ID   P33MX_DANRE             Reviewed;         317 AA.
AC   A4QNZ7; Q32PQ0; Q6DHE4;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Putative monooxygenase p33MONOX;
DE            EC=1.-.-.-;
GN   Name=p33monox; ORFNames=zgc:123105;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18307296; DOI=10.1021/pr700667w;
RA   Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA   Slijper M., Heck A.J.R.;
RT   "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT   analysis down to a single embryo.";
RL   J. Proteome Res. 7:1555-1564(2008).
CC   -!- FUNCTION: Potential NADPH-dependent oxidoreductase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=A4QNZ7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A4QNZ7-2; Sequence=VSP_028810;
CC       Name=3;
CC         IsoId=A4QNZ7-3; Sequence=VSP_028808, VSP_028809;
CC   -!- SIMILARITY: Belongs to the P33MONOX family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH76030.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAI08033.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC076030; AAH76030.1; ALT_INIT; mRNA.
DR   EMBL; BC108032; AAI08033.1; ALT_INIT; mRNA.
DR   EMBL; BC139588; AAI39589.1; -; mRNA.
DR   RefSeq; NP_001035083.2; NM_001039994.2. [A4QNZ7-1]
DR   RefSeq; XP_005161453.1; XM_005161396.3.
DR   AlphaFoldDB; A4QNZ7; -.
DR   STRING; 7955.ENSDARP00000009313; -.
DR   iPTMnet; A4QNZ7; -.
DR   PaxDb; A4QNZ7; -.
DR   Ensembl; ENSDART00000007675; ENSDARP00000009313; ENSDARG00000003127. [A4QNZ7-1]
DR   Ensembl; ENSDART00000133099; ENSDARP00000120691; ENSDARG00000003127. [A4QNZ7-2]
DR   Ensembl; ENSDART00000186354; ENSDARP00000152044; ENSDARG00000003127. [A4QNZ7-1]
DR   GeneID; 664766; -.
DR   KEGG; dre:664766; -.
DR   ZFIN; ZDB-GENE-051113-272; zgc:123105.
DR   eggNOG; ENOG502QRB0; Eukaryota.
DR   GeneTree; ENSGT00390000000537; -.
DR   HOGENOM; CLU_079377_0_0_1; -.
DR   InParanoid; A4QNZ7; -.
DR   OMA; SPRSHNI; -.
DR   OrthoDB; 1021703at2759; -.
DR   PhylomeDB; A4QNZ7; -.
DR   TreeFam; TF332226; -.
DR   PRO; PR:A4QNZ7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000003127; Expressed in testis and 28 other tissues.
DR   ExpressionAtlas; A4QNZ7; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR026759; P33MONOX.
DR   PANTHER; PTHR28342; PTHR28342; 1.
DR   Pfam; PF15302; P33MONOX; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasm; NADP; Oxidoreductase; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..317
FT                   /note="Putative monooxygenase p33MONOX"
FT                   /id="PRO_0000307735"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          153..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..253
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         181
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18307296"
FT   VAR_SEQ         162..188
FT                   /note="KEERQPSSNQSTPAGTPQSSPKQKRRG -> SFQHGSKCCLFACVYTFKRRS
FT                   LETSVK (in isoform 3)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_028808"
FT   VAR_SEQ         189..317
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_028809"
FT   VAR_SEQ         241..247
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_028810"
SQ   SEQUENCE   317 AA;  34422 MW;  1A1BD32D62A79293 CRC64;
     MVSRPGDLPA LEAGPGSSEG LLGGMSIPAG MTRRALSYDD NLERPMSPPP SDINISNLWK
     RPVIPERKFA RLAEEDESEG GVKQSASFES TKPIPVVKAK ASSVMNSLII KQTQESMQKF
     EKQAGLTDTG YTPHKGLNAE ETRYHRLAES MHKLQMQSTD AKEERQPSSN QSTPAGTPQS
     SPKQKRRGWF NSQGSTASLT GSEMSTSSSS SVDLASAEGP IERWGVFGPR PQVSKSTTDP
     GTHPDTSGGF ALQSYKGAQK PTPMEVMKAQ ATRLAEDPTN FKAPPKMEIP TMDGKRQVTR
     PHKLKHRDMN VLTPSGF