ID   P25_BNYVS               Reviewed;         219 AA.
AC   Q65669;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   12-AUG-2020, entry version 42.
DE   RecName: Full=Protein P25;
DE   AltName: Full=25kDa protein;
OS   Beet necrotic yellow vein virus (isolate Japan/S) (BNYVV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Hepelivirales; Benyviridae; Benyvirus.
OX   NCBI_TaxID=652670;
OH   NCBI_TaxID=343494; Beta macrocarpa (Beet) (Beta vulgaris subsp. macrocarpa).
OH   NCBI_TaxID=161934; Beta vulgaris (Sugar beet).
OH   NCBI_TaxID=3562; Spinacia oleracea (Spinach).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8973531; DOI=10.1007/bf01718223;
RA   Saito M., Kiguchi T., Kusume T., Tamada T.;
RT   "Complete nucleotide sequence of the Japanese isolate S of beet necrotic
RT   yellow vein virus RNA and comparison with European isolates.";
RL   Arch. Virol. 141:2163-2175(1996).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=15269388; DOI=10.1099/vir.0.80142-0;
RA   Vetter G., Hily J.M., Klein E., Schmidlin L., Haas M., Merkle T.,
RA   Gilmer D.;
RT   "Nucleo-cytoplasmic shuttling of the beet necrotic yellow vein virus RNA-3-
RT   encoded p25 protein.";
RL   J. Gen. Virol. 85:2459-2469(2004).
RN   [3]
RP   FUNCTION, AND SUBUNIT.
RX   PubMed=17350709; DOI=10.1016/j.virusres.2006.12.019;
RA   Klein E., Link D., Schirmer A., Erhardt M., Gilmer D.;
RT   "Sequence variation within Beet necrotic yellow vein virus p25 protein
RT   influences its oligomerization and isolate pathogenicity on Tetragonia
RT   expansa.";
RL   Virus Res. 126:53-61(2007).
CC   -!- FUNCTION: Pathogenicity factor implicated in symptom exacerbation.
CC       Might function as transcription activator (Potential). {ECO:0000305}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000305|PubMed:17350709}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:15269388}.
CC       Host nucleus {ECO:0000269|PubMed:15269388}. Note=Shuttles between
CC       cytoplasm and nucleus.
CC   -!- SIMILARITY: Belongs to the benyvirus P25 protein family. {ECO:0000305}.
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DR   EMBL; D84412; BAA12346.1; -; Genomic_RNA.
DR   RefSeq; NP_612621.1; NC_003516.1.
DR   GeneID; 991089; -.
DR   KEGG; vg:991089; -.
DR   Proteomes; UP000001100; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008419; BNYVV_p25/p26.
DR   Pfam; PF05744; Benyvirus_P25; 1.
PE   1: Evidence at protein level;
KW   Activator; Host cytoplasm; Host nucleus; Reference proteome.
FT   CHAIN           1..219
FT                   /note="Protein P25"
FT                   /id="PRO_0000409659"
FT   REGION          103..146
FT                   /note="Transcription activation"
FT                   /evidence="ECO:0000255"
FT   MOTIF           57..62
FT                   /note="Nuclear localization signal"
FT   MOTIF           169..178
FT                   /note="Nuclear export signal"
SQ   SEQUENCE   219 AA;  24659 MW;  15156438229EDCF6 CRC64;
     MGDILGAVYD LGHRPYLARR TVYEDRLILS THGNVCRAIN LLTHDNRTTL VYHNNTKRIR
     FRGLLCAYRV PYCGFRALCR VMLCSLPRLC DIPINGSRDF VADPTRLDSS VNELLVSNGL
     VTHYDRVHNV PIHTDGFEVV DFTTVFRGPG NFLLPNATNF PRSTTTDQVY MVCLVNTVNC
     VLRFESELVV WVHSGLYAGD VLDVDNNVIQ APDGVDDND