ID   P2SAF_CYAM1             Reviewed;         437 AA.
AC   M1VJU3;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2013, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Photosystem II stability/assembly factor HCF136, chloroplastic {ECO:0000305};
DE   AltName: Full=Photosystem II assembly protein Ycf48 {ECO:0000303|PubMed:30061392};
DE   Flags: Precursor;
GN   Name=HCF136 {ECO:0000303|PubMed:15071595};
GN   Synonyms=ycf48 {ECO:0000303|PubMed:30061392};
GN   ORFNames=CYME_CMO314C {ECO:0000312|EMBL:BAM81643.1};
OS   Cyanidioschyzon merolae (strain NIES-3377 / 10D) (Unicellular red alga).
OC   Eukaryota; Rhodophyta; Bangiophyceae; Cyanidiales; Cyanidiaceae;
OC   Cyanidioschyzon.
OX   NCBI_TaxID=280699;
RN   [1] {ECO:0000312|EMBL:BAM81643.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-3377 / 10D {ECO:0000312|EMBL:BAM81643.1};
RX   PubMed=15071595; DOI=10.1038/nature02398;
RA   Matsuzaki M., Misumi O., Shin-i T., Maruyama S., Takahara M.,
RA   Miyagishima S., Mori T., Nishida K., Yagisawa F., Nishida K., Yoshida Y.,
RA   Nishimura Y., Nakao S., Kobayashi T., Momoyama Y., Higashiyama T.,
RA   Minoda A., Sano M., Nomoto H., Oishi K., Hayashi H., Ohta F., Nishizaka S.,
RA   Haga S., Miura S., Morishita T., Kabeya Y., Terasawa K., Suzuki Y.,
RA   Ishii Y., Asakawa S., Takano H., Ohta N., Kuroiwa H., Tanaka K.,
RA   Shimizu N., Sugano S., Sato N., Nozaki H., Ogasawara N., Kohara Y.,
RA   Kuroiwa T.;
RT   "Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon
RT   merolae 10D.";
RL   Nature 428:653-657(2004).
RN   [2] {ECO:0000312|EMBL:BAM81643.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-3377 / 10D {ECO:0000312|EMBL:BAM81643.1};
RX   PubMed=17623057; DOI=10.1186/1741-7007-5-28;
RA   Nozaki H., Takano H., Misumi O., Terasawa K., Matsuzaki M., Maruyama S.,
RA   Nishida K., Yagisawa F., Yoshida Y., Fujiwara T., Takio S., Tamura K.,
RA   Chung S.J., Nakamura S., Kuroiwa H., Tanaka K., Sato N., Kuroiwa T.;
RT   "A 100%-complete sequence reveals unusually simple genomic features in the
RT   hot-spring red alga Cyanidioschyzon merolae.";
RL   BMC Biol. 5:28-28(2007).
RN   [3] {ECO:0007744|PDB:5OJ3}
RP   X-RAY CRYSTALLOGRAPHY (2.98 ANGSTROMS), AND DOMAIN.
RC   STRAIN=NIES-3377 / 10D;
RX   PubMed=30061392; DOI=10.1073/pnas.1800609115;
RA   Yu J., Knoppova J., Michoux F., Bialek W., Cota E., Shukla M.K.,
RA   Straskova A., Pascual Aznar G., Sobotka R., Komenda J., Murray J.W.,
RA   Nixon P.J.;
RT   "Ycf48 involved in the biogenesis of the oxygen-evolving photosystem II
RT   complex is a seven-bladed beta-propeller protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 115:E7824-E7833(2018).
CC   -!- FUNCTION: Essential for photosystem II (PSII) biogenesis; required for
CC       assembly of an early intermediate in PSII assembly that includes D2
CC       (psbD) and cytochrome b559. {ECO:0000250|UniProtKB:O82660}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC       {ECO:0000250|UniProtKB:O82660}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:O82660}; Lumenal side
CC       {ECO:0000250|UniProtKB:O82660}. Note=Predicted to be imported into the
CC       lumen by the Tat system. The position of the signal peptide cleavage
CC       has not been experimentally proven. {ECO:0000255|PROSITE-
CC       ProRule:PRU00648}.
CC   -!- DOMAIN: A 7-bladed beta-propeller torus, about 54 by 55 Angstroms, with
CC       a depth of about 25 Angstroms and a central pore.
CC       {ECO:0000269|PubMed:30061392}.
CC   -!- SIMILARITY: Belongs to the Ycf48 family. {ECO:0000305}.
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DR   EMBL; AP006497; BAM81643.1; -; Genomic_DNA.
DR   RefSeq; XP_005537679.1; XM_005537622.1.
DR   PDB; 5OJ3; X-ray; 2.98 A; A/B=1-437.
DR   PDBsum; 5OJ3; -.
DR   SMR; M1VJU3; -.
DR   STRING; 45157.CMO314CT; -.
DR   EnsemblPlants; CMO314CT; CMO314CT; CMO314C.
DR   GeneID; 16995794; -.
DR   Gramene; CMO314CT; CMO314CT; CMO314C.
DR   KEGG; cme:CYME_CMO314C; -.
DR   eggNOG; KOG3511; Eukaryota.
DR   HOGENOM; CLU_057027_0_0_1; -.
DR   OMA; TWVPRSI; -.
DR   OrthoDB; 1170636at2759; -.
DR   Proteomes; UP000007014; Chromosome 15.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR028203; PSII_CF48-like_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF14870; PSII_BNR; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chloroplast; Membrane; Photosynthesis; Photosystem II;
KW   Plastid; Reference proteome; Thylakoid; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000305"
FT   TRANSIT         ?..160
FT                   /note="Thylakoid"
FT                   /evidence="ECO:0000305|PubMed:30061392"
FT   CHAIN           161..437
FT                   /note="Photosystem II stability/assembly factor HCF136,
FT                   chloroplastic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00648"
FT                   /id="PRO_0000456142"
SQ   SEQUENCE   437 AA;  47506 MW;  B236D87E2E724D99 CRC64;
     MTSVSVAFTN VAGLLAHGSK SRCRNAEVLR SRSAAERASG DRQRWRICMS DGERVHAYTE
     TVVESQLGFS VSRRALLHHL ALGALAVALP RSGALVAAPL AETVRGAAWK QVPLPTESVL
     FDIDFSQKDP NHGWLVGTRG LVLETRDGGE TWEPRAFEDV EREEELNYRF SNVSFSGDEA
     WVIGKPPVML RSTDGGKNWS RILLSPKLPG EPLLVTALGP NCAEMVTSSG AIYVTENGGI
     NWKALVRETI DATLNRTISS GITGASYFTG SIVSVSRDVH GNYIAIPSRG NFFLTWVPGS
     DFWTPHARST SRRISAIGFI QNDATKGIWE TIRGGGLGFT KPNVNLNSTE TIAFDMVDSK
     TGGYGILDVA FQDDRHVWAA VGGGSMYRSD DGGKTWRRDP LVSKVGANLY KIKFFGSQRG
     FVLGADGVLL KFHPENV