ASG1_CANAL
ID ASG1_CANAL Reviewed; 990 AA.
AC Q59LV8; A0A1D8PS84; Q59LU4;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Activator of stress genes protein 1;
GN Name=ASG1; OrderedLocusNames=CAALFM_CR02560CA;
GN ORFNames=CaO19.166, CaO19.7800;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP IDENTIFICATION.
RX PubMed=18629206; DOI=10.1002/cfg.492;
RA Maicas S., Moreno I., Nieto A., Gomez M., Sentandreu R., Valentin E.;
RT "In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear
RT cluster DNA-binding domains in Candida albicans.";
RL Comp. Funct. Genomics 6:345-356(2005).
RN [5]
RP FUNCTION.
RX PubMed=18451058; DOI=10.1099/mic.0.2007/016063-0;
RA Coste A.T., Ramsdale M., Ischer F., Sanglard D.;
RT "Divergent functions of three Candida albicans zinc-cluster transcription
RT factors (CTA4, ASG1 and CTF1) complementing pleiotropic drug resistance in
RT Saccharomyces cerevisiae.";
RL Microbiology 154:1491-1501(2008).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22073120; DOI=10.1371/journal.pone.0026962;
RA Vandeputte P., Ischer F., Sanglard D., Coste A.T.;
RT "In vivo systematic analysis of Candida albicans Zn2-Cys6 transcription
RT factors mutants for mice organ colonization.";
RL PLoS ONE 6:E26962-E26962(2011).
CC -!- FUNCTION: Transcription factor necessary to sustain growth on non-
CC fermentative carbon sources such as sodium acetate, acetic acid, or
CC ethanol. Plays a role in hyphal formation.
CC {ECO:0000269|PubMed:18451058, ECO:0000269|PubMed:22073120}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- DISRUPTION PHENOTYPE: Decreased hyphal formation.
CC {ECO:0000269|PubMed:22073120}.
CC -!- SIMILARITY: Belongs to the ASG1 family. {ECO:0000305}.
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DR EMBL; CP017630; AOW31000.1; -; Genomic_DNA.
DR RefSeq; XP_710703.2; XM_705611.2.
DR AlphaFoldDB; Q59LV8; -.
DR SMR; Q59LV8; -.
DR BioGRID; 1230780; 1.
DR STRING; 237561.Q59LV8; -.
DR PRIDE; Q59LV8; -.
DR GeneID; 3647687; -.
DR KEGG; cal:CAALFM_CR02560CA; -.
DR CGD; CAL0000181714; ASG1.
DR VEuPathDB; FungiDB:CR_02560C_A; -.
DR eggNOG; ENOG502QSY2; Eukaryota.
DR HOGENOM; CLU_010084_1_0_1; -.
DR InParanoid; Q59LV8; -.
DR OrthoDB; 289035at2759; -.
DR PRO; PR:Q59LV8; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Stress response; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..990
FT /note="Activator of stress genes protein 1"
FT /id="PRO_0000426052"
FT DNA_BIND 95..121
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 990 AA; 111683 MW; 8007D4E9DE642EDF CRC64;
MPKREIEDTQ SPYSSTGLVS TGESPKTSTS TPTSSTNNRA ATTTTNNTST TSTSLLKSNS
NLQPIAMTPS VSSTSLAINK PKSQENKRRR VTRACDTCRQ KKVKCDGKQP CIHCTVYSYK
CSYDQPNIRN KKNSGIPIPS QPSPAILQVA AQAAVAFGSN NNSSNQQSLQ SLQQQQQHVV
HQHQHQPLPA DEPIPKTNLI IFQQIINALL PKLQLNGFDP NLQFDLNKFQ KVVQYVMSKS
QTFTLNLNEI TELMQDPDSQ IPPPPPASSS SSHHRRTLSV GSFDDSSNSA VSSPREVGLH
LPSKEVALNL IYTTWNKACV LFRFYHRPSL LEEVDLLYSL DPMNYGDRQQ KFLPFLYSIL
ACGSLFSKTP YTMGTPSENE KNLEDDGFKY FLEARKLIDI SNVGDINSIQ TVVMMIIYLQ
CSARLSTCYS YIGIALRSAL KEGLHRNLTL FQNSKKKLDP IEEDTRKRLF YTIYKMDIYI
NSLLGLPRSL NEDEFDQLLP VELDDENVTR TEYLFDKQQG RLSSSGCANQ HTKLMFILSH
IIKKMYPIKV KPEEAENSSN VNYSRDRIHA KVTELEVELK NWLDNLPQEL KPIDPSSTTK
DVIDEVPEKF RLANYYLHLA FLNCQIILYR PFIHFISDSM DGSSSDPRSL IRGRNCIKVA
RMVVKLANKM IDHKLLLGTY WFSMYTIFFS IACLIYYFHF ANYNNNGQGF NYAGILFDDD
LNIDMIKKDI EIGKKVLDNL KNSSNSSLRI YNILNTMFEQ LNRRTASRSR QVTATTNSTT
TTANTNSNSN SNSQPTTLPA NFQNVNVKNT FENFDNMNHF VKKERERERE SLSQLFDNTS
MAKFESSSEI PKNVANIQRV ATPLEENNKE IGEVSGGNLT SNYMPGVFDK LDTQIFGKIL
PPYMLEKNET MNYNSNNNNS NNVNNNFNNN NNAGEVNNNS NGVAYNNNAA NWPLNNAEDG
LNLEDLFGTL GNNGNGGTSS SNGLEYLDPF
