P2RY4_CRIGR
ID P2RY4_CRIGR Reviewed; 165 AA.
AC P58826;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=P2Y purinoceptor 4;
DE Short=P2Y4;
DE AltName: Full=P2Y4 metabotropic purinergic receptor;
DE Flags: Fragment;
GN Name=P2RY4;
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Marcet B., Verrier B.;
RT "Molecular and functional characterization of P2Y1 and P2Y2 purinergic
RT receptors in CHO-k1 cells.";
RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for UTP and UDP coupled to G-proteins that activate
CC a phosphatidylinositol-calcium second messenger system. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF453823; AAM21588.1; -; Genomic_DNA.
DR AlphaFoldDB; P58826; -.
DR SMR; P58826; -.
DR STRING; 10029.XP_007626248.1; -.
DR eggNOG; ENOG502QSTF; Eukaryota.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IEA:InterPro.
DR GO; GO:0030321; P:transepithelial chloride transport; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000018; P2Y4.
DR PANTHER; PTHR24231:SF21; PTHR24231:SF21; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01066; P2Y4PRNOCPTR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN <1..>165
FT /note="P2Y purinoceptor 4"
FT /id="PRO_0000070019"
FT TRANSMEM <1..16
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 17..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..124
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..>165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT NON_TER 165
SQ SEQUENCE 165 AA; 18916 MW; 647D6BF0FCFF6C53 CRC64;
SDTLYVLSLP TLVYYYAARN HWPFGTGFCK FVRFLFYWNL YCSVLFLTCI SVHRYMGICH
PLRALRWGRP RFASLLCLAV WLVVAGCLVP NLFFVTTSPN GTTILCHDTT RPEEFDHYVH
FSSAVMVLLF GLPFLVTLVC YGLMARRLYR PLPGAGQSSS RLRSL