ID   P2IN_LACLA              Reviewed;         382 AA.
AC   Q9CI63;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Prophage ps2 probable integrase;
DE   AltName: Full=Int-TnX;
GN   Name=ps201; Synonyms=int201; OrderedLocusNames=LL0503; ORFNames=L102735;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=10532372; DOI=10.1023/a:1002048720611;
RA   Bolotin A., Mauger S., Malarme K., Ehrlich S.D., Sorokin A.;
RT   "Low-redundancy sequencing of the entire Lactococcus lactis IL1403
RT   genome.";
RL   Antonie Van Leeuwenhoek 76:27-76(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR   EMBL; AF320916; AAK08223.1; -; Genomic_DNA.
DR   EMBL; AE005176; AAK04601.1; -; Genomic_DNA.
DR   PIR; G86687; G86687.
DR   RefSeq; NP_266659.1; NC_002662.1.
DR   RefSeq; WP_010905403.1; NC_002662.1.
DR   AlphaFoldDB; Q9CI63; -.
DR   SMR; Q9CI63; -.
DR   STRING; 272623.L102735; -.
DR   PaxDb; Q9CI63; -.
DR   EnsemblBacteria; AAK04601; AAK04601; L102735.
DR   KEGG; lla:L102735; -.
DR   PATRIC; fig|272623.7.peg.546; -.
DR   eggNOG; COG0582; Bacteria.
DR   HOGENOM; CLU_027562_17_6_9; -.
DR   OMA; RETTYAS; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   Pfam; PF14659; Phage_int_SAM_3; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Reference proteome;
KW   Viral genome integration; Virus entry into host cell.
FT   CHAIN           1..382
FT                   /note="Prophage ps2 probable integrase"
FT                   /id="PRO_0000197560"
FT   DOMAIN          63..142
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          170..376
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        209
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        242
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        326
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        329
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        352
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        363
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   382 AA;  43958 MW;  07A4C4F02B9F738A CRC64;
     MWIENLPNGK YKYFERYRDP LTEKLKKVSV TLDKKTPRAQ KVAQAELLEK IESKINNSST
     SNAKFTDIAE EWWSFYKKSI KQSSISALQS SFNFIIDYFD KEIKISNVTS KVIQKFINDA
     DCPRSKLERS KSTLNLIFDY AVDLEYIEYN PARKAKLPKK IQTVKDLEKI QNKYLEQNEL
     KALLSELYSR PNTRRLALLA EFMSLNGCRM GEAIALKKEN YKRSERKIDI HGTLDKTVGY
     SKGVKTTPKT ASSFRTVDLS DREIEILDEI IEQNNLSKSV INDYNEMGYI FVSKRGIPLQ
     TNSFNLAIKR ANSRLKSPIN KNLSSHIFRH TLISYLAENN VPLKAIVDRV GHKDGGKTTT
     AIYTHVTENM KSSIIDILNK KN