ID   ASF1_DICDI              Reviewed;         154 AA.
AC   Q54N45;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Histone chaperone asf1;
DE   AltName: Full=Anti-silencing function protein 1 homolog;
GN   Name=asf1; ORFNames=DDB_G0285513;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Histone chaperone that facilitates histone deposition and
CC       histone exchange and removal during nucleosome assembly and
CC       disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to
CC       promote replication-dependent chromatin assembly (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ASF1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000079; EAL64594.1; -; Genomic_DNA.
DR   RefSeq; XP_638098.1; XM_633006.1.
DR   AlphaFoldDB; Q54N45; -.
DR   SMR; Q54N45; -.
DR   STRING; 44689.DDB0266681; -.
DR   PaxDb; Q54N45; -.
DR   EnsemblProtists; EAL64594; EAL64594; DDB_G0285513.
DR   GeneID; 8625146; -.
DR   KEGG; ddi:DDB_G0285513; -.
DR   dictyBase; DDB_G0285513; asf1.
DR   eggNOG; KOG3265; Eukaryota.
DR   HOGENOM; CLU_060354_1_1_1; -.
DR   InParanoid; Q54N45; -.
DR   OMA; KINWDYG; -.
DR   PhylomeDB; Q54N45; -.
DR   PRO; PR:Q54N45; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0006334; P:nucleosome assembly; ISS:dictyBase.
DR   Gene3D; 2.60.40.1490; -; 1.
DR   InterPro; IPR006818; ASF1-like.
DR   InterPro; IPR036747; ASF1-like_sf.
DR   PANTHER; PTHR12040; PTHR12040; 1.
DR   Pfam; PF04729; ASF1_hist_chap; 1.
DR   SUPFAM; SSF101546; SSF101546; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..154
FT                   /note="Histone chaperone asf1"
FT                   /id="PRO_0000331361"
SQ   SEQUENCE   154 AA;  17523 MW;  3579A478580D1577 CRC64;
     MSHIRLTQVL IHNNPSSFNS PFIFDISFEC VSPIKEDLEW KVIYVGSADN EKNDQVLDSI
     LLGPVAVGQN QFVFEVDPPD ANKIPKDDLL GVTVVFLICA YKGEDFIRVG YYVNNDYFEQ
     ELKDNPPETP DLSKIQRNVM DDKPVVTGFP IQWN