P30_TOXGO
ID P30_TOXGO Reviewed; 336 AA.
AC P13664;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Major surface antigen p30;
DE Flags: Precursor;
OS Toxoplasma gondii.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=5811;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3183382;
RA Burg J.L., Perelman D., Kasper L.H., Ware P.L., Boothroyd J.C.;
RT "Molecular analysis of the gene encoding the major surface antigen of
RT Toxoplasma gondii.";
RL J. Immunol. 141:3584-3591(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7858408;
RA Moleon I., Beuchamp P., Cesbron-Delauw M.-F., Tourvieille B.;
RT "Cloning of the gene encoding the p30 antigen of Toxoplasma gondii by PCR
RT to insert it in transgenic mice.";
RL Arch. Med. Res. 25:463-466(1994).
CC -!- SUBCELLULAR LOCATION: Parasitophorous vacuole. Note=Surface of
CC extra- and intracellular tachyzoites and also component of the
CC vesicular network within the parasitophorous vacuole.
CC -!- DEVELOPMENTAL STAGE: Detected only in rapidly dividing and invasive
CC tachyzoites.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-18 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA32245.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X14080; CAA32244.1; -; Genomic_DNA.
DR EMBL; X14080; CAA32245.1; ALT_INIT; Genomic_DNA.
DR EMBL; S76248; AAB33440.1; -; Genomic_DNA.
DR PIR; A30527; A30527.
DR PDB; 1KZQ; X-ray; 1.70 A; A/B=48-336.
DR PDB; 1YNT; X-ray; 3.10 A; F/G=50-303.
DR PDBsum; 1KZQ; -.
DR PDBsum; 1YNT; -.
DR AlphaFoldDB; P13664; -.
DR SMR; P13664; -.
DR ABCD; P13664; 3 sequenced antibodies.
DR VEuPathDB; ToxoDB:TGARI_233460; -.
DR VEuPathDB; ToxoDB:TGCAST_233460; -.
DR VEuPathDB; ToxoDB:TGCOUG_233460; -.
DR VEuPathDB; ToxoDB:TGDOM2_233460; -.
DR VEuPathDB; ToxoDB:TGFOU_233460; -.
DR VEuPathDB; ToxoDB:TGGT1_233460; -.
DR VEuPathDB; ToxoDB:TGMAS_233460; -.
DR VEuPathDB; ToxoDB:TGME49_233460; -.
DR VEuPathDB; ToxoDB:TGP89_233460; -.
DR VEuPathDB; ToxoDB:TGPRC2_233460; -.
DR VEuPathDB; ToxoDB:TGRH88_077450; -.
DR VEuPathDB; ToxoDB:TGRUB_233460; -.
DR VEuPathDB; ToxoDB:TGVAND_233460; -.
DR VEuPathDB; ToxoDB:TGVEG_233460; -.
DR EvolutionaryTrace; P13664; -.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0020003; C:symbiont-containing vacuole; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.1320; -; 2.
DR InterPro; IPR007226; SRS_dom.
DR InterPro; IPR036755; SRS_dom_sf.
DR InterPro; IPR028352; Surface_antig_SAG1.
DR Pfam; PF04092; SAG; 2.
DR PRINTS; PR01801; SURFCEANTIGN.
DR SUPFAM; SSF74877; SSF74877; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Signal.
FT SIGNAL 1..47
FT /evidence="ECO:0000255"
FT CHAIN 48..336
FT /note="Major surface antigen p30"
FT /id="PRO_0000021982"
FT STRAND 55..59
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 62..72
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 77..81
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 87..90
FT /evidence="ECO:0007829|PDB:1KZQ"
FT HELIX 91..94
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 95..98
FT /evidence="ECO:0007829|PDB:1YNT"
FT STRAND 101..103
FT /evidence="ECO:0007829|PDB:1KZQ"
FT TURN 111..113
FT /evidence="ECO:0007829|PDB:1YNT"
FT HELIX 117..119
FT /evidence="ECO:0007829|PDB:1KZQ"
FT HELIX 126..128
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 129..131
FT /evidence="ECO:0007829|PDB:1YNT"
FT TURN 136..139
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 141..144
FT /evidence="ECO:0007829|PDB:1KZQ"
FT HELIX 147..149
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 155..164
FT /evidence="ECO:0007829|PDB:1KZQ"
FT HELIX 166..168
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 170..176
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 182..184
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 187..189
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 196..203
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 210..214
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 219..225
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 228..230
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 232..235
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 240..242
FT /evidence="ECO:0007829|PDB:1KZQ"
FT HELIX 243..245
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 255..268
FT /evidence="ECO:0007829|PDB:1KZQ"
FT TURN 271..273
FT /evidence="ECO:0007829|PDB:1YNT"
FT STRAND 279..287
FT /evidence="ECO:0007829|PDB:1KZQ"
FT STRAND 289..301
FT /evidence="ECO:0007829|PDB:1KZQ"
SQ SEQUENCE 336 AA; 34829 MW; 96C7BCEB2EB97FFE CRC64;
MSVSLHHFII SSGFLTSMFP KAVRRAVTAG VFAAPTLMSF LRCGVMASDP PLVANQVVTC
PDKKSTAAVI LTPTENHFTL KCPKTALTEP PTLAYSPNRQ ICPAGTTSSC TSKAVTLSSL
IPEAEDSWWT GDSASLDTAG IKLTVPIEKF PVTTQTFVVG CIKGDDAQSC MVTVTVQARA
SSVVNNVARC SYGADSTLGP VKLSAEGPTT MTLVCGKDGV KVPQDNNQYC SGTTLTGCNE
KSFKDILPKL TENPWQGNAS SDKGATLTIK KEAFPAESKS VIIGCTGGSP EKHHCTVKLE
FAGAAGSAKS AAGTASHVSI FAMVIGLIGS IAACVA
