P2RY8_CHICK
ID P2RY8_CHICK Reviewed; 357 AA.
AC Q5ZI82;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=P2Y purinoceptor 8;
DE Short=P2Y8;
GN Name=P2RY8; ORFNames=RCJMB04_29g19;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Probable receptor for purines coupled to G-proteins.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AJ720902; CAG32561.1; -; mRNA.
DR RefSeq; NP_001008679.1; NM_001008679.1.
DR RefSeq; XP_015133183.1; XM_015277697.1.
DR RefSeq; XP_015133184.1; XM_015277698.1.
DR RefSeq; XP_015133185.1; XM_015277699.1.
DR AlphaFoldDB; Q5ZI82; -.
DR SMR; Q5ZI82; -.
DR STRING; 9031.ENSGALP00000026875; -.
DR PaxDb; Q5ZI82; -.
DR Ensembl; ENSGALT00000026926; ENSGALP00000026875; ENSGALG00000016687.
DR Ensembl; ENSGALT00000099472; ENSGALP00000070298; ENSGALG00000016687.
DR GeneID; 418665; -.
DR KEGG; gga:418665; -.
DR CTD; 286530; -.
DR VEuPathDB; HostDB:geneid_418665; -.
DR eggNOG; ENOG502QW5Q; Eukaryota.
DR GeneTree; ENSGT01050000244840; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q5ZI82; -.
DR OMA; GNGLSMW; -.
DR OrthoDB; 794310at2759; -.
DR PhylomeDB; Q5ZI82; -.
DR TreeFam; TF330775; -.
DR PRO; PR:Q5ZI82; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000016687; Expressed in spleen and 11 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0015057; F:thrombin-activated receptor activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:InterPro.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IBA:GO_Central.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR027669; P2Y8_rcpt.
DR InterPro; IPR003912; Protea_act_rcpt.
DR PANTHER; PTHR24232:SF25; PTHR24232:SF25; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01428; PROTEASEAR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..357
FT /note="P2Y purinoceptor 8"
FT /id="PRO_0000070032"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..357
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..174
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 357 AA; 41243 MW; B743EF1372B01CFE CRC64;
MVKNGSHLDA ETLAMLQNKA ISITLPVVYT MVAIISIPGN FFSLWVLCWH IKPKTPSVIF
MINLSITDLL LACCFPFQIF YHIQRNHWIF GKTLCSLVTV MFYSNMYSSI LTMTCISIER
YMGVVYPMKL IKWRRKRYAL GACVIMWIFL LLAFYPLEST DLTYEVKELG IITCFDVLKW
EMLPNFAAWV AFLLTLFVVL FLIPFIVTVG CYIGTIRKLI QTSSRYGNKQ KTRSIYLAII
VLSVFITCFA PNNFILLAHM IVRLFYEGSL YPAYKLTLCL SCLNNCIDPF IYYFASKEFY
QKFMQVFRPK VPLSDSLETR RESLFSGRTM SVRSMSSGPM DGLEGVKICL QRQESVF
