ID   ASG7_YEAS7              Reviewed;         209 AA.
AC   A6ZQG3;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Protein ASG7;
DE   AltName: Full=A-specific gene 7 protein;
GN   Name=ASG7; ORFNames=SCY_3124;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Required for receptor inhibition of inappropriately expressed
CC       a-factor receptor (STE3) in MAT a cells. Inhibits signaling by
CC       relocalizing the G protein beta-gamma (STE4-STE18) subunit to
CC       intracellular membranes. May also be a mechanism for the down-
CC       regulation of the mating pheromone response after the zygotic fusion
CC       event, promoting the transition of the new diploid cell to vegetative
CC       growth (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- INDUCTION: Induced by alpha-pheromone. Repressed by the ALPHA2-MCM1
CC       repressor (By similarity). {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDN63215.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AAFW02000044; EDN63215.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A6ZQG3; -.
DR   SMR; A6ZQG3; -.
DR   EnsemblFungi; EDN63215; EDN63215; SCY_3124.
DR   HOGENOM; CLU_114202_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Membrane; Phosphoprotein; Transmembrane; Transmembrane helix.
FT   CHAIN           1..209
FT                   /note="Protein ASG7"
FT                   /id="PRO_0000330044"
FT   TOPO_DOM        1..49
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..184
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..209
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         121
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P46993"
FT   MOD_RES         123
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P46993"
FT   MOD_RES         125
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P46993"
FT   MOD_RES         153
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P46993"
SQ   SEQUENCE   209 AA;  24949 MW;  52CCE840B71DB7AC CRC64;
     MTTLASSIEH KTKHLAAPFE NDENTWMKKY CCQCKSCKMS VPVQPWLPRF FVFGILCPVF
     WLVNLLAWWF LQYWQPHELE FHDLQEDEYP GFYEYEAITK RTVIPLKEEV LQEIRVMQNF
     SDSNSEEYYE SKDGMPSSFL NVNTEQVEDE NDTLKKYRYA FLKKVAHDVL ESHDLLRKTF
     RNWNLRSLLG LLIDSILIIF VVLLCKKSR