ID   P2R3C_XENTR             Reviewed;         448 AA.
AC   Q6DJ05;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma;
GN   Name=ppp2r3c; ORFNames=TEgg038p23.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in the regulation of cell death.
CC       {ECO:0000250|UniProtKB:Q9JK24}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JK24}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9JK24}.
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DR   EMBL; CR761377; CAJ83648.1; -; mRNA.
DR   EMBL; BC075380; AAH75380.1; -; mRNA.
DR   RefSeq; NP_001004923.1; NM_001004923.1.
DR   RefSeq; XP_012823659.1; XM_012968205.2.
DR   AlphaFoldDB; Q6DJ05; -.
DR   SMR; Q6DJ05; -.
DR   PaxDb; Q6DJ05; -.
DR   DNASU; 448305; -.
DR   Ensembl; ENSXETT00000026865; ENSXETP00000026865; ENSXETG00000012287.
DR   GeneID; 448305; -.
DR   KEGG; xtr:448305; -.
DR   CTD; 55012; -.
DR   Xenbase; XB-GENE-1002945; ppp2r3c.
DR   eggNOG; KOG2562; Eukaryota.
DR   HOGENOM; CLU_035365_1_0_1; -.
DR   InParanoid; Q6DJ05; -.
DR   OrthoDB; 541286at2759; -.
DR   PhylomeDB; Q6DJ05; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000012287; Expressed in testis and 14 other tissues.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0001782; P:B cell homeostasis; IBA:GO_Central.
DR   GO; GO:0030865; P:cortical cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0045579; P:positive regulation of B cell differentiation; IBA:GO_Central.
DR   GO; GO:0035303; P:regulation of dephosphorylation; IEA:InterPro.
DR   GO; GO:0043029; P:T cell homeostasis; IBA:GO_Central.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR041534; EF-hand_13.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR039865; PPP2R3C.
DR   PANTHER; PTHR12085; PTHR12085; 1.
DR   Pfam; PF17958; EF-hand_13; 1.
DR   SUPFAM; SSF47473; SSF47473; 2.
DR   PROSITE; PS00018; EF_HAND_1; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..448
FT                   /note="Serine/threonine-protein phosphatase 2A regulatory
FT                   subunit B'' subunit gamma"
FT                   /id="PRO_0000277837"
FT   DOMAIN          268..303
FT                   /note="EF-hand 1"
FT   DOMAIN          336..371
FT                   /note="EF-hand 2"
FT   BINDING         281
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
FT   BINDING         283
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
FT   BINDING         285
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
FT   BINDING         287
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
FT   BINDING         292
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
SQ   SEQUENCE   448 AA;  52442 MW;  540AC1E250E3562A CRC64;
     MDWKRSLKEK LRRDGYVRKS EQEMKEEEMS LFTNYYTEWK GGGKVSSAQN IPRFYYRLPA
     EDEVLQQKLR EESRAVFLQR KSRELLDNEE LQNLWFLLDK HQSPPLIGEE AMINYTNFQT
     VGEKAGEKCK TFFTSKVFSK LIPNDPYGRI SIMQFFNYVM RKVWLHQTRI GLSLYDVAGQ
     GYLRESDLEN YILELIPTLP QLDGLEKSFY SFYVCTAVRK FFFFLDPLRT GKIKIQDILA
     CSFLDDLLEL RDEDLSKESQ ESNWFSAPSA LRVYGQYLNL DKDHNGMLSK EELSRYGTGT
     LTCVFLDRVF QECLTYDGEM DYKTYLDFVL ALENRKEPAA LQYIFKLLDI ENKGSLNVFS
     LNFFFRAIQE QMKIHGQEAV SFQDVKDEIF DMVKPKDPLR ITLQDLIQSS QGDTVCSILI
     DLNGFWTYEN REVLVANDGE SPPDIDDT