ID   P2Y14_RAT               Reviewed;         305 AA.
AC   O35881;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 131.
DE   RecName: Full=P2Y purinoceptor 14;
DE            Short=P2Y14;
DE   AltName: Full=G-protein coupled receptor 105;
DE   AltName: Full=UDP-glucose receptor;
DE   AltName: Full=VTR 15-20;
GN   Name=P2ry14; Synonyms=Gpr105;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9295203; DOI=10.1016/s0006-8993(97)00438-1;
RA   Charlton M.E., Williams A.S., Fogliano M., Sweetnam P.M., Duman R.S.;
RT   "The isolation and characterization of a novel G protein-coupled receptor
RT   regulated by immunologic challenge.";
RL   Brain Res. 764:141-148(1997).
CC   -!- FUNCTION: Receptor for UDP-glucose coupled to G-proteins.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U76206; AAB71745.1; -; mRNA.
DR   RefSeq; NP_598261.1; NM_133577.1.
DR   AlphaFoldDB; O35881; -.
DR   SMR; O35881; -.
DR   BindingDB; O35881; -.
DR   ChEMBL; CHEMBL4295660; -.
DR   GuidetoPHARMACOLOGY; 330; -.
DR   GlyGen; O35881; 2 sites.
DR   PhosphoSitePlus; O35881; -.
DR   GeneID; 171108; -.
DR   KEGG; rno:171108; -.
DR   UCSC; RGD:70912; rat.
DR   CTD; 9934; -.
DR   RGD; 70912; P2ry14.
DR   InParanoid; O35881; -.
DR   Reactome; R-RNO-417957; P2Y receptors.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   PRO; PR:O35881; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0061484; P:hematopoietic stem cell homeostasis; ISO:RGD.
DR   GO; GO:0006955; P:immune response; IMP:RGD.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR005466; P2Y14_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01655; UDPGLUCOSER.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..305
FT                   /note="P2Y purinoceptor 14"
FT                   /id="PRO_0000070046"
FT   TOPO_DOM        1..29
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..96
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..188
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        210..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..278
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        300..305
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        161
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   305 AA;  34800 MW;  640646A68ECCC7A3 CRC64;
     MDNTTTTEPP KQPCTRNTLI TQQIIPMLYC VVFITGVLLN GISGWIFFYV PSSKSFIIYL
     KNIVVADFLM GLTFPFKVLS DSGLGPWQLN VFVFRVSAVI FYVNMYVSIA FFGLISFDRY
     YKIVKPLLVS IVQSVNYSKV LSVLVWVLML LLAVPNIILT NQSVKDVTNI QCMELKNELG
     RKWHKASNYV FVSIFWIVFL LLTVFYMAIT RKIFKSHLKS RKNSISVKRK SSRNIFSIVL
     AFVACFAPYH VARIPYTKSQ TEGHYSCQAK ETLLYTKEFT LLLSAANVCL DPISISSYAS
     RLEKS