P3F1A_XENLA
ID P3F1A_XENLA Reviewed; 375 AA.
AC P31363; P20915; Q7ZYC6;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2009, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=POU domain, class 3, transcription factor 1-A;
DE AltName: Full=Homeotic protein NRL-22;
DE Short=XlNRL-22;
DE AltName: Full=Transcription factor POU1;
DE Short=XlPOU 1;
DE Short=XlPOU1;
GN Name=pou3f1-a; Synonyms=nrl-22, pou1, pou50;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 7-375, PUTATIVE FUNCTION, TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RC TISSUE=Brain;
RX PubMed=1717323; DOI=10.1016/0012-1606(91)90294-d;
RA Agarwal V.R., Sato S.M.;
RT "XLPOU 1 and XLPOU 2, two novel POU domain genes expressed in the
RT dorsoanterior region of Xenopus embryos.";
RL Dev. Biol. 147:363-373(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 220-324.
RC TISSUE=Neurula;
RX PubMed=2235499; DOI=10.1093/nar/18.20.6131;
RA Baltzinger M., Stiegler P., Remy P.;
RT "Cloning and sequencing of POU-boxes expressed in Xenopus laevis neurula
RT embryos.";
RL Nucleic Acids Res. 18:6131-6131(1990).
CC -!- FUNCTION: Acts as a transcription factor (By similarity). May play a
CC role in neuronal differentiation (PubMed:1717323).
CC {ECO:0000250|UniProtKB:P21952, ECO:0000269|PubMed:1717323}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00530}.
CC -!- TISSUE SPECIFICITY: In embryos at the neural fold stage, localized
CC primarily in the anterior neural plate, and localized mostly in the
CC anterior region of the nerve cord of neurula stage embryos. In tailbud
CC stages, expressed predominantly in the eye and brain, with weak
CC expression along the length of the nerve cord. In adults, expressed in
CC skin and brain. {ECO:0000269|PubMed:1717323}.
CC -!- DEVELOPMENTAL STAGE: Embryonic expression begins at the neural plate
CC stage and continues throughout development to adulthood.
CC {ECO:0000269|PubMed:1717323}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH43847.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA41782.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC043847; AAH43847.1; ALT_INIT; mRNA.
DR EMBL; X59056; CAA41782.1; ALT_INIT; mRNA.
DR EMBL; X54682; CAA38496.1; -; mRNA.
DR PIR; S12183; S12183.
DR PIR; S23248; S23248.
DR RefSeq; NP_001158054.1; NM_001164582.2.
DR AlphaFoldDB; P31363; -.
DR SMR; P31363; -.
DR GeneID; 394338; -.
DR KEGG; xla:394338; -.
DR CTD; 394338; -.
DR Xenbase; XB-GENE-6254450; pou3f1.S.
DR OrthoDB; 752252at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 394338; Expressed in zone of skin and 6 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR InterPro; IPR016362; TF_POU_3.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PIRSF; PIRSF002629; Transcription_factor_POU; 1.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Neurogenesis; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..375
FT /note="POU domain, class 3, transcription factor 1-A"
FT /id="PRO_0000100764"
FT DOMAIN 194..268
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 286..345
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 7..10
FT /note="YLPR -> LLPW (in Ref. 2; CAA41782)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 375 AA; 41846 MW; 55E494F7ECC86EAA CRC64;
MAATAQYLPR NNSLPSNPLM HPDSDRMHQG TTYREVQKMM HQEYLQGLAT NAGHHMSLTP
HQWLPNPASD WGSGSHLGVQ AEHAKSGVQS NREDLSSGFH HHRSHLVHQQ SPSSHAWAQS
GGHHLAPMSP SSNSHQPLIY SQSSYTNLNG MLGPQASSLH HSMRDPLHDD PGVHDTQVDS
PPQHLGHHQD HSDEDAPSSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI
CRFEALQLSF KNMCKLKPLL NKWLEETDST TGSPTNLDKI AAQGRKRKKR TSIEVGVKGA
LENHFLKCPK PSAHEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPAGVP HPPMEDVYSQ
AETPPLHHTL QTSVQ
