P30II_HTL1A
ID P30II_HTL1A Reviewed; 241 AA.
AC P0C214;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 02-JUN-2021, entry version 38.
DE RecName: Full=Accessory protein p30II;
OS Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Deltaretrovirus.
OX NCBI_TaxID=11926;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6304725; DOI=10.1073/pnas.80.12.3618;
RA Seiki M., Hattori S., Hirayama Y., Yoshida M.C.;
RT "Human adult T-cell leukemia virus: complete nucleotide sequence of the
RT provirus genome integrated in leukemia cell DNA.";
RL Proc. Natl. Acad. Sci. U.S.A. 80:3618-3622(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS P30II AND P13II), AND SUBCELLULAR
RP LOCATION OF P13II AND P30II.
RC STRAIN=Isolate LAF;
RX PubMed=8445734; DOI=10.1128/jvi.67.4.2360-2366.1993;
RA Koralnik I.J., Fullen J., Franchini G.;
RT "The p12I, p13II, and p30II proteins encoded by human T-cell
RT leukemia/lymphotropic virus type I open reading frames I and II are
RT localized in three different cellular compartments.";
RL J. Virol. 67:2360-2366(1993).
RN [3]
RP ALTERNATIVE SPLICING (ISOFORMS P30II AND P13II).
RC STRAIN=Isolate LAF;
RX PubMed=1528897; DOI=10.1073/pnas.89.18.8813;
RA Koralnik I.J., Gessain A., Klotman M.E., Lo Monico A., Berneman Z.N.,
RA Franchini G.;
RT "Protein isoforms encoded by the pX region of human T-cell
RT leukemia/lymphotropic virus type I.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:8813-8817(1992).
RN [4]
RP INTERACTION OF P30II WITH HUMAN CREBBP AND EP300.
RX PubMed=11559821; DOI=10.1128/jvi.75.20.9885-9895.2001;
RA Zhang W., Nisbet J.W., Albrecht B., Ding W., Kashanchi F., Bartoe J.T.,
RA Lairmore M.D.;
RT "Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by
RT binding CREB binding protein/p300.";
RL J. Virol. 75:9885-9895(2001).
RN [5]
RP FUNCTION OF P13II.
RX PubMed=12093802; DOI=10.1074/jbc.m203023200;
RA D'Agostino D.M., Ranzato L., Arrigoni G., Cavallari I., Belleudi F.,
RA Torrisi M.R., Silic-Benussi M., Ferro T., Petronilli V., Marin O.,
RA Chieco-Bianchi L., Bernardi P., Ciminale V.;
RT "Mitochondrial alterations induced by the p13II protein of human T-cell
RT leukemia virus type 1. Critical role of arginine residues.";
RL J. Biol. Chem. 277:34424-34433(2002).
RN [6]
RP FUNCTION OF P30II.
RX PubMed=14730358; DOI=10.1038/nm984;
RA Nicot C., Dundr M., Johnson J.M., Fullen J.R., Alonzo N., Fukumoto R.,
RA Princler G.L., Derse D., Misteli T., Franchini G.;
RT "HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral
RT replication.";
RL Nat. Med. 10:197-201(2004).
RN [7]
RP REVIEW.
RX PubMed=16155609; DOI=10.1038/sj.onc.1208977;
RA Nicot C., Harrod R.L., Ciminale V., Franchini G.;
RT "Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their
RT functions.";
RL Oncogene 24:6026-6034(2005).
RN [8]
RP REVIEW.
RX PubMed=15761473; DOI=10.1038/sj.cdd.4401576;
RA D'Agostino D.M., Silic-Benussi M., Hiraragi H., Lairmore M.D., Ciminale V.;
RT "The human T-cell leukemia virus type 1 p13II protein: effects on
RT mitochondrial function and cell growth.";
RL Cell Death Differ. 12:905-915(2005).
CC -!- FUNCTION: p30II is a multifunctional regulator that sequesters
CC EP300/CREBBP and down-regulates CREB-responsive element (CRE) and Tax-
CC responsive element (TRE) mediated transcription. Specifically binds and
CC represses tax/rex mRNA nuclear export. Since Tax and Rex are positive
CC regulators of viral gene expression, their inhibition by p30II reduces
CC virion production, and allows the virus to escape the host immune
CC surveillance and persist latently in an immune-competent host.
CC -!- FUNCTION: p13II increases mitochondrial permeability to monovalent
CC cations, producing a rapid, membrane potential-dependent influx of
CC potassium. This could involve a channel-forming activity. Interferes
CC with cell proliferation and transformation and promotes apoptosis
CC induced by ceramide and Fas ligand, probably using the Ras signaling.
CC -!- SUBUNIT: p30II binds to the KIX domains of CREBBP and EP300.
CC {ECO:0000269|PubMed:11559821}.
CC -!- SUBCELLULAR LOCATION: [Isoform p30II]: Host nucleus, host nucleolus
CC {ECO:0000269|PubMed:8445734}.
CC -!- SUBCELLULAR LOCATION: [Isoform p13II]: Host mitochondrion inner
CC membrane {ECO:0000269|PubMed:8445734}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=p30II;
CC IsoId=P0C214-1; Sequence=Displayed;
CC Name=p13II;
CC IsoId=P0C214-2; Sequence=VSP_021563;
CC -!- MISCELLANEOUS: HTLV-1 lineages are divided in four clades, A
CC (Cosmopolitan), B (Central African group), C (Melanesian group) and D
CC (New Central African group).
CC -!- SIMILARITY: Belongs to the HTLV-1 accessory protein p30II family.
CC {ECO:0000305}.
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DR EMBL; J02029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; L08432; -; NOT_ANNOTATED_CDS; mRNA.
DR SMR; P0C214; -.
DR Proteomes; UP000007683; Genome.
DR GO; GO:0044192; C:host cell mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008596; P30II.
DR Pfam; PF05599; Deltaretro_Tax; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Apoptosis; Host membrane; Host mitochondrion;
KW Host mitochondrion inner membrane; Host nucleus; Membrane;
KW Reference proteome; Repressor.
FT CHAIN 1..241
FT /note="Accessory protein p30II"
FT /id="PRO_0000259954"
FT REGION 79..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 73..78
FT /note="Nuclear localization signal 1"
FT /evidence="ECO:0000255"
FT MOTIF 91..98
FT /note="Nuclear localization signal 2"
FT /evidence="ECO:0000255"
FT MOTIF 175..184
FT /note="Mitochondrial targeting signal"
FT COMPBIAS 102..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..154
FT /note="Missing (in isoform p13II)"
FT /evidence="ECO:0000303|PubMed:8445734"
FT /id="VSP_021563"
FT VARIANT 27
FT /note="L -> R (in strain: Isolate LAF)"
FT VARIANT 54
FT /note="V -> I (in strain: Isolate LAF)"
FT VARIANT 91
FT /note="G -> R (in strain: Isolate LAF)"
FT VARIANT 140
FT /note="D -> G (in strain: Isolate LAF)"
FT VARIANT 149
FT /note="A -> T (in strain: Isolate LAF)"
SQ SEQUENCE 241 AA; 26740 MW; 5B07DD09BDAA1F5D CRC64;
MALCCFAFSA PCLHLRSRRS CSSCFLLATS AAFFSARLLR RAFSSSFLFK YSAVCFSSSF
SRSFFRFLFS SARRCRSRCV SPRGGAFSPG GPRRSRPRLS SSKDSKPSST ASSSSLSFNS
SSKDNSPSTN SSTSRSSGHD TGKHRNSPAD TKLTMLIISP LPRVWTESSF RIPSLRVWRL
CTRRLVPHLW GTMFGPPTSS RPTGHLSRAS DHLGPHRWTR YRLSSTVPYP STPLLPHPEN
L
