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P3F4A_XENLA
ID   P3F4A_XENLA             Reviewed;         361 AA.
AC   P31364; Q6DFJ0;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=POU domain, class 3, transcription factor 4-A;
DE   AltName: Full=Transcription factor POU2;
DE            Short=XlPOU 2;
DE            Short=XlPOU2;
GN   Name=pou3f4-a; Synonyms=pou2, pou3f4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP   STAGE, AND INDUCTION.
RC   TISSUE=Brain;
RX   PubMed=7720579; DOI=10.1242/dev.121.3.721;
RA   Witta S.E., Agarwal V.R., Sato S.M.;
RT   "XLPOU 2, a noggin-inducible gene, has direct neuralizing activity.";
RL   Development 121:721-730(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 127-361, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   TISSUE=Brain;
RX   PubMed=1717323; DOI=10.1016/0012-1606(91)90294-d;
RA   Agarwal V.R., Sato S.M.;
RT   "XLPOU 1 and XLPOU 2, two novel POU domain genes expressed in the
RT   dorsoanterior region of Xenopus embryos.";
RL   Dev. Biol. 147:363-373(1991).
RN   [4]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=10559482; DOI=10.1016/s0925-4773(99)00204-x;
RA   Matsuo-Takasaki M., Lim J.H., Sato S.M.;
RT   "The POU domain gene, XlPOU 2 is an essential downstream determinant of
RT   neural induction.";
RL   Mech. Dev. 89:75-85(1999).
CC   -!- FUNCTION: Transcriptional activator. Induces neural-specific gene
CC       expression to act as a key regulator of neural differentiation.
CC       {ECO:0000269|PubMed:10559482, ECO:0000269|PubMed:7720579}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: From embryonic stage 10, expressed in the Spemann's
CC       organizer. During gastrulation, expressed in both the involuting
CC       mesoderm and the overlying neuroectoderm. During the neural plate and
CC       neural fold stages, expressed in the entire neuroectoderm with
CC       expression in discrete regions of the developing nervous system
CC       persisting at later stages. Transiently expressed in the pronephros
CC       from stages 24-32. In adults, expressed in the kidney and brain.
CC       {ECO:0000269|PubMed:1717323, ECO:0000269|PubMed:7720579}.
CC   -!- DEVELOPMENTAL STAGE: First expressed at embryonic stage 9, with
CC       expression increasing at neurula stage and again at the tailbud stage.
CC       Expression persists through development to adulthood.
CC       {ECO:0000269|PubMed:1717323, ECO:0000269|PubMed:7720579}.
CC   -!- INDUCTION: By nog, zic1 and zic3. {ECO:0000269|PubMed:10559482,
CC       ECO:0000269|PubMed:7720579}.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA41781.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U17654; AAA92684.1; -; mRNA.
DR   EMBL; BC076747; AAH76747.1; -; mRNA.
DR   EMBL; X59055; CAA41781.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001094393.1; NM_001100923.1.
DR   AlphaFoldDB; P31364; -.
DR   SMR; P31364; -.
DR   DNASU; 397929; -.
DR   GeneID; 397929; -.
DR   KEGG; xla:397929; -.
DR   CTD; 397929; -.
DR   Xenbase; XB-GENE-865294; pou3f4.L.
DR   OMA; HNNHGSH; -.
DR   OrthoDB; 752252at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 397929; Expressed in internal ear and 5 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0007420; P:brain development; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_dom.
DR   InterPro; IPR016362; TF_POU_3.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PIRSF; PIRSF002629; Transcription_factor_POU; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..361
FT                   /note="POU domain, class 3, transcription factor 4-A"
FT                   /id="PRO_0000100765"
FT   DOMAIN          186..260
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT   DNA_BIND        278..337
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          100..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..189
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        347..361
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        127
FT                   /note="S -> G (in Ref. 3; CAA41781)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   361 AA;  39838 MW;  6F6BE1D6AC844F81 CRC64;
     MATAASNPYS ILSSSSLVHA DSAVMQQGSP FRNPQKLLQS DYLQGVPCNG HPLGHHWVTS
     LSDANPWSSS LASSPLDQQD IKPGREDLQL GAIIHHRSPH VNHHSPHTNH PNAWGASPAH
     NSSLTSSGQP INIYSQPSFT VSGMLDHGEL TPPLPAGTTQ SLHPVLREPN DHVDLGSHHC
     QDHSDEETPT SDELEQFAKQ FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL
     SFKNMCKLKP LLNKWLEEAD SSTGNPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC
     PKPAALEITS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DPQQHEVYSH SVKTDTSCNE
     L
 
 
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