P32_MYCGE
ID P32_MYCGE Reviewed; 280 AA.
AC Q49417; Q49465;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=P32 adhesin;
DE AltName: Full=Cytadhesin P32;
GN OrderedLocusNames=MG318;
OS Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS (Mycoplasmoides genitalium).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=243273;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7592348; DOI=10.1128/jb.177.20.5943-5951.1995;
RA Reddy S.P., Rasmussen W.G., Baseman J.B.;
RT "Molecular cloning and characterization of an adherence-related operon of
RT Mycoplasma genitalium.";
RL J. Bacteriol. 177:5943-5951(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
CC -!- FUNCTION: Adhesin necessary for successful cytadherence and virulence.
CC -!- SUBCELLULAR LOCATION: Cell projection, attachment organelle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Integral
CC and surface exposed membrane protein that localizes to the membrane at
CC the attachment organelle. {ECO:0000250}.
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DR EMBL; L43097; AAA99945.1; -; Genomic_DNA.
DR EMBL; L43967; AAC71540.1; -; Genomic_DNA.
DR PIR; B64235; B64235.
DR RefSeq; WP_010869427.1; NC_000908.2.
DR AlphaFoldDB; Q49417; -.
DR SMR; Q49417; -.
DR STRING; 243273.MG_318; -.
DR EnsemblBacteria; AAC71540; AAC71540; MG_318.
DR KEGG; mge:MG_318; -.
DR eggNOG; COG5180; Bacteria.
DR HOGENOM; CLU_086637_0_0_14; -.
DR OMA; NNFNPRM; -.
DR OrthoDB; 2218217at2; -.
DR BioCyc; MGEN243273:G1GJ2-387-MON; -.
DR Proteomes; UP000000807; Chromosome.
DR GO; GO:0033111; C:attachment organelle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0020035; P:adhesion of symbiont to microvasculature; IEA:UniProtKB-KW.
DR InterPro; IPR009896; Cytadhesin_P30/P32.
DR Pfam; PF07271; Cytadhesin_P30; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell projection; Cytadherence; Membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Virulence.
FT CHAIN 1..280
FT /note="P32 adhesin"
FT /id="PRO_0000058133"
FT TRANSMEM 13..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 163..168
FT /note="1-1"
FT REPEAT 170..174
FT /note="2-1"
FT REPEAT 186..190
FT /note="3-1"
FT REPEAT 191..195
FT /note="1-2"
FT REPEAT 196..200
FT /note="2-2"
FT REPEAT 199..204
FT /note="1-3"
FT REPEAT 206..210
FT /note="2-3"
FT REPEAT 222..226
FT /note="3-2"
FT REPEAT 227..231
FT /note="1-4"
FT REPEAT 232..236
FT /note="2-4"
FT REPEAT 249..254
FT /note="1-5"
FT REPEAT 256..260
FT /note="2-5"
FT REPEAT 259..264
FT /note="1-6"
FT REGION 114..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..264
FT /note="6 X 5 AA repeats of [FM]-N-P-N-M-Q"
FT REGION 170..260
FT /note="5 X 5 AA repeats of R-P-G-F-N"
FT REGION 186..226
FT /note="2 X 5 AA repeats of F-N-P-R-M"
FT COMPBIAS 115..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 18
FT /note="L -> F (in Ref. 1; AAA99945)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 280 AA; 32150 MW; 0BED68C61CE89059 CRC64;
MELNGFLRYK KLFIVLALLF TTILIVSLSL LAFALVVKTN GSELGVVFHQ TEDNTTVIQG
RSIVEQPWFI PTVAGSFGFS ALAIILGLAI GLPIVKRKEK RLLEEKERQE QIAEQLQRIS
DQQEQQTVEI DPQQSQAQPS QPQVQQPLQP QFQQRVPLLR PAFNPNMQQR PGFNQPNQQF
QPHNNFNPRM NPNMQRPGFN PNMQQRPGFN QPNQQFQPHN NFNPRMNPNM QRPGFNQPHP
NQFAQPNNFN PNMQQRPGFN PNMQQRPNPS QLMPKGGLKP
