P3A2_STRPU
ID P3A2_STRPU Reviewed; 459 AA.
AC Q04073;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=DNA-binding protein P3A2;
OS Strongylocentrotus purpuratus (Purple sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC Strongylocentrotus.
OX NCBI_TaxID=7668;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Embryo;
RX PubMed=1769339; DOI=10.1242/dev.112.1.335;
RA Calzone F.J., Hoog C., Teplow D.B., Cutting A.E., Zeller R.W.,
RA Britten R.J., Davidson E.H.;
RT "Gene regulatory factors of the sea urchin embryo. I. Purification by
RT affinity chromatography and cloning of P3A2, a novel DNA-binding protein.";
RL Development 112:335-350(1991).
RN [2]
RP CHARACTERIZATION.
RX PubMed=1769340; DOI=10.1242/dev.112.1.351;
RA Hoog C., Calzone F.J., Cutting A.E., Britten R.J., Davidson E.H.;
RT "Gene regulatory factors of the sea urchin embryo. II. Two dissimilar
RT proteins, P3A1 and P3A2, bind to the same target sites that are required
RT for early territorial gene expression.";
RL Development 112:351-364(1991).
CC -!- FUNCTION: Transcriptional regulator that interacts with specific sites
CC in the control region of the cyIIIa actin gene. Also binds specifically
CC to similar target sites located in the regulatory region of the SM50
CC gene.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the NRF1/Ewg family. {ECO:0000305}.
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DR EMBL; X57014; CAA40333.1; -; mRNA.
DR PIR; S16434; S16434.
DR RefSeq; NP_999758.1; NM_214593.1.
DR AlphaFoldDB; Q04073; -.
DR STRING; 7668.SPU_017725-tr; -.
DR PRIDE; Q04073; -.
DR EnsemblMetazoa; NM_214593; NP_999758; LOC373404.
DR GeneID; 373404; -.
DR KEGG; spu:373404; -.
DR eggNOG; ENOG502QTK1; Eukaryota.
DR HOGENOM; CLU_018156_3_1_1; -.
DR OrthoDB; 858632at2759; -.
DR Proteomes; UP000007110; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR039142; NRF1/Ewg.
DR InterPro; IPR019526; Nrf1_activation-bd.
DR InterPro; IPR019525; Nrf1_NLS/DNA-bd_dimer.
DR PANTHER; PTHR20338; PTHR20338; 1.
DR Pfam; PF10492; Nrf1_activ_bdg; 1.
DR Pfam; PF10491; Nrf1_DNA-bind; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..459
FT /note="DNA-binding protein P3A2"
FT /id="PRO_0000100212"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 49258 MW; D24E5217A2257427 CRC64;
MMISEDISEP SSPDTPFDDS DLLNSSMTDD VSAQLAASGP IGVRAAAAIA TGKKRKRPHS
FETNPSIRRR QQTRLIRKLK ATIDEYATRV GQQAVVLTCT PGKHDGNFKV FGAAPLENIM
RNLKGIVLQD LDNALAQRAP QPSNENSDLY ELPPLVIDGI PTSVNKMTQA QLRAFIPLML
KYSTGRGKPG WGKESCRPVW WPSDLPWANV RSDVRSEDEK RKVSWTHALV TIVINCYKHH
GRDDLLPEFI EDKCKEIEAS QNQVASLPTA TLLPSHAVVH TINNPDGTVS LIQVDTGATV
ATLADVTQVQ QLTNLQTLQQ VRLQPLQIQH ALGNQQAEAT QAVQTLAEVA AAQGGDGELT
EGQTVTTLPE GTQLVLASDG SLQAINDGTA QGIVIPASVY QTVVAGDGQP IQIANVNIAQ
QSGGGTTMAA IKNAVMQSQP IPSQVATLVV NAASHDQHT