ID   P30II_HTL1C             Reviewed;         241 AA.
AC   P0CK17;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   23-FEB-2022, entry version 28.
DE   RecName: Full=Accessory protein p30II;
OS   Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Deltaretrovirus.
OX   NCBI_TaxID=11927;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2899128; DOI=10.1099/0022-1317-69-7-1695;
RA   Malik K.T.A., Even J., Karpas A.;
RT   "Molecular cloning and complete nucleotide sequence of an adult T cell
RT   leukaemia virus/human T cell leukaemia virus type I (ATLV/HTLV-I) isolate
RT   of Caribbean origin: relationship to other members of the ATLV/HTLV-I
RT   subgroup.";
RL   J. Gen. Virol. 69:1695-1710(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Chappey C.;
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: p30II is a multifunctional regulator that sequesters
CC       EP300/CREBBP and down-regulates CREB-responsive element (CRE) and Tax-
CC       responsive element (TRE) mediated transcription. Specifically binds and
CC       represses tax/rex mRNA nuclear export. Since Tax and Rex are positive
CC       regulators of viral gene expression, their inhibition by p30II reduces
CC       virion production, and allows the virus to escape the host immune
CC       surveillance and persist latently in an immune-competent host (By
CC       similarity). {ECO:0000250}.
CC   -!- FUNCTION: p13II increases mitochondrial permeability to monovalent
CC       cations, producing a rapid, membrane potential-dependent influx of
CC       potassium. This could involve a channel-forming activity. Interferes
CC       with cell proliferation and transformation and promotes apoptosis
CC       induced by ceramide and Fas ligand, probably using the Ras signaling
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: p30II binds to the KIX domains of CREBBP and EP300.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Isoform p30II]: Host nucleus, host nucleolus
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Isoform p13II]: Host mitochondrion inner
CC       membrane {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=p30II;
CC         IsoId=P0CK17-1; Sequence=Displayed;
CC       Name=p13II;
CC         IsoId=P0CK17-2; Sequence=VSP_041273;
CC   -!- MISCELLANEOUS: HTLV-1 lineages are divided in four clades, A
CC       (Cosmopolitan), B (Central African group), C (Melanesian group) and D
CC       (New Central African group).
CC   -!- SIMILARITY: Belongs to the HTLV-1 accessory protein p30II family.
CC       {ECO:0000305}.
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DR   EMBL; D13784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF033817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PRIDE; P0CK17; -.
DR   Proteomes; UP000001061; Genome.
DR   Proteomes; UP000110593; Genome.
DR   GO; GO:0044192; C:host cell mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR008596; P30II.
DR   Pfam; PF05599; Deltaretro_Tax; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Apoptosis; Host membrane; Host mitochondrion;
KW   Host mitochondrion inner membrane; Host nucleus; Membrane;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..241
FT                   /note="Accessory protein p30II"
FT                   /id="PRO_0000409222"
FT   REGION          86..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           73..78
FT                   /note="Nuclear localization signal 1"
FT                   /evidence="ECO:0000255"
FT   MOTIF           91..98
FT                   /note="Nuclear localization signal 2"
FT                   /evidence="ECO:0000255"
FT   MOTIF           175..184
FT                   /note="Mitochondrial targeting signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        102..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..154
FT                   /note="Missing (in isoform p13II)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041273"
SQ   SEQUENCE   241 AA;  26837 MW;  69B958544768ADAE CRC64;
     MALCCFAFSA PCLHLRSRRS CSSCFLRAKS AAFSSARFLR RAFSSSFLFK YSAICFSSSF
     SRSFFRFLFS SARRCRSRCV SPRGGAFPPG GPRRSRPRLS SSRDSKPSST VSSSSLSFNS
     SSKDNSPSTN SSTSRSSGHG TGKHRNSPTD TKLTMLIISP LPRVWTESSF RIPSLRVWRL
     CTRRLVPHLW GTMFGPPTSS RPTGHLSRAS DHLGPHRWTR YRLSSTVPYP STPLLPHPEN
     L