ID   P2RY2_CRIGR             Reviewed;         166 AA.
AC   P58825;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2002, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=P2Y purinoceptor 2;
DE            Short=P2Y2;
DE   Flags: Fragment;
GN   Name=P2RY2;
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Chappe V., Marcet B., Gola M., Becq F., Tirard A., Verrier B.;
RT   "Involvement of P2Y2 purinoceptor in cystic fibrosis transmembrane
RT   conductance regulator activity.";
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for ATP and UTP coupled to G-proteins that activate
CC       a phosphatidylinositol-calcium second messenger system. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF314034; AAM21974.1; -; mRNA.
DR   AlphaFoldDB; P58825; -.
DR   SMR; P58825; -.
DR   STRING; 10029.XP_007616953.1; -.
DR   BindingDB; P58825; -.
DR   eggNOG; ENOG502QSTF; Eukaryota.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IEA:InterPro.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR   GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0070257; P:positive regulation of mucus secretion; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000356; P2Y2_rcpt.
DR   PANTHER; PTHR24231:SF17; PTHR24231:SF17; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00594; P2Y2PRNOCPTR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           <1..>166
FT                   /note="P2Y purinoceptor 2"
FT                   /id="PRO_0000070012"
FT   TOPO_DOM        <1..24
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..72
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..115
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..159
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..>166
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         166
SQ   SEQUENCE   166 AA;  18792 MW;  821C39234C999E55 CRC64;
     VHRCLGVLRP LHSLRWGRAR YARRVAAVVW VLVLACQAPV LYFVTTSVRG TRITCHDTSA
     RELFSHFVAY SSVMLSLLFA VPFSVILVCY VLMARRLLKP AYGTTGGLPR AKRKSVRTIA
     LVLAVFTLCF LPFHVTRTLY YSFRSLDLSC HTLNAINMAY KITRPL