgi via COPI and COPII dependent pathways.
CC {ECO:0000250}.
CC -!- DOMAIN: The cytoplasmic C-terminal domain contains a functional
CC dilysine-retrieval motif, which is involved in the retrograde Golgi-to-
CC ER transport of the protein. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD39287.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAF79411.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007576; AAD39287.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC068197; AAF79411.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29098.1; -; Genomic_DNA.
DR EMBL; AK117657; BAC42310.1; -; mRNA.
DR PIR; D86273; D86273.
DR RefSeq; NP_172854.1; NM_101267.4.
DR AlphaFoldDB; Q8GYG1; -.
DR SMR; Q8GYG1; -.
DR STRING; 3702.AT1G14010.1; -.
DR PaxDb; Q8GYG1; -.
DR PRIDE; Q8GYG1; -.
DR ProteomicsDB; 248682; -.
DR EnsemblPlants; AT1G14010.1; AT1G14010.1; AT1G14010.
DR GeneID; 837961; -.
DR Gramene; AT1G14010.1; AT1G14010.1; AT1G14010.
DR KEGG; ath:AT1G14010; -.
DR Araport; AT1G14010; -.
DR TAIR; locus:2014864; AT1G14010.
DR eggNOG; KOG1691; Eukaryota.
DR HOGENOM; CLU_066963_3_2_1; -.
DR InParanoid; Q8GYG1; -.
DR OMA; SAAFYFH; -.
DR OrthoDB; 1370889at2759; -.
DR PhylomeDB; Q8GYG1; -.
DR PRO; PR:Q8GYG1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8GYG1; baseline and differential.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR PANTHER; PTHR22811; PTHR22811; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW Membrane; Methylation; Protein transport; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..212
FT /note="Transmembrane emp24 domain-containing protein
FT p24delta7"
FT /id="PRO_0000419787"
FT TOPO_DOM 23..179
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..212
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 32..147
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT COILED 162..175
FT /evidence="ECO:0000255"
FT MOTIF 205..212
FT /note="COPI vesicle coat-binding"
FT /evidence="ECO:0000250"
FT MOTIF 205..206
FT /note="COPII vesicle coat-binding"
FT /evidence="ECO:0000250"
FT MOD_RES 165
FT /note="Omega-N-methylated arginine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 212 AA; 24156 MW; B5367242110360C0 CRC64;
MNHRRSSIVL LILSILSPVT LSIRYELLSG HTKCISEEIH ANAMTIGKYS IINPHEDHPL
PSSHKVTVRV TSPQGTAYHE SDGVESGQFS FVAVETGDYI SCFSAVDHKP ETTLIIDFDW
RTGIHTKDWS NVAKKSQVET MEFEVKKLFE TVNGIHDEMF YLRDREEEMH NLNIATNSKM
AWLSFVSLAV CLSVAGLQFW HLKTFFQKKK LI
