P2C75_ORYSJ
ID P2C75_ORYSJ Reviewed; 432 AA.
AC Q2R637; A0A0P0Y256; Q0IT39;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Probable protein phosphatase 2C 75;
DE Short=OsPP2C75;
DE EC=3.1.3.16;
GN OrderedLocusNames=Os11g0417400, LOC_Os11g22404;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19021904; DOI=10.1186/1471-2164-9-550;
RA Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.;
RT "Genome-wide and expression analysis of protein phosphatase 2C in rice and
RT Arabidopsis.";
RL BMC Genomics 9:550-550(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000250};
CC -!- SIMILARITY: Belongs to the PP2C family. {ECO:0000305}.
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DR EMBL; DP000010; ABA93159.2; -; Genomic_DNA.
DR EMBL; AP008217; BAF28126.2; -; Genomic_DNA.
DR EMBL; AP014967; BAT13771.1; -; Genomic_DNA.
DR EMBL; AK070536; BAG92015.1; -; mRNA.
DR RefSeq; XP_015617585.1; XM_015762099.1.
DR RefSeq; XP_015617586.1; XM_015762100.1.
DR RefSeq; XP_015617587.1; XM_015762101.1.
DR RefSeq; XP_015617588.1; XM_015762102.1.
DR RefSeq; XP_015617589.1; XM_015762103.1.
DR RefSeq; XP_015617590.1; XM_015762104.1.
DR RefSeq; XP_015617591.1; XM_015762105.1.
DR RefSeq; XP_015617592.1; XM_015762106.1.
DR RefSeq; XP_015617593.1; XM_015762107.1.
DR RefSeq; XP_015617594.1; XM_015762108.1.
DR RefSeq; XP_015617595.1; XM_015762109.1.
DR RefSeq; XP_015617596.1; XM_015762110.1.
DR RefSeq; XP_015617598.1; XM_015762112.1.
DR RefSeq; XP_015617599.1; XM_015762113.1.
DR RefSeq; XP_015617600.1; XM_015762114.1.
DR AlphaFoldDB; Q2R637; -.
DR SMR; Q2R637; -.
DR STRING; 4530.OS11T0417400-01; -.
DR PaxDb; Q2R637; -.
DR PRIDE; Q2R637; -.
DR EnsemblPlants; Os11t0417400-01; Os11t0417400-01; Os11g0417400.
DR GeneID; 9268201; -.
DR Gramene; Os11t0417400-01; Os11t0417400-01; Os11g0417400.
DR KEGG; osa:9268201; -.
DR eggNOG; KOG0698; Eukaryota.
DR HOGENOM; CLU_013173_6_0_1; -.
DR InParanoid; Q2R637; -.
DR OMA; ANETWRF; -.
DR OrthoDB; 1344250at2759; -.
DR Proteomes; UP000000763; Chromosome 11.
DR Proteomes; UP000059680; Chromosome 11.
DR Genevisible; Q2R637; OS.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:0035970; P:peptidyl-threonine dephosphorylation; IBA:GO_Central.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 3.60.40.10; -; 1.
DR InterPro; IPR036457; PPM-type_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase_dom.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF81606; SSF81606; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase;
KW Reference proteome.
FT CHAIN 1..432
FT /note="Probable protein phosphatase 2C 75"
FT /id="PRO_0000363322"
FT DOMAIN 44..356
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01082"
FT REGION 372..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 80
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 80
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 81
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 301
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 347
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
SQ SEQUENCE 432 AA; 47110 MW; D438E3AC09386086 CRC64;
MGTCLTTAEQ RAMEVPAASV KGGGGRRSDE EAPGRIAGNG AGNVACLFTR QGKKGTNQDA
MVAWENYNGR SDTVFCGVFD GHGPHGHLIA RKVRDILPSR LCDLIYEDCG DSPTSNSDVS
TLEENLSPYA DAECRSPTLA GQKEHQEFFN AMKESFRKAF KNVDKELKLQ RNIDSICSGT
TAVTLIKQGH DLIVGNLGDS RAVLGTRDQN DKLVAHQLTV DLKPDHPREA RRIRRCNGRV
FAHQDEPDVA RLWLPNCNSP GLAMARAFGD FCLKDFGLIS VPDVTYRQIT EKDEFIVLAT
DGVWDVLSNQ EVVDVVASCS GRFAAARSVV DLANETWRFK YPTSKTDDCA VVCLFLNKYE
VTGGLSGQPG YSPRMPALSG ITRPNSKRVT PDDVDDGSDS NVSGDERSLD GFTRLNTLLA
LPKFGDTSPT KK
