ID   P3IP1_DANRE             Reviewed;         263 AA.
AC   Q7SXB3;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Phosphoinositide-3-kinase-interacting protein 1;
DE   AltName: Full=Kringle domain-containing protein HGFL;
DE   Flags: Precursor;
GN   Name=pik3ip1; Synonyms=hgfl; ORFNames=zgc:66482;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of hepatic phosphatidylinositol 3-kinase
CC       (PI3K) activity. {ECO:0000250|UniProtKB:Q7TMJ8}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96FE7};
CC       Single-pass type I membrane protein {ECO:0000255}.
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DR   EMBL; BC055675; AAH55675.1; -; mRNA.
DR   EMBL; BC067191; AAH67191.1; -; mRNA.
DR   RefSeq; NP_938188.1; NM_198374.1.
DR   AlphaFoldDB; Q7SXB3; -.
DR   SMR; Q7SXB3; -.
DR   STRING; 7955.ENSDARP00000115818; -.
DR   PaxDb; Q7SXB3; -.
DR   GeneID; 386643; -.
DR   KEGG; dre:386643; -.
DR   CTD; 113791; -.
DR   ZFIN; ZDB-GENE-031030-14; pik3ip1.
DR   eggNOG; ENOG502QTWD; Eukaryota.
DR   InParanoid; Q7SXB3; -.
DR   OrthoDB; 1027586at2759; -.
DR   PhylomeDB; Q7SXB3; -.
DR   PRO; PR:Q7SXB3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0036313; F:phosphatidylinositol 3-kinase catalytic subunit binding; IBA:GO_Central.
DR   GO; GO:0043553; P:negative regulation of phosphatidylinositol 3-kinase activity; ISS:UniProtKB.
DR   GO; GO:0014067; P:negative regulation of phosphatidylinositol 3-kinase signaling; IBA:GO_Central.
DR   CDD; cd00108; KR; 1.
DR   Gene3D; 2.40.20.10; -; 1.
DR   InterPro; IPR000001; Kringle.
DR   InterPro; IPR013806; Kringle-like.
DR   InterPro; IPR018056; Kringle_CS.
DR   InterPro; IPR038178; Kringle_sf.
DR   Pfam; PF00051; Kringle; 1.
DR   SMART; SM00130; KR; 1.
DR   SUPFAM; SSF57440; SSF57440; 1.
DR   PROSITE; PS00021; KRINGLE_1; 1.
DR   PROSITE; PS50070; KRINGLE_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Kringle; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..263
FT                   /note="Phosphoinositide-3-kinase-interacting protein 1"
FT                   /id="PRO_0000280351"
FT   TOPO_DOM        19..163
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        185..263
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          24..99
FT                   /note="Kringle"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
FT   REGION          239..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        103
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        25..99
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
FT   DISULFID        46..80
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
FT   DISULFID        69..94
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
SQ   SEQUENCE   263 AA;  28777 MW;  8BEBC117EC7C8A58 CRC64;
     MFGRLYFMLL LSVGLVDCLS VVKDCITNNG EDYRGTQQKT SSGSTCLSWR SLNLKFKDSQ
     TGVGDHNFCR NPDGSNKPWC YVSGSSGETK KEACDIRICQ DQNATEAPAP EESVPTQGLT
     QRMVETFEPA NSFPSQVEGA AVQPVKGVRQ QVRSGPKKKK DLGTLGYVLA VFMMAIIILL
     GGGITMGYFY KRGRDLKKQH EQRVYEREMH RITLPLSAFA NPTCELVDEN TIVITAEPNN
     QTPTQEPVEG ADPLMGSAGT PGA