ID   P2RY4_MERUN             Reviewed;         135 AA.
AC   Q99PE4;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=P2Y purinoceptor 4;
DE            Short=P2Y4;
DE   Flags: Fragment;
GN   Name=P2RY4;
OS   Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Gerbillinae; Meriones.
OX   NCBI_TaxID=10047;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Inner ear;
RX   PubMed=11401851; DOI=10.1152/ajpcell.2001.281.1.c282;
RA   Marcus D.C., Scofield M.A.;
RT   "Apical P2Y4 purinergic receptor controls K+ secretion by vestibular dark
RT   cell epithelium.";
RL   Am. J. Physiol. 281:C282-C289(2001).
CC   -!- FUNCTION: Receptor for ATP and UTP coupled to G-proteins that activate
CC       a phosphatidylinositol-calcium second messenger system. Not activated
CC       by UDP.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in brain, heart, stria vascularis and
CC       vestibular labyrinth.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF313447; AAK07560.1; -; mRNA.
DR   AlphaFoldDB; Q99PE4; -.
DR   SMR; Q99PE4; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IEA:InterPro.
DR   GO; GO:0030321; P:transepithelial chloride transport; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000018; P2Y4.
DR   PANTHER; PTHR24231:SF21; PTHR24231:SF21; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01066; P2Y4PRNOCPTR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           <1..>135
FT                   /note="P2Y purinoceptor 4"
FT                   /id="PRO_0000070021"
FT   TRANSMEM        <1..25
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..49
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..72
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        73..90
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..112
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        113..>135
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         135
SQ   SEQUENCE   135 AA;  15171 MW;  E0FF5D420AFCC68F CRC64;
     VHFSSSVMVL LFGLPFLVTL VCYGLMALRL CRPLPGAGQS SSRLRSLRTI AVVMTVFAVC
     LVPFHITRTI YYLARLLKAD CQILNIVNVV YKVTRPLASA NSCLDPLLYL FTGDKYRHQL
     QRLCRVSAPQ RRITA