ID   P2RY6_RAT               Reviewed;         328 AA.
AC   Q63371;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=P2Y purinoceptor 6;
DE            Short=P2Y6;
GN   Name=P2ry6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Aortic smooth muscle;
RX   PubMed=7592819; DOI=10.1074/jbc.270.44.26152;
RA   Chang K., Hanaoka K., Kumada M., Takuwa Y.;
RT   "Molecular cloning and functional analysis of a novel P2 nucleotide
RT   receptor.";
RL   J. Biol. Chem. 270:26152-26158(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Receptor for extracellular UTP > ADP = 2-methylthio-ATP >
CC       ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is
CC       mediated by G proteins which activate a phosphatidylinositol-calcium
CC       second messenger system. Functionally coupled to phospholipase C.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Abundantly expressed in various tissues including
CC       lung, stomach, intestine, spleen, mesentery, heart, and, most
CC       prominently, aorta.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; D63665; BAA09816.1; -; mRNA.
DR   EMBL; BC072520; AAH72520.1; -; mRNA.
DR   PIR; I55450; I55450.
DR   RefSeq; NP_476465.1; NM_057124.2.
DR   RefSeq; XP_006229773.1; XM_006229711.2.
DR   RefSeq; XP_006229774.1; XM_006229712.2.
DR   RefSeq; XP_006229775.1; XM_006229713.3.
DR   RefSeq; XP_006229776.1; XM_006229714.3.
DR   RefSeq; XP_006229777.1; XM_006229715.2.
DR   RefSeq; XP_006229778.1; XM_006229716.2.
DR   RefSeq; XP_006229779.1; XM_006229717.3.
DR   AlphaFoldDB; Q63371; -.
DR   SMR; Q63371; -.
DR   STRING; 10116.ENSRNOP00000049439; -.
DR   BindingDB; Q63371; -.
DR   ChEMBL; CHEMBL3543; -.
DR   GuidetoPHARMACOLOGY; 326; -.
DR   GlyGen; Q63371; 2 sites.
DR   PhosphoSitePlus; Q63371; -.
DR   PaxDb; Q63371; -.
DR   PRIDE; Q63371; -.
DR   Ensembl; ENSRNOT00000050227; ENSRNOP00000049439; ENSRNOG00000019270.
DR   Ensembl; ENSRNOT00000107101; ENSRNOP00000088558; ENSRNOG00000019270.
DR   Ensembl; ENSRNOT00000108172; ENSRNOP00000081429; ENSRNOG00000019270.
DR   Ensembl; ENSRNOT00000111790; ENSRNOP00000094637; ENSRNOG00000019270.
DR   Ensembl; ENSRNOT00000116084; ENSRNOP00000087971; ENSRNOG00000019270.
DR   GeneID; 117264; -.
DR   KEGG; rno:117264; -.
DR   UCSC; RGD:620269; rat.
DR   CTD; 5031; -.
DR   RGD; 620269; P2ry6.
DR   eggNOG; ENOG502QRYJ; Eukaryota.
DR   GeneTree; ENSGT01030000234621; -.
DR   HOGENOM; CLU_009579_8_2_1; -.
DR   InParanoid; Q63371; -.
DR   OMA; KWRHDHC; -.
DR   OrthoDB; 925903at2759; -.
DR   PhylomeDB; Q63371; -.
DR   TreeFam; TF330775; -.
DR   Reactome; R-RNO-416476; G alpha (q) signalling events.
DR   Reactome; R-RNO-417957; P2Y receptors.
DR   PRO; PR:Q63371; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000019270; Expressed in spleen and 19 other tissues.
DR   Genevisible; Q63371; RN.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
DR   GO; GO:0016323; C:basolateral plasma membrane; IDA:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001621; F:G protein-coupled ADP receptor activity; ISO:RGD.
DR   GO; GO:0045029; F:G protein-coupled UDP receptor activity; ISO:RGD.
DR   GO; GO:0045030; F:G protein-coupled UTP receptor activity; ISO:RGD.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; ISO:RGD.
DR   GO; GO:0071380; P:cellular response to prostaglandin E stimulus; ISO:RGD.
DR   GO; GO:0071415; P:cellular response to purine-containing compound; ISO:RGD.
DR   GO; GO:1905835; P:cellular response to pyrimidine ribonucleotide; IMP:ARUK-UCL.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006909; P:phagocytosis; IMP:ARUK-UCL.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:RGD.
DR   GO; GO:0031587; P:positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IMP:ARUK-UCL.
DR   GO; GO:0032962; P:positive regulation of inositol trisphosphate biosynthetic process; ISO:RGD.
DR   GO; GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:RGD.
DR   GO; GO:1904707; P:positive regulation of vascular associated smooth muscle cell proliferation; ISO:RGD.
DR   GO; GO:0030321; P:transepithelial chloride transport; ISO:RGD.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001973; P2Y6_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01068; P2Y6PRNOCPTR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..328
FT                   /note="P2Y purinoceptor 6"
FT                   /id="PRO_0000070030"
FT   TOPO_DOM        1..27
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..62
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        84..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..280
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..303
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        304..328
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        173
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        99..177
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   328 AA;  36677 MW;  58EBE1997038BA5B CRC64;
     MERDNGTIQA PGLPPTTCVY REDFKRLLLP PVYSVVLVVG LPLNVCVIAQ ICASRRTLTR
     SAVYTLNLAL ADLLYACSLP LLIYNYARGD HWPFGDLACR LVRFLFYANL HGSILFLTCI
     SFQRYLGICH PLAPWHKRGG RRAAWVVCGV VWLVVTAQCL PTAVFAATGI QRNRTVCYDL
     SPPILSTRYL PYGMALTVIG FLLPFTALLA CYCRMARRLC RQDGPAGPVA QERRSKAARM
     AVVVAAVFVI SFLPFHITKT AYLAVRSTPG VSCPVLETFA AAYKGTRPFA SANSVLDPIL
     FYFTQQKFRR QPHDLLQKLT AKWQRQRV