ID   P2RY2_BOVIN             Reviewed;         133 AA.
AC   O18951;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=P2Y purinoceptor 2;
DE            Short=P2Y2;
DE   Flags: Fragment;
GN   Name=P2RY2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Chang A.S., Chang S.M., Schilling W.P.;
RT   "Identification of multiple P2 purinergic receptor subtypes in bovine
RT   aortic endothelial cells (BAECs).";
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for ATP and UTP coupled to G-proteins that activate
CC       a phosphatidylinositol-calcium second messenger system. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF005153; AAB62543.1; -; mRNA.
DR   AlphaFoldDB; O18951; -.
DR   SMR; O18951; -.
DR   STRING; 9913.ENSBTAP00000048441; -.
DR   PaxDb; O18951; -.
DR   eggNOG; ENOG502QSTF; Eukaryota.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0031686; F:A1 adenosine receptor binding; IBA:GO_Central.
DR   GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IEA:InterPro.
DR   GO; GO:0045030; F:G protein-coupled UTP receptor activity; IBA:GO_Central.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0070257; P:positive regulation of mucus secretion; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000356; P2Y2_rcpt.
DR   PANTHER; PTHR24231:SF17; PTHR24231:SF17; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00594; P2Y2PRNOCPTR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..>133
FT                   /note="P2Y purinoceptor 2"
FT                   /id="PRO_0000070011"
FT   TOPO_DOM        <1..26
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..74
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..116
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..>133
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         133
SQ   SEQUENCE   133 AA;  15006 MW;  301B087C62C75B69 CRC64;
     ISVHRCLGVL RPLHSLRWGR ARYARRVAFA VWVLVLYCQA PVLYFVTTST RSSRIICHDT
     SARELFSHFV AYSSVMLSLL FAAPFAVILV CYVLMARRLL KPAYGTSGGL PRAKRKSVRT
     IAIVLTVFVL CFL