ID   P3F2B_XENLA             Reviewed;         385 AA.
AC   P70030; B1H1P3; Q6IP58;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=POU domain, class 3, transcription factor 2-B;
DE   AltName: Full=Transcription factor POU3-B;
DE            Short=XlPOU3B;
GN   Name=pou3f2-b; Synonyms=pou3b, pou3f2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=8887320; DOI=10.1016/s0925-4773(96)00563-1;
RA   Baltzinger M., Relaix F., Remy P.;
RT   "Transcription of XLPOU3, a brain-specific gene, during Xenopus laevis
RT   early embryogenesis.";
RL   Mech. Dev. 58:103-114(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula, and Tail bud;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that may be implicated in patterning of
CC       the central nervous system during early development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed in the developing brain and spinal cord.
CC       Also found in a restricted region of the auditory vesicle during
CC       development. In the adult, expression is restricted to the brain.
CC       {ECO:0000269|PubMed:8887320}.
CC   -!- DEVELOPMENTAL STAGE: First expressed at the neurula stage.
CC       {ECO:0000269|PubMed:8887320}.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; X96423; CAA65283.1; -; Genomic_DNA.
DR   EMBL; BC072060; AAH72060.1; -; mRNA.
DR   EMBL; BC160684; AAI60684.1; -; mRNA.
DR   RefSeq; NP_001090220.1; NM_001096751.1.
DR   AlphaFoldDB; P70030; -.
DR   SMR; P70030; -.
DR   DNASU; 779122; -.
DR   GeneID; 779122; -.
DR   KEGG; xla:779122; -.
DR   CTD; 779122; -.
DR   Xenbase; XB-GENE-483178; pou3f2.L.
DR   OMA; QHHGGEH; -.
DR   OrthoDB; 752252at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 779122; Expressed in brain and 7 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0007420; P:brain development; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_dom.
DR   InterPro; IPR016362; TF_POU_3.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PIRSF; PIRSF002629; Transcription_factor_POU; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..385
FT                   /note="POU domain, class 3, transcription factor 2-B"
FT                   /id="PRO_0000100726"
FT   DOMAIN          204..278
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT   DNA_BIND        296..355
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          106..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..136
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..195
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   385 AA;  41985 MW;  59001F5CCC0B2F3D CRC64;
     MATTASNHYN LLGSGSSIVH ADPGGMQQAQ SYRDAQTLVQ SDYTLQSNGH PLSHAHQWIT
     ALSHGDGAPW ATSPLGQQDI KPTVQSSRDE LHGSGTLQHQ SRAPHLVHPA HGNHHGPGAW
     RSTGSTHLSS MASSNGQGLL YSQPSFTVNG MINPGSGQGM HHHGLRDSHD DHHGDHGHQQ
     PSQTQQQQQQ HSQLQGGHHD HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL
     YGNVFSQTTI CRFEALQLSF KNMCKLKPLL NKWLEEADSS SGSPTSIDKI AAQGRKRKKR
     TSIEVSVKGA LESHFLKCPK PAAQEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPPGGT
     IPGAEDVYGA SRDTPPHLGV QTSVQ