ID   P2RY3_MELGA             Reviewed;         328 AA.
AC   O93361;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=P2Y purinoceptor 3;
DE            Short=P2Y3;
DE   AltName: Full=Nucleoside diphosphate receptor;
GN   Name=P2RY3;
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9730913; DOI=10.1124/mol.54.3.541;
RA   Li Q., Olesky M., Palmer R.K., Harden T.K., Nicholas R.A.;
RT   "Evidence that the p2y3 receptor is the avian homologue of the mammalian
RT   P2Y6 receptor.";
RL   Mol. Pharmacol. 54:541-546(1998).
CC   -!- FUNCTION: Receptor for extracellular UDP > ADP = UTP. The activity of
CC       this receptor is mediated by G proteins which activate a
CC       phosphatidylinositol-calcium second messenger system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF069555; AAC23863.1; -; Genomic_DNA.
DR   AlphaFoldDB; O93361; -.
DR   SMR; O93361; -.
DR   InParanoid; O93361; -.
DR   Proteomes; UP000001645; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IEA:InterPro.
DR   GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000371; P2Y3_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01065; P2Y3PRNOCPTR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..328
FT                   /note="P2Y purinoceptor 3"
FT                   /id="PRO_0000070018"
FT   TOPO_DOM        1..22
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        23..43
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        44..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..96
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..189
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..231
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        253..275
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..298
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        299..323
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        94..172
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   328 AA;  37595 MW;  B74D49B99C7164A5 CRC64;
     MSMANFTAGR NSCTFQEEFK QVLLPLVYSV VFLLGLPLNA VVIGQIWLAR KALTRTTIYM
     LNLATADLLY VCSLPLLIYN YTQKDYWPFG DFTCKFVRFQ FYTNLHGSIL FLTCISVQRY
     MGICHPLASW HKKKGKKLTW LVCAAVWFIV IAQCLPTFVF ASTGTQRNRT VCYDLSPPDR
     SASYFPYGIT LTITGFLLPF AAILACYCSM ARILCQKDEL IGLAVHKKKD KAVRMIIIVV
     IVFSISFFPF HLTKTIYLIV RSSPTLPCPT LQAFAIAYKC TRPFASMNSV LDPILFYFTQ
     RKFRESTRYL LDKMSSKWRH DHCITYGS