P2Y14_HUMAN
ID P2Y14_HUMAN Reviewed; 338 AA.
AC Q15391; Q8IYT7;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=P2Y purinoceptor 14;
DE Short=P2Y14;
DE AltName: Full=G-protein coupled receptor 105;
DE AltName: Full=UDP-glucose receptor;
GN Name=P2RY14; Synonyms=GPR105, KIAA0001;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11524702; DOI=10.1086/323610;
RA Joensuu T., Haemaelaeinen R., Yuan B., Johnson C., Tegelberg S.,
RA Gasparini P., Zelante L., Pirvola U., Pakarinen L., Lehesjoki A.-E.,
RA de la Chapelle A., Sankila E.-M.;
RT "Mutations in a novel gene with transmembrane domains underlie Usher
RT syndrome type 3.";
RL Am. J. Hum. Genet. 69:673-684(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow;
RX PubMed=7584026; DOI=10.1093/dnares/1.1.27;
RA Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S.,
RA Nagase T., Seki N., Ishikawa K., Tabata S.;
RT "Prediction of the coding sequences of unidentified human genes. I. The
RT coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of
RT randomly sampled cDNA clones from human immature myeloid cell line KG-1.";
RL DNA Res. 1:27-35(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION.
RX PubMed=10753868; DOI=10.1074/jbc.275.15.10767;
RA Chambers J.K., Macdonald L.E., Sarau H.M., Ames R.S., Freeman K.,
RA Foley J.J., Zhu Y., McLaughlin M.M., Murdock P., McMillan L., Trill J.,
RA Swift A., Aiyar N., Taylor P., Vawter L., Naheed S., Szekeres P.,
RA Hervieu G., Scott C., Watson J.M., Murphy A.J., Duzic E., Klein C.,
RA Bergsma D.J., Wilson S., Livi G.P.;
RT "A G protein-coupled receptor for UDP-glucose.";
RL J. Biol. Chem. 275:10767-10771(2000).
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] PRO-140.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Receptor for UDP-glucose and other UDP-sugar coupled to G-
CC proteins. Not activated by ATP, ADP, UTP or ATP.
CC {ECO:0000269|PubMed:10753868}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highest expression in the placenta, adipose tissue,
CC stomach and intestine, intermediate levels in the brain, spleen, lung
CC and heart, lowest levels in the kidney.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA02791.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF456925; AAL47764.1; -; Genomic_DNA.
DR EMBL; D13626; BAA02791.2; ALT_INIT; mRNA.
DR EMBL; BC034989; AAH34989.1; -; mRNA.
DR CCDS; CCDS3156.1; -.
DR RefSeq; NP_001074924.1; NM_001081455.1.
DR RefSeq; NP_055694.3; NM_014879.3.
DR RefSeq; XP_005247979.1; XM_005247922.3.
DR RefSeq; XP_005247980.1; XM_005247923.3.
DR RefSeq; XP_011511642.1; XM_011513340.2.
DR RefSeq; XP_016863072.1; XM_017007583.1.
DR AlphaFoldDB; Q15391; -.
DR SMR; Q15391; -.
DR BioGRID; 115260; 6.
DR IntAct; Q15391; 1.
DR STRING; 9606.ENSP00000308361; -.
DR BindingDB; Q15391; -.
DR ChEMBL; CHEMBL4518; -.
DR DrugBank; DB01069; Promethazine.
DR GuidetoPHARMACOLOGY; 330; -.
DR GlyGen; Q15391; 2 sites.
DR iPTMnet; Q15391; -.
DR PhosphoSitePlus; Q15391; -.
DR BioMuta; P2RY14; -.
DR DMDM; 3122322; -.
DR jPOST; Q15391; -.
DR MassIVE; Q15391; -.
DR PaxDb; Q15391; -.
DR PeptideAtlas; Q15391; -.
DR PRIDE; Q15391; -.
DR ProteomicsDB; 60561; -.
DR Antibodypedia; 18296; 255 antibodies from 30 providers.
DR DNASU; 9934; -.
DR Ensembl; ENST00000309170.8; ENSP00000308361.3; ENSG00000174944.9.
DR Ensembl; ENST00000424796.6; ENSP00000408733.2; ENSG00000174944.9.
DR GeneID; 9934; -.
DR KEGG; hsa:9934; -.
DR MANE-Select; ENST00000309170.8; ENSP00000308361.3; NM_014879.4; NP_055694.3.
DR UCSC; uc003eyr.2; human.
DR CTD; 9934; -.
DR DisGeNET; 9934; -.
DR GeneCards; P2RY14; -.
DR HGNC; HGNC:16442; P2RY14.
DR HPA; ENSG00000174944; Tissue enhanced (placenta).
DR MIM; 610116; gene.
DR neXtProt; NX_Q15391; -.
DR OpenTargets; ENSG00000174944; -.
DR PharmGKB; PA28853; -.
DR VEuPathDB; HostDB:ENSG00000174944; -.
DR eggNOG; ENOG502R537; Eukaryota.
DR GeneTree; ENSGT01050000244982; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q15391; -.
DR OMA; VHTVNYS; -.
DR OrthoDB; 784055at2759; -.
DR PhylomeDB; Q15391; -.
DR TreeFam; TF330969; -.
DR PathwayCommons; Q15391; -.
DR Reactome; R-HSA-417957; P2Y receptors.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; Q15391; -.
DR SIGNOR; Q15391; -.
DR BioGRID-ORCS; 9934; 13 hits in 1064 CRISPR screens.
DR GenomeRNAi; 9934; -.
DR Pharos; Q15391; Tchem.
DR PRO; PR:Q15391; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q15391; protein.
DR Bgee; ENSG00000174944; Expressed in decidua and 171 other tissues.
DR ExpressionAtlas; Q15391; baseline and differential.
DR Genevisible; Q15391; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IBA:GO_Central.
DR GO; GO:0045029; F:G protein-coupled UDP receptor activity; NAS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR005466; P2Y14_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01655; UDPGLUCOSER.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..338
FT /note="P2Y purinoceptor 14"
FT /id="PRO_0000070044"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..338
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 94..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 140
FT /note="L -> P (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035767"
FT CONFLICT 54
FT /note="K -> E (in Ref. 3; AAH34989)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 338 AA; 38971 MW; 8DBE7C782CB4753D CRC64;
MINSTSTQPP DESCSQNLLI TQQIIPVLYC MVFIAGILLN GVSGWIFFYV PSSKSFIIYL
KNIVIADFVM SLTFPFKILG DSGLGPWQLN VFVCRVSAVL FYVNMYVSIV FFGLISFDRY
YKIVKPLWTS FIQSVSYSKL LSVIVWMLML LLAVPNIILT NQSVREVTQI KCIELKSELG
RKWHKASNYI FVAIFWIVFL LLIVFYTAIT KKIFKSHLKS SRNSTSVKKK SSRNIFSIVF
VFFVCFVPYH IARIPYTKSQ TEAHYSCQSK EILRYMKEFT LLLSAANVCL DPIIYFFLCQ
PFREILCKKL HIPLKAQNDL DISRIKRGNT TLESTDTL
