ID   P2B11_ARATH             Reviewed;         257 AA.
AC   Q949S5; Q9SSC8;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=F-box protein PP2-B11;
DE   AltName: Full=Protein PHLOEM PROTEIN 2-LIKE B11;
DE            Short=AtPP2-B11;
DE   AltName: Full=SKP1-interacting partner 12;
GN   Name=PP2B11; Synonyms=SKIP12; OrderedLocusNames=At1g80110;
GN   ORFNames=F18B13.19;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   INTERACTION WITH SKP1A/ASK1 AND SPK1B/ASK2.
RX   PubMed=12795696; DOI=10.1046/j.1365-313x.2003.01768.x;
RA   Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J.,
RA   Hellmann H., Estelle M., Somers D.E., Crosby W.L.;
RT   "Protein interaction analysis of SCF ubiquitin E3 ligase subunits from
RT   Arabidopsis.";
RL   Plant J. 34:753-767(2003).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12529520; DOI=10.1104/pp.013086;
RA   Dinant S., Clark A.M., Zhu Y., Vilaine F., Palauqui J.-C., Kusiak C.,
RA   Thompson G.A.;
RT   "Diversity of the superfamily of phloem lectins (phloem protein 2) in
RT   angiosperms.";
RL   Plant Physiol. 131:114-128(2003).
CC   -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC       complexes, which may mediate the ubiquitination and subsequent
CC       proteasomal degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of a SCF (ASK-cullin-F-box) protein ligase complex (By
CC       similarity). Interacts with SKP1A/ASK1 and SPK1B/ASK2. {ECO:0000250,
CC       ECO:0000269|PubMed:12795696}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The F-box is necessary for the interaction with ASK proteins.
CC       {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD55487.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AC009322; AAD55487.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE36358.1; -; Genomic_DNA.
DR   EMBL; AY050918; AAK93595.1; -; mRNA.
DR   EMBL; BT014882; AAT41865.1; -; mRNA.
DR   PIR; F96832; F96832.
DR   RefSeq; NP_565229.4; NM_106660.7.
DR   AlphaFoldDB; Q949S5; -.
DR   SMR; Q949S5; -.
DR   BioGRID; 29569; 8.
DR   IntAct; Q949S5; 2.
DR   STRING; 3702.AT1G80110.1; -.
DR   PaxDb; Q949S5; -.
DR   PRIDE; Q949S5; -.
DR   ProteomicsDB; 248864; -.
DR   EnsemblPlants; AT1G80110.1; AT1G80110.1; AT1G80110.
DR   GeneID; 844351; -.
DR   Gramene; AT1G80110.1; AT1G80110.1; AT1G80110.
DR   KEGG; ath:AT1G80110; -.
DR   Araport; AT1G80110; -.
DR   TAIR; locus:2016349; AT1G80110.
DR   eggNOG; ENOG502QRA4; Eukaryota.
DR   HOGENOM; CLU_050973_0_0_1; -.
DR   InParanoid; Q949S5; -.
DR   OMA; ECASKKD; -.
DR   OrthoDB; 1051457at2759; -.
DR   PhylomeDB; Q949S5; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q949S5; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q949S5; baseline and differential.
DR   Genevisible; Q949S5; AT.
DR   GO; GO:0005634; C:nucleus; HDA:TAIR.
DR   GO; GO:0030246; F:carbohydrate binding; ISS:TAIR.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR025886; PP2-like.
DR   Pfam; PF00646; F-box; 1.
DR   Pfam; PF14299; PP2; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..257
FT                   /note="F-box protein PP2-B11"
FT                   /id="PRO_0000272219"
FT   DOMAIN          1..44
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ   SEQUENCE   257 AA;  28984 MW;  3DC1A064C2445CB9 CRC64;
     MNNLPEDCIA KILSLTTPLD VCRLSAVSSI FRSAAGSDDV WNHFLPADFP AGFAAPAGLP
     TRKQLFFSLV DNPLLINGTL LSFSLERKSG NKCYMMAARA LNIVWGHEQR YWHWISLPNT
     RFGEVAELIM VWWLEITGKI NITLLSDDTL YAAYFVFKWN HSPYGFRQPV ETSLVLADTE
     STDNVVQPSM ISLMQDSGGE EGQSPVLRRD GWYEVELGQF FKRRGDLGEI EMSLKETKGP
     YEKKGLIVYG IEIRPVP