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P2C48_ORYSJ
ID   P2C48_ORYSJ             Reviewed;         353 AA.
AC   Q6L482; A0A0N7KKM0;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Probable protein phosphatase 2C 48;
DE            Short=OsPP2C48;
DE            EC=3.1.3.16;
GN   OrderedLocusNames=Os05g0358500, LOC_Os05g29030;
GN   ORFNames=OJ1045_C06.13, OSJNBa0009L15.3;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA   Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA   Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA   Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT   "A fine physical map of the rice chromosome 5.";
RL   Mol. Genet. Genomics 274:337-345(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19021904; DOI=10.1186/1471-2164-9-550;
RA   Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.;
RT   "Genome-wide and expression analysis of protein phosphatase 2C in rice and
RT   Arabidopsis.";
RL   BMC Genomics 9:550-550(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:83421; EC=3.1.3.16;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:61977; EC=3.1.3.16;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC       Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000250};
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6L482-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6L482-2; Sequence=VSP_036270;
CC   -!- SIMILARITY: Belongs to the PP2C family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AK100777; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AC104272; AAV43855.1; -; Genomic_DNA.
DR   EMBL; AC136999; AAT38039.1; -; Genomic_DNA.
DR   EMBL; AP008211; BAF17217.1; -; Genomic_DNA.
DR   EMBL; AP014961; BAS93593.1; -; Genomic_DNA.
DR   EMBL; AK100777; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_015639910.1; XM_015784424.1. [Q6L482-2]
DR   RefSeq; XP_015639911.1; XM_015784425.1. [Q6L482-1]
DR   AlphaFoldDB; Q6L482; -.
DR   SMR; Q6L482; -.
DR   STRING; 4530.OS05T0358500-01; -.
DR   PaxDb; Q6L482; -.
DR   PRIDE; Q6L482; -.
DR   EnsemblPlants; Os05t0358500-01; Os05t0358500-01; Os05g0358500. [Q6L482-1]
DR   EnsemblPlants; Os05t0358500-02; Os05t0358500-02; Os05g0358500. [Q6L482-1]
DR   GeneID; 4338531; -.
DR   Gramene; Os05t0358500-01; Os05t0358500-01; Os05g0358500. [Q6L482-1]
DR   Gramene; Os05t0358500-02; Os05t0358500-02; Os05g0358500. [Q6L482-1]
DR   KEGG; osa:4338531; -.
DR   eggNOG; KOG0698; Eukaryota.
DR   HOGENOM; CLU_013173_6_0_1; -.
DR   InParanoid; Q6L482; -.
DR   OMA; LCHWQEA; -.
DR   OrthoDB; 1344250at2759; -.
DR   Proteomes; UP000000763; Chromosome 5.
DR   Proteomes; UP000059680; Chromosome 5.
DR   Genevisible; Q6L482; OS.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0035970; P:peptidyl-threonine dephosphorylation; IBA:GO_Central.
DR   CDD; cd00143; PP2Cc; 1.
DR   Gene3D; 3.60.40.10; -; 1.
DR   InterPro; IPR036457; PPM-type_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase_dom.
DR   Pfam; PF00481; PP2C; 1.
DR   SMART; SM00332; PP2Cc; 1.
DR   SUPFAM; SSF81606; SSF81606; 1.
DR   PROSITE; PS51746; PPM_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Hydrolase; Magnesium; Manganese; Metal-binding;
KW   Protein phosphatase; Reference proteome.
FT   CHAIN           1..353
FT                   /note="Probable protein phosphatase 2C 48"
FT                   /id="PRO_0000363295"
FT   DOMAIN          54..348
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01082"
FT   BINDING         90
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         90
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         91
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         293
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         339
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         295..353
FT                   /note="VWDVVSNEEAVQIVASAPEREKAAKRLVEFAVRAWRRKRRGIAVDDCSAICL
FT                   FFHSPPS -> DKHLNLFVFVCAAGVGRGVERGGGADRGVGAGEGEGGEAARRVRRPGM
FT                   EAQAPGHRRRRLLGDLPLLPLAAVLNNTHADTHAANKNRTRRRQCRRRR (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_036270"
SQ   SEQUENCE   353 AA;  38101 MW;  08013ADEAE50D4C2 CRC64;
     MRHISSLLQG LARSLSVGKE RKGGDGDDGK AAAATATAVL RTSGTLWGEG SETFAAVCSR
     RGEKGINQDC SIVCEGFGCE EGSVLCGIFD GHGQWGHYVA KAVRESLPPA LLRRWREAVT
     LAALIDGGEK RLCECRPDLW RQSYLAACAA VDAELRASRR LDAVHSGCTA LSLVKHGDLL
     VVANVGDSRA VLATASPDDG GGARLAAVQL TVDFKPNLPQ ERERIMECNG RVQCLADEPG
     VHRVWRPDRE GPGLAMSRAF GDYCVKDYGV ISAPEVTHRR ITAQDHFVIL ATDGVWDVVS
     NEEAVQIVAS APEREKAAKR LVEFAVRAWR RKRRGIAVDD CSAICLFFHS PPS
 
 
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