P2Y14_MOUSE
ID P2Y14_MOUSE Reviewed; 338 AA.
AC Q9ESG6;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=P2Y purinoceptor 14;
DE Short=P2Y14;
DE AltName: Full=G-protein coupled receptor 105;
DE AltName: Full=UDP-glucose receptor;
GN Name=P2ry14; Synonyms=Gpr105;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Lee B.C., Scadden D.T.;
RT "7 transmembrane G protein coupled receptor from hematopoietic
RT progenitors.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Olfactory epithelium, and Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for UDP-glucose coupled to G-proteins.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF177211; AAG09275.1; -; mRNA.
DR EMBL; BC028995; AAH28995.1; -; mRNA.
DR EMBL; BC058558; AAH58558.1; -; mRNA.
DR CCDS; CCDS17371.1; -.
DR RefSeq; NP_001008497.1; NM_001008497.2.
DR RefSeq; NP_001274048.1; NM_001287119.1.
DR RefSeq; NP_001274049.1; NM_001287120.1.
DR RefSeq; NP_001274050.1; NM_001287121.1.
DR RefSeq; NP_001274051.1; NM_001287122.1.
DR RefSeq; NP_001274052.1; NM_001287123.1.
DR RefSeq; NP_573463.1; NM_133200.4.
DR AlphaFoldDB; Q9ESG6; -.
DR SMR; Q9ESG6; -.
DR STRING; 10090.ENSMUSP00000088642; -.
DR BindingDB; Q9ESG6; -.
DR ChEMBL; CHEMBL1770046; -.
DR GuidetoPHARMACOLOGY; 330; -.
DR GlyGen; Q9ESG6; 2 sites.
DR iPTMnet; Q9ESG6; -.
DR PhosphoSitePlus; Q9ESG6; -.
DR EPD; Q9ESG6; -.
DR MaxQB; Q9ESG6; -.
DR PaxDb; Q9ESG6; -.
DR PRIDE; Q9ESG6; -.
DR ProteomicsDB; 294089; -.
DR Antibodypedia; 18296; 255 antibodies from 30 providers.
DR DNASU; 140795; -.
DR Ensembl; ENSMUST00000065220; ENSMUSP00000066669; ENSMUSG00000036381.
DR Ensembl; ENSMUST00000091112; ENSMUSP00000088642; ENSMUSG00000036381.
DR Ensembl; ENSMUST00000196081; ENSMUSP00000142601; ENSMUSG00000036381.
DR Ensembl; ENSMUST00000197220; ENSMUSP00000143070; ENSMUSG00000036381.
DR GeneID; 140795; -.
DR KEGG; mmu:140795; -.
DR UCSC; uc008pik.2; mouse.
DR CTD; 9934; -.
DR MGI; MGI:2155705; P2ry14.
DR VEuPathDB; HostDB:ENSMUSG00000036381; -.
DR eggNOG; ENOG502R537; Eukaryota.
DR GeneTree; ENSGT01050000244982; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q9ESG6; -.
DR OMA; CQPFRER; -.
DR PhylomeDB; Q9ESG6; -.
DR TreeFam; TF330969; -.
DR Reactome; R-MMU-417957; P2Y receptors.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 140795; 5 hits in 70 CRISPR screens.
DR ChiTaRS; P2ry14; mouse.
DR PRO; PR:Q9ESG6; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9ESG6; protein.
DR Bgee; ENSMUSG00000036381; Expressed in uterine cervix and 133 other tissues.
DR ExpressionAtlas; Q9ESG6; baseline and differential.
DR Genevisible; Q9ESG6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IMP:MGI.
DR GO; GO:0006955; P:immune response; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR005466; P2Y14_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01655; UDPGLUCOSER.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..338
FT /note="P2Y purinoceptor 14"
FT /id="PRO_0000070045"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..338
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 94..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 338 AA; 38861 MW; 4376B50622A68A4E CRC64;
MNNSTTTDPP NQPCSWNTLI TKQIIPVLYG MVFITGLLLN GISGWIFFYV PSSKSFIIYL
KNIVVADFLM GLTFPFKVLG DSGLGPWQVN VFVCRVSAVI FYVNMYVSIV FFGLISFDRY
YKIVKPLLTS IVQSVNYSKL LSVLVWMLML LLAVPNIILT NQGVKEVTKI QCMELKNELG
RKWHKASNYI FVSIFWVVFL LLIVFYTAIT RKIFKSHLKS RKNSTSVKRK SSRNIFSIVL
VFVVCFVPYH IARIPYTKSQ TEGHYSCRTK ETLLYAKEFT LLLSAANVCL DPIIYFFLCQ
PFREVLNKKL HMSLKVQNDL EVSKTKRENA IHESTDTL
