ID   P2R3C_DANRE             Reviewed;         457 AA.
AC   Q803V3;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma;
GN   Name=ppp2r3c; ORFNames=zgc:55473;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in the regulation of cell death.
CC       {ECO:0000250|UniProtKB:Q9JK24}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JK24}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9JK24}.
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DR   EMBL; BC044178; AAH44178.1; -; mRNA.
DR   RefSeq; NP_956425.1; NM_200131.1.
DR   AlphaFoldDB; Q803V3; -.
DR   SMR; Q803V3; -.
DR   STRING; 7955.ENSDARP00000064553; -.
DR   PaxDb; Q803V3; -.
DR   GeneID; 393100; -.
DR   KEGG; dre:393100; -.
DR   CTD; 55012; -.
DR   ZFIN; ZDB-GENE-040426-715; ppp2r3c.
DR   eggNOG; KOG2562; Eukaryota.
DR   InParanoid; Q803V3; -.
DR   OrthoDB; 541286at2759; -.
DR   PhylomeDB; Q803V3; -.
DR   PRO; PR:Q803V3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0001782; P:B cell homeostasis; IBA:GO_Central.
DR   GO; GO:0030865; P:cortical cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0045579; P:positive regulation of B cell differentiation; IBA:GO_Central.
DR   GO; GO:0035303; P:regulation of dephosphorylation; IEA:InterPro.
DR   GO; GO:0043029; P:T cell homeostasis; IBA:GO_Central.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR041534; EF-hand_13.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR039865; PPP2R3C.
DR   PANTHER; PTHR12085; PTHR12085; 1.
DR   Pfam; PF17958; EF-hand_13; 1.
DR   SUPFAM; SSF47473; SSF47473; 2.
DR   PROSITE; PS00018; EF_HAND_1; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..457
FT                   /note="Serine/threonine-protein phosphatase 2A regulatory
FT                   subunit B'' subunit gamma"
FT                   /id="PRO_0000277836"
FT   DOMAIN          276..311
FT                   /note="EF-hand 1"
FT   DOMAIN          344..379
FT                   /note="EF-hand 2"
FT   BINDING         289
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
FT   BINDING         291
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
FT   BINDING         293
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
FT   BINDING         295
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
FT   BINDING         300
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
SQ   SEQUENCE   457 AA;  53332 MW;  BC1F7B293756D130 CRC64;
     MANDITAHWK DLLRKRLASL KPDGRTEEEK KAEESELFSK YYTEWKGGEK GEDDSFKHIP
     RFYYRLPAED EVLMQKLREE SRAVFLQRKS RELLDNEELQ NLWFLLDKHQ VPPTTGDEAM
     ISYESFLKVG EKAGTKCKLF FTARVYAKLL HNDPYGRISI MQFFNYVMRK VWLHQTRIGL
     SLYDVAGQGY LRESDLENYI LELIPTLPQL DGLEKSFYSF YVCTAVRKFF FFLDPLHTGK
     IKIQDILACS FLDDLLELRD EELSKESQES NWFSAPSALR VYGQYLNLDK DHNGMLSKEE
     LSRYGTGTLT SVFLDRVYQA CLTYDGEMDY KTYLDFVLAL ENRKEPAALQ YIFKLLDMEN
     KGYLNVFALN YFFRAIQEQM KIHGQEPVSF QDVKDEIFDM VKPKDPYKIT LQDLVNSGQG
     DTVSSILIDL NGFWTYENRE VLVANDTDSN AADLDDT