P3F2A_XENLA
ID P3F2A_XENLA Reviewed; 382 AA.
AC P31365; B7ZR71; Q8AVS5;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=POU domain, class 3, transcription factor 2-A;
DE AltName: Full=Transcription factor POU3-A;
DE Short=XlPOU3A;
GN Name=pou3f2-a; Synonyms=pou3, pou3a, pou3f2;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Neurula;
RX PubMed=1579504; DOI=10.1093/nar/20.8.1993;
RA Baltzinger M., Payen E., Remy P.;
RT "Nucleotide sequence of XLPOU3 cDNA, a member of the POU domain gene family
RT expressed in Xenopus laevis embryos.";
RL Nucleic Acids Res. 20:1993-1993(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=8887320; DOI=10.1016/s0925-4773(96)00563-1;
RA Baltzinger M., Relaix F., Remy P.;
RT "Transcription of XLPOU3, a brain-specific gene, during Xenopus laevis
RT early embryogenesis.";
RL Mech. Dev. 58:103-114(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula, and Tail bud;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that may be implicated in patterning of
CC the central nervous system during early development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in the developing brain and spinal cord.
CC Also found in a restricted region of the auditory vesicle during
CC development. In the adult, expression is restricted to the brain.
CC {ECO:0000269|PubMed:8887320}.
CC -!- DEVELOPMENTAL STAGE: First expressed at the neurula stage.
CC {ECO:0000269|PubMed:8887320}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH41298.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X64835; CAA46047.1; -; mRNA.
DR EMBL; BC041298; AAH41298.1; ALT_INIT; mRNA.
DR EMBL; BC170064; AAI70064.1; -; mRNA.
DR EMBL; BC170066; AAI70066.1; -; mRNA.
DR PIR; S22652; S22652.
DR RefSeq; NP_001095225.1; NM_001101755.1.
DR AlphaFoldDB; P31365; -.
DR SMR; P31365; -.
DR GeneID; 394422; -.
DR KEGG; xla:394422; -.
DR CTD; 394422; -.
DR Xenbase; XB-GENE-6254215; pou3f2.S.
DR OrthoDB; 752252at2759; -.
DR Proteomes; UP000186698; Chromosome 5S.
DR Bgee; 394422; Expressed in neurula embryo and 7 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR InterPro; IPR016362; TF_POU_3.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PIRSF; PIRSF002629; Transcription_factor_POU; 1.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..382
FT /note="POU domain, class 3, transcription factor 2-A"
FT /id="PRO_0000100725"
FT DOMAIN 201..275
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 293..352
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 69..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 154
FT /note="P -> T (in Ref. 3; AAH41298)"
FT /evidence="ECO:0000305"
FT CONFLICT 341
FT /note="F -> C (in Ref. 1; CAA46047)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 382 AA; 41587 MW; 30197A0BCAF74881 CRC64;
MATTASNHYN LLGSGSSIVH ADPGGMQQAQ SYRDAQTLVQ SDYTLQSNGH PLSHAHQWIT
ALSHGDGAPW ATSPLGQQDI KPTVQSSRDE LHVSGTLQHQ SRAPHLVHPA HGNHHGPGAW
RSTGSTHLSS MASSNGQGLL YSQPSFTVNG MINPGSGQGI HHHGLRDSHD DHHGDHGHQQ
VSQAQQQHSQ LQGGHQDHSD EDTPTSDDLE QFAKQFKQRR IKLGFTQADV GLALGTLYGN
VFSQTTICRF EALQLSFKNM CKLKPLLNKW LEEADSSSGS PTSIDKIAAQ GRKRKKRTSI
EVSVKGALES HFLKCPKPSA PEITSLADSL QLEKEVVRVW FCNRRQKEKR MTPPGGTIPG
AEDIYGASRD TPPHLGVQTS VQ
