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P2RY4_CRIGR
ID   P2RY4_CRIGR             Reviewed;         165 AA.
AC   P58826;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2002, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=P2Y purinoceptor 4;
DE            Short=P2Y4;
DE   AltName: Full=P2Y4 metabotropic purinergic receptor;
DE   Flags: Fragment;
GN   Name=P2RY4;
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Marcet B., Verrier B.;
RT   "Molecular and functional characterization of P2Y1 and P2Y2 purinergic
RT   receptors in CHO-k1 cells.";
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for UTP and UDP coupled to G-proteins that activate
CC       a phosphatidylinositol-calcium second messenger system. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF453823; AAM21588.1; -; Genomic_DNA.
DR   AlphaFoldDB; P58826; -.
DR   SMR; P58826; -.
DR   STRING; 10029.XP_007626248.1; -.
DR   eggNOG; ENOG502QSTF; Eukaryota.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IEA:InterPro.
DR   GO; GO:0030321; P:transepithelial chloride transport; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000018; P2Y4.
DR   PANTHER; PTHR24231:SF21; PTHR24231:SF21; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01066; P2Y4PRNOCPTR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..>165
FT                   /note="P2Y purinoceptor 4"
FT                   /id="PRO_0000070019"
FT   TRANSMEM        <1..16
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        17..30
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..74
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..124
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146..>165
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         165
SQ   SEQUENCE   165 AA;  18916 MW;  647D6BF0FCFF6C53 CRC64;
     SDTLYVLSLP TLVYYYAARN HWPFGTGFCK FVRFLFYWNL YCSVLFLTCI SVHRYMGICH
     PLRALRWGRP RFASLLCLAV WLVVAGCLVP NLFFVTTSPN GTTILCHDTT RPEEFDHYVH
     FSSAVMVLLF GLPFLVTLVC YGLMARRLYR PLPGAGQSSS RLRSL
 
 
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