ID   P3F4B_XENLA             Reviewed;         356 AA.
AC   Q6DJN3;
DT   15-DEC-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=POU domain, class 3, transcription factor 4-B;
GN   Name=pou3f4-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH75142.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000312|EMBL:AAH75142.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator. Induces neural-specific gene
CC       expression to act as a key regulator of neural differentiation (By
CC       similarity). {ECO:0000250|UniProtKB:P31364}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P49335,
CC       ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-
CC       ProRule:PRU00530}.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3
CC       subfamily. {ECO:0000255}.
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DR   EMBL; BC075142; AAH75142.1; -; mRNA.
DR   RefSeq; NP_001086347.1; NM_001092878.1.
DR   AlphaFoldDB; Q6DJN3; -.
DR   SMR; Q6DJN3; -.
DR   GeneID; 444776; -.
DR   KEGG; xla:444776; -.
DR   CTD; 444776; -.
DR   OrthoDB; 752252at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 444776; Expressed in internal ear and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0007420; P:brain development; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_dom.
DR   InterPro; IPR016362; TF_POU_3.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PIRSF; PIRSF002629; Transcription_factor_POU; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..356
FT                   /note="POU domain, class 3, transcription factor 4-B"
FT                   /id="PRO_0000389616"
FT   DOMAIN          181..255
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT   DNA_BIND        273..332
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          97..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          328..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..187
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..356
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   356 AA;  39174 MW;  9D32C537C04980B7 CRC64;
     MATAASNPYS ILSSSSLVHA DSAVMQQGSP FRNPQKLLQS DYLQGIPSNG HPLGHHWVTS
     LSDANPWSSL ASSPLDQQDI KPGREDLQLG AIIHHRSPHV SHHSPHNNHP NTWGASPVHN
     SSGQPINVYS QPGFTVSGML DHGGLTPPPP SGTTQSLHPV LREATDHGDL GSHHCHDHSD
     EETPTSDELE QFAKLFKQRR IKLGFTQADV GLALGTLYGN VFSQTTICRF EALQLSFKNM
     CKLKPLLNKW LEEADSSTGS PTSIDKIAAQ GRKRKKRTSI EVSVKGVLET HFLKCPKPAA
     LEISSLADSL QLEKEVVRVW FCNRRQKEKR MTPPGDPQQH EIYSHSVKTD TSCNEL