P33MX_RAT
ID P33MX_RAT Reviewed; 304 AA.
AC Q5U2R6; Q7TP81;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Putative monooxygenase p33MONOX;
DE EC=1.-.-.-;
DE AltName: Full=liver regeneration-related protein LRRG011;
GN Name=P33monox; ORFNames=Aa2-141;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Liver;
RA Xu C.S., Li W.Q., Li Y.C., Ma H., Wang L., Wang S.F., Han H.P., Wang G.P.,
RA Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Shi J.B.,
RA Rahman S., Wang Q.N., Zhang J.B.;
RT "Liver regeneration after PH.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=21153684; DOI=10.1007/s11010-010-0690-4;
RA Mishra M., Inoue N., Heese K.;
RT "Characterizing the novel protein p33MONOX.";
RL Mol. Cell. Biochem. 350:127-134(2011).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Potential NADPH-dependent oxidoreductase. May be involved in
CC the regulation of neuronal survival, differentiation and axonal
CC outgrowth (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with NELFB, NOL12 and PRNP.
CC {ECO:0000250|UniProtKB:Q96A73}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21153684}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5U2R6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5U2R6-2; Sequence=VSP_028806, VSP_028807;
CC -!- SIMILARITY: Belongs to the P33MONOX family. {ECO:0000305}.
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DR EMBL; AY325163; AAP92564.1; -; mRNA.
DR EMBL; BC085893; AAH85893.1; -; mRNA.
DR RefSeq; NP_001014029.1; NM_001014007.1. [Q5U2R6-1]
DR AlphaFoldDB; Q5U2R6; -.
DR SMR; Q5U2R6; -.
DR STRING; 10116.ENSRNOP00000023125; -.
DR iPTMnet; Q5U2R6; -.
DR PhosphoSitePlus; Q5U2R6; -.
DR PaxDb; Q5U2R6; -.
DR Ensembl; ENSRNOT00000098242; ENSRNOP00000085391; ENSRNOG00000017133. [Q5U2R6-1]
DR GeneID; 306766; -.
DR KEGG; rno:306766; -.
DR UCSC; RGD:1359256; rat. [Q5U2R6-1]
DR RGD; 1359256; LOC306766.
DR eggNOG; ENOG502QRB0; Eukaryota.
DR GeneTree; ENSGT00390000000537; -.
DR HOGENOM; CLU_079377_0_0_1; -.
DR InParanoid; Q5U2R6; -.
DR OMA; SPRSHNI; -.
DR OrthoDB; 1021703at2759; -.
DR PhylomeDB; Q5U2R6; -.
DR TreeFam; TF332226; -.
DR PRO; PR:Q5U2R6; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Bgee; ENSRNOG00000017133; Expressed in adult mammalian kidney and 19 other tissues.
DR Genevisible; Q5U2R6; RN.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR026759; P33MONOX.
DR PANTHER; PTHR28342; PTHR28342; 1.
DR Pfam; PF15302; P33MONOX; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; NADP; Oxidoreductase; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..304
FT /note="Putative monooxygenase p33MONOX"
FT /id="PRO_0000307733"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 38..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 69..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 68..78
FT /note="Flavin-containing monooxygenase motif"
FT COMPBIAS 77..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 45
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9DBN4"
FT MOD_RES 183
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96A73"
FT MOD_RES 184
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT VAR_SEQ 1..39
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_028806"
FT VAR_SEQ 40..54
FT /note="DPAPMTPPPSDMGSI -> MEPVTKTPELTWAAS (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_028807"
SQ SEQUENCE 304 AA; 32797 MW; FD2D14A5894D266F CRC64;
MASRQPEVPP ALAPSGPLSK MSLPIGMCRR AFSYDDALED PAPMTPPPSD MGSIPWKPVI
PERKYQHLDK TEEGAASVSS LAVTPSTATD SSDKAPVVKA KATHIIMNSL ITKQTQESIQ
RFEQQAGLRD AGYTPHKGLT TEETKYLRVA EALHKLKLQS GETTREEKHP ASAQSSPSST
PHSSPKQKSR GWFPSGSSTA LPAPNPHSMD PGGGNDRNSA DKWSLFGPRP LQKSDSGFAI
QAYKGAPKPS PMEVMRAQAT RAGEDPAVFK PPKMDVPVVE GKKQPPRTHN LKPRDLNVLT
PTGF
