ID   P2A06_ARATH             Reviewed;         392 AA.
AC   Q9FHE8;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Protein PHLOEM PROTEIN 2-LIKE A6;
DE            Short=AtPP2-A6;
DE            EC=3.2.2.6 {ECO:0000255|PROSITE-ProRule:PRU00204};
GN   Name=PP2A6; OrderedLocusNames=At5g45080; ORFNames=K17O22.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT   features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:31-63(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14993207; DOI=10.1101/gr.1515604;
RA   Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA   Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA   Weissenbach J., Salanoubat M.;
RT   "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT   combined approach to evaluate and improve Arabidopsis genome annotation.";
RL   Genome Res. 14:406-413(2004).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12529520; DOI=10.1104/pp.013086;
RA   Dinant S., Clark A.M., Zhu Y., Vilaine F., Palauqui J.-C., Kusiak C.,
RA   Thompson G.A.;
RT   "Diversity of the superfamily of phloem lectins (phloem protein 2) in
RT   angiosperms.";
RL   Plant Physiol. 131:114-128(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC         Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};
CC   -!- DOMAIN: The TIR domain mediates NAD(+) hydrolase (NADase) activity.
CC       Self-association of TIR domains is required for NADase activity.
CC       {ECO:0000255|PROSITE-ProRule:PRU00204}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BX831882; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR   EMBL; AB019224; BAB09491.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED95198.1; -; Genomic_DNA.
DR   EMBL; BX831882; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_199321.1; NM_123876.2.
DR   AlphaFoldDB; Q9FHE8; -.
DR   SMR; Q9FHE8; -.
DR   STRING; 3702.AT5G45080.1; -.
DR   PaxDb; Q9FHE8; -.
DR   PRIDE; Q9FHE8; -.
DR   ProteomicsDB; 248686; -.
DR   EnsemblPlants; AT5G45080.1; AT5G45080.1; AT5G45080.
DR   GeneID; 834539; -.
DR   Gramene; AT5G45080.1; AT5G45080.1; AT5G45080.
DR   KEGG; ath:AT5G45080; -.
DR   Araport; AT5G45080; -.
DR   TAIR; locus:2153217; AT5G45080.
DR   eggNOG; KOG0017; Eukaryota.
DR   HOGENOM; CLU_786077_0_0_1; -.
DR   InParanoid; Q9FHE8; -.
DR   OMA; WAWIFIN; -.
DR   OrthoDB; 675580at2759; -.
DR   PhylomeDB; Q9FHE8; -.
DR   PRO; PR:Q9FHE8; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FHE8; baseline and differential.
DR   Genevisible; Q9FHE8; AT.
DR   GO; GO:0030246; F:carbohydrate binding; ISS:TAIR.
DR   GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; -; 1.
DR   InterPro; IPR025886; PP2-like.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   Pfam; PF14299; PP2; 1.
DR   Pfam; PF01582; TIR; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52200; SSF52200; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; NAD; Reference proteome.
FT   CHAIN           1..392
FT                   /note="Protein PHLOEM PROTEIN 2-LIKE A6"
FT                   /id="PRO_0000285281"
FT   DOMAIN          13..180
FT                   /note="TIR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT   REGION          202..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        87
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
SQ   SEQUENCE   392 AA;  44142 MW;  8E8730F454878CA2 CRC64;
     MASSSSVVKP TPTGPQVFIC FRGADVRKHF ISFLVPALRE ANINVFIDEN EFLGSEMANL
     LTRIEESELA LVIFSVDFTR SHRCLNELAK IKERKDQGRL IVIPIFYKVK PSAVKFLEGK
     FGDNFRALER NNRHMLPITQ KWKEALESIP GSIGMPLAEQ SERTDNDFIN SMVIKIQQLL
     ENMAVRRNNE IEAQRKLVSI VPPKKPKGEA NPQGGSMVPA RKPEREASQE GSSVVPSMVP
     ARDLDITHSE KPQKWTWSTI NEAPNSAEIE IATLNKVYWL KIVGTITTEN LTPGAKYEAV
     FVVKLENNAS GWEQPVNLKL KVVQHDGDDD RVDRTENLND YIGQNWVDIL AGVFVVPPKT
     TPATIIFTMY QYEDKYKKKG LVVKGVAIRP TN